1KLQA

The mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either mad1 or cdc20
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
197
structure length
197
Chain Sequence
GSITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
total genus 40
structure length 197
sequence length 197
ec nomenclature
pdb deposition date 2001-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 1klqA00
4GK0A 4TZOA 1DUJA 4TZLA 2VFXA 4TRKA 2V64D 4YK8B 3ABDA 4J2GA 4AEZB 1KLQA 4EXTC 3GMHA 4TZNA 4TZJA 4TZQA 2QYFA 5C50B 2V64A 4FJOC 4TZSA 4TZMA 3ABEC 5LCWZ 1S2HA 4GK5A 3VU7C 1GO4A
chains in the Genus database with same CATH superfamily
2QYFB 4GK0A 4TZOA 1DUJA 4TZLA 2VFXA 4TRKA 2V64D 4YK8B 3ABDA 4J2GA 4AEZB 1KLQA 4EXTC 3GMHA 4TZNA 4TZJA 4TZQA 2QYFA 5C50B 2V64A 4FJOC 4TZSA 4TZMA 3ABEC 5LCWZ 1S2HA 4GK5A 3VU7C 1GO4A
chains in the Genus database with same CATH topology
4GK0A 4TZOA 1DUJA 4TZLA 2VFXA 4TRKA 2V64D 4YK8B 3ABDA 4J2GA 4AEZB 1KLQA 4EXTC 3GMHA 4TZNA 4TZJA 4TZQA 2QYFA 5C50B 2V64A 4FJOC 4TZSA 4TZMA 3ABEC 5LCWZ 1S2HA 4GK5A 3VU7C 1GO4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GK0 A;  4TZO A;  1DUJ A;  4TZL A;  2VFX A;  4TRK A;  2V64 D;  4YK8 B;  3ABD A;  4J2G A;  4AEZ B;  1KLQ A;  4EXT C;  3GMH A;  4TZN A;  4TZJ A;  4TZQ A;  2QYF A;  5C50 B;  2V64 A;  4FJO C;  4TZS A;  4TZM A;  3ABE C;  5LCW Z;  1S2H A;  4GK5 A;  3VU7 C;  1GO4 A; 
#chains in the Genus database with same CATH topology
 2QYF B;  4GK0 A;  4TZO A;  1DUJ A;  4TZL A;  2VFX A;  4TRK A;  2V64 D;  4YK8 B;  3ABD A;  4J2G A;  4AEZ B;  1KLQ A;  4EXT C;  3GMH A;  4TZN A;  4TZJ A;  4TZQ A;  2QYF A;  5C50 B;  2V64 A;  4FJO C;  4TZS A;  4TZM A;  3ABE C;  5LCW Z;  1S2H A;  4GK5 A;  3VU7 C;  1GO4 A; 
#chains in the Genus database with same CATH homology
 4GK0 A;  4TZO A;  1DUJ A;  4TZL A;  2VFX A;  4TRK A;  2V64 D;  4YK8 B;  3ABD A;  4J2G A;  4AEZ B;  1KLQ A;  4EXT C;  3GMH A;  4TZN A;  4TZJ A;  4TZQ A;  2QYF A;  5C50 B;  2V64 A;  4FJO C;  4TZS A;  4TZM A;  3ABE C;  5LCW Z;  1S2H A;  4GK5 A;  3VU7 C;  1GO4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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