1S2HA

The mad2 spindle checkpoint protein possesses two distinct natively folded states
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
205
structure length
205
Chain Sequence
MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIAQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Mad2 spindle checkpoint protein has two distinct natively folded states.
pubmed doi rcsb
molecule keywords Mitotic spindle assembly checkpoint protein MAD2A
molecule tags Cell cycle
source organism Homo sapiens
total genus 38
structure length 205
sequence length 205
ec nomenclature
pdb deposition date 2004-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 1s2hA00
3VU7C 2V64A 4TZMA 4GK0A 1GO4A 5LCWZ 4AEZB 2QYFA 4YK8B 1S2HA 4TZLA 4TZSA 4EXTC 2V64D 3ABEC 3ABDA 4TRKA 3GMHA 4TZNA 4TZJA 2VFXA 1KLQA 4GK5A 1DUJA 4FJOC 4J2GA 4TZQA 5C50B 4TZOA
chains in the Genus database with same CATH superfamily
3VU7C 2V64A 4TZMA 4GK0A 1GO4A 5LCWZ 4AEZB 2QYFA 4YK8B 1S2HA 4TZLA 4TZSA 4EXTC 2V64D 3ABEC 2QYFB 3ABDA 4TRKA 3GMHA 4TZNA 4TZJA 2VFXA 1KLQA 4GK5A 1DUJA 4FJOC 4J2GA 4TZQA 5C50B 4TZOA
chains in the Genus database with same CATH topology
3VU7C 2V64A 4TZMA 4GK0A 1GO4A 5LCWZ 4AEZB 2QYFA 4YK8B 1S2HA 4TZLA 4TZSA 4EXTC 2V64D 3ABEC 3ABDA 4TRKA 3GMHA 4TZNA 4TZJA 2VFXA 1KLQA 4GK5A 1DUJA 4FJOC 4J2GA 4TZQA 5C50B 4TZOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VU7 C;  2V64 A;  4TZM A;  4GK0 A;  1GO4 A;  5LCW Z;  4AEZ B;  2QYF A;  4YK8 B;  1S2H A;  4TZL A;  4TZS A;  4EXT C;  2V64 D;  3ABE C;  3ABD A;  4TRK A;  3GMH A;  4TZN A;  4TZJ A;  2VFX A;  1KLQ A;  4GK5 A;  1DUJ A;  4FJO C;  4J2G A;  4TZQ A;  5C50 B;  4TZO A; 
#chains in the Genus database with same CATH topology
 3VU7 C;  2V64 A;  4TZM A;  4GK0 A;  1GO4 A;  5LCW Z;  4AEZ B;  2QYF A;  4YK8 B;  1S2H A;  4TZL A;  4TZS A;  4EXT C;  2V64 D;  3ABE C;  2QYF B;  3ABD A;  4TRK A;  3GMH A;  4TZN A;  4TZJ A;  2VFX A;  1KLQ A;  4GK5 A;  1DUJ A;  4FJO C;  4J2G A;  4TZQ A;  5C50 B;  4TZO A; 
#chains in the Genus database with same CATH homology
 3VU7 C;  2V64 A;  4TZM A;  4GK0 A;  1GO4 A;  5LCW Z;  4AEZ B;  2QYF A;  4YK8 B;  1S2H A;  4TZL A;  4TZS A;  4EXT C;  2V64 D;  3ABE C;  3ABD A;  4TRK A;  3GMH A;  4TZN A;  4TZJ A;  2VFX A;  1KLQ A;  4GK5 A;  1DUJ A;  4FJO C;  4J2G A;  4TZQ A;  5C50 B;  4TZO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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