4U6VA

Mechanisms of neutralization of a human anti-alpha toxin antibody
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
282
structure length
272
Chain Sequence
TDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWIDRSSERYKIDWEKEEMTN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
molecule keywords Fab, antigen binding fragment, heavy chain
publication title Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
pubmed doi rcsb
source organism Homo sapiens
total genus 68
structure length 272
sequence length 282
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4u6vA00
3M2LA 4YHDA 3O44A 4I0NA 2QK7B 1LKFA 4P1YB 2LKFA 4IZLA 4Q7GA 4P1XA 4IYAA 2QK7A 4P1YA 1PVLA 3B07B 4TW1B 1T5RA 3ROHA 4U6VA 3B07A 3ANZA 4IDJA 4IYTA 3M4EA 4TW1A 3LKFA 4J0OA 5K59A 4P24A 4H56A 3M4DA 5K59C 7AHLA 2YGTA 3M3RA 4P1XB 4IYCA
chains in the Genus database with same CATH superfamily
3M2LA 4YHDA 3O44A 4I0NA 2QK7B 1LKFA 4P1YB 2LKFA 4IZLA 4Q7GA 4P1XA 4IYAA 1XEZA 2QK7A 4P1YA 1PVLA 3B07B 4TW1B 1T5RA 3ROHA 4U6VA 3B07A 3ANZA 4IDJA 4IYTA 3M4EA 4TW1A 3LKFA 4J0OA 5K59A 4P24A 4H56A 3M4DA 5K59C 7AHLA 2YGTA 3M3RA 4P1XB 4IYCA
chains in the Genus database with same CATH topology
3M2LA 4YHDA 3O44A 4I0NA 2QK7B 1LKFA 4P1YB 2LKFA 4IZLA 4Q7GA 4P1XA 4IYAA 2QK7A 4P1YA 1PVLA 3B07B 4TW1B 1T5RA 3ROHA 4U6VA 3B07A 3ANZA 4IDJA 4IYTA 3M4EA 4TW1A 3LKFA 4J0OA 5K59A 4P24A 4H56A 3M4DA 5K59C 7AHLA 2YGTA 3M3RA 4P1XB 4IYCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M2L A;  4YHD A;  3O44 A;  4I0N A;  2QK7 B;  1LKF A;  4P1Y B;  2LKF A;  4IZL A;  4Q7G A;  4P1X A;  4IYA A;  2QK7 A;  4P1Y A;  1PVL A;  3B07 B;  4TW1 B;  1T5R A;  3ROH A;  4U6V A;  3B07 A;  3ANZ A;  4IDJ A;  4IYT A;  3M4E A;  4TW1 A;  3LKF A;  4J0O A;  5K59 A;  4P24 A;  4H56 A;  3M4D A;  5K59 C;  7AHL A;  2YGT A;  3M3R A;  4P1X B;  4IYC A; 
#chains in the Genus database with same CATH topology
 3M2L A;  4YHD A;  3O44 A;  4I0N A;  2QK7 B;  1LKF A;  4P1Y B;  2LKF A;  4IZL A;  4Q7G A;  4P1X A;  4IYA A;  1XEZ A;  2QK7 A;  4P1Y A;  1PVL A;  3B07 B;  4TW1 B;  1T5R A;  3ROH A;  4U6V A;  3B07 A;  3ANZ A;  4IDJ A;  4IYT A;  3M4E A;  4TW1 A;  3LKF A;  4J0O A;  5K59 A;  4P24 A;  4H56 A;  3M4D A;  5K59 C;  7AHL A;  2YGT A;  3M3R A;  4P1X B;  4IYC A; 
#chains in the Genus database with same CATH homology
 3M2L A;  4YHD A;  3O44 A;  4I0N A;  2QK7 B;  1LKF A;  4P1Y B;  2LKF A;  4IZL A;  4Q7G A;  4P1X A;  4IYA A;  2QK7 A;  4P1Y A;  1PVL A;  3B07 B;  4TW1 B;  1T5R A;  3ROH A;  4U6V A;  3B07 A;  3ANZ A;  4IDJ A;  4IYT A;  3M4E A;  4TW1 A;  3LKF A;  4J0O A;  5K59 A;  4P24 A;  4H56 A;  3M4D A;  5K59 C;  7AHL A;  2YGT A;  3M3R A;  4P1X B;  4IYC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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