1KLQA

The mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either mad1 or cdc20
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
197
structure length
197
Chain Sequence
GSITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
total genus 40
structure length 197
sequence length 197
ec nomenclature
pdb deposition date 2001-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 1klqA00
4TZSA 3GMHA 2VFXA 1S2HA 4GK0A 2V64D 4FJOC 4AEZB 4TZJA 1KLQA 4TRKA 2V64A 4TZNA 1GO4A 5C50B 4TZLA 3VU7C 1DUJA 4EXTC 4J2GA 4TZMA 4YK8B 5LCWZ 4TZOA 3ABEC 2QYFA 4GK5A 4TZQA 3ABDA
chains in the Genus database with same CATH superfamily
4TZSA 3GMHA 2VFXA 1S2HA 4GK0A 2V64D 4FJOC 4AEZB 2QYFB 4TZJA 1KLQA 4TRKA 2V64A 4TZNA 1GO4A 5C50B 4TZLA 3VU7C 1DUJA 4EXTC 4J2GA 4TZMA 4YK8B 5LCWZ 4TZOA 3ABEC 2QYFA 4GK5A 4TZQA 3ABDA
chains in the Genus database with same CATH topology
4TZSA 3GMHA 2VFXA 1S2HA 4GK0A 2V64D 4FJOC 4AEZB 4TZJA 1KLQA 4TRKA 2V64A 4TZNA 1GO4A 5C50B 4TZLA 3VU7C 1DUJA 4EXTC 4J2GA 4TZMA 4YK8B 5LCWZ 4TZOA 3ABEC 2QYFA 4GK5A 4TZQA 3ABDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZS A;  3GMH A;  2VFX A;  1S2H A;  4GK0 A;  2V64 D;  4FJO C;  4AEZ B;  4TZJ A;  1KLQ A;  4TRK A;  2V64 A;  4TZN A;  1GO4 A;  5C50 B;  4TZL A;  3VU7 C;  1DUJ A;  4EXT C;  4J2G A;  4TZM A;  4YK8 B;  5LCW Z;  4TZO A;  3ABE C;  2QYF A;  4GK5 A;  4TZQ A;  3ABD A; 
#chains in the Genus database with same CATH topology
 4TZS A;  3GMH A;  2VFX A;  1S2H A;  4GK0 A;  2V64 D;  4FJO C;  4AEZ B;  2QYF B;  4TZJ A;  1KLQ A;  4TRK A;  2V64 A;  4TZN A;  1GO4 A;  5C50 B;  4TZL A;  3VU7 C;  1DUJ A;  4EXT C;  4J2G A;  4TZM A;  4YK8 B;  5LCW Z;  4TZO A;  3ABE C;  2QYF A;  4GK5 A;  4TZQ A;  3ABD A; 
#chains in the Genus database with same CATH homology
 4TZS A;  3GMH A;  2VFX A;  1S2H A;  4GK0 A;  2V64 D;  4FJO C;  4AEZ B;  4TZJ A;  1KLQ A;  4TRK A;  2V64 A;  4TZN A;  1GO4 A;  5C50 B;  4TZL A;  3VU7 C;  1DUJ A;  4EXT C;  4J2G A;  4TZM A;  4YK8 B;  5LCW Z;  4TZO A;  3ABE C;  2QYF A;  4GK5 A;  4TZQ A;  3ABD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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