4TMAA

Crystal structure of gyrase bound to its inhibitor yacg
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
508
structure length
505
Chain Sequence
LKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLNVAAMLERAGDDAARPEWLEPEFGVDGLYYLEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein.
pubmed doi rcsb
molecule tags Isomerase/isomerase inhibitor
source organism Escherichia coli
molecule keywords DNA gyrase subunit A
total genus 136
structure length 505
sequence length 508
chains with identical sequence C, E, G
ec nomenclature ec 5.99.1.3: Transferred entry: 5.6.2.3.
pdb deposition date 2014-05-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.268.10 Mainly Alpha Orthogonal Bundle Topoisomerase; domain 3 Topoisomerase, domain 3 4tmaA03
3.90.199.10 Alpha Beta Alpha-Beta Complex Topoisomerase II; domain 5 Topoisomerase II, domain 5 4tmaA01
3QX3A 1BJTA 1X75A 4CKLA 2XCRB 4Z53A 4G0VA 3FOFA 2XCOA 3NUHA 2Y3PA 4ELYA 4G0WA 3LPXA 4TMAA 4CKKA 1AB4A 4Z3OA 2RGRA 4G0UA 1BGWA 3L4KA 1ZVUA 4J3NA 4DDQA 4ELZA 3L4JA 4FM9A 2XCQA 3FOEA 4Z4QA
chains in the Genus database with same CATH superfamily
3QX3A 1BJTA 1X75A 4CKLA 2XCRB 4Z53A 4G0VA 4CIDA 2XCOA 3FOFA 3NUHA 2Y3PA 4ELYA 4G0WA 2QPTA 3LPXA 4TMAA 4CKKA 1AB4A 4Z3OA 2RGRA 4G0UA 1BGWA 3L4KA 1ZVUA 4J3NA 4DDQA 4ELZA 3L4JA 4FM9A 2XCQA 3FOEA 4Z4QA
chains in the Genus database with same CATH topology
3QX3A 1BJTA 1X75A 4CKLA 2XCRB 4Z53A 4G0VA 3FOFA 2XCOA 3NUHA 2Y3PA 4ELYA 4G0WA 3LPXA 4TMAA 4CKKA 1AB4A 4Z3OA 2RGRA 4G0UA 1BGWA 3L4KA 1ZVUA 4J3NA 4DDQA 4ELZA 3L4JA 4FM9A 2XCQA 3FOEA 4Z4QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QX3 A;  1BJT A;  1X75 A;  4CKL A;  2XCR B;  4Z53 A;  4G0V A;  3FOF A;  2XCO A;  3NUH A;  2Y3P A;  4ELY A;  4G0W A;  3LPX A;  4TMA A;  4CKK A;  1AB4 A;  4Z3O A;  2RGR A;  4G0U A;  1BGW A;  3L4K A;  1ZVU A;  4J3N A;  4DDQ A;  4ELZ A;  3L4J A;  4FM9 A;  2XCQ A;  3FOE A;  4Z4Q A; 
#chains in the Genus database with same CATH topology
 3QX3 A;  1BJT A;  1X75 A;  4CKL A;  2XCR B;  4Z53 A;  4G0V A;  4CID A;  2XCO A;  3FOF A;  3NUH A;  2Y3P A;  4ELY A;  4G0W A;  2QPT A;  3LPX A;  4TMA A;  4CKK A;  1AB4 A;  4Z3O A;  2RGR A;  4G0U A;  1BGW A;  3L4K A;  1ZVU A;  4J3N A;  4DDQ A;  4ELZ A;  3L4J A;  4FM9 A;  2XCQ A;  3FOE A;  4Z4Q A; 
#chains in the Genus database with same CATH homology
 3QX3 A;  1BJT A;  1X75 A;  4CKL A;  2XCR B;  4Z53 A;  4G0V A;  3FOF A;  2XCO A;  3NUH A;  2Y3P A;  4ELY A;  4G0W A;  3LPX A;  4TMA A;  4CKK A;  1AB4 A;  4Z3O A;  2RGR A;  4G0U A;  1BGW A;  3L4K A;  1ZVU A;  4J3N A;  4DDQ A;  4ELZ A;  3L4J A;  4FM9 A;  2XCQ A;  3FOE A;  4Z4Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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