1S2HA

The mad2 spindle checkpoint protein possesses two distinct natively folded states
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
205
structure length
205
Chain Sequence
MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIAQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Mad2 spindle checkpoint protein has two distinct natively folded states.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords Mitotic spindle assembly checkpoint protein MAD2A
total genus 38
structure length 205
sequence length 205
ec nomenclature
pdb deposition date 2004-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 1s2hA00
4J2GA 4TZJA 4AEZB 1DUJA 4TRKA 4FJOC 5LCWZ 4EXTC 4TZSA 2V64A 4TZLA 2QYFA 4YK8B 4GK5A 3GMHA 1GO4A 4TZMA 4TZOA 4TZQA 1S2HA 5C50B 4TZNA 3VU7C 2V64D 2VFXA 4GK0A 3ABEC 3ABDA 1KLQA
chains in the Genus database with same CATH superfamily
4J2GA 4TZJA 4AEZB 1DUJA 4TRKA 4FJOC 5LCWZ 4EXTC 4TZSA 2QYFB 2V64A 4TZLA 2QYFA 4YK8B 4GK5A 3GMHA 1GO4A 4TZMA 4TZOA 4TZQA 1S2HA 5C50B 4TZNA 3VU7C 2V64D 2VFXA 4GK0A 3ABEC 3ABDA 1KLQA
chains in the Genus database with same CATH topology
4J2GA 4TZJA 4AEZB 1DUJA 4TRKA 4FJOC 5LCWZ 4EXTC 4TZSA 2V64A 4TZLA 2QYFA 4YK8B 4GK5A 3GMHA 1GO4A 4TZMA 4TZOA 4TZQA 1S2HA 5C50B 4TZNA 3VU7C 2V64D 2VFXA 4GK0A 3ABEC 3ABDA 1KLQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J2G A;  4TZJ A;  4AEZ B;  1DUJ A;  4TRK A;  4FJO C;  5LCW Z;  4EXT C;  4TZS A;  2V64 A;  4TZL A;  2QYF A;  4YK8 B;  4GK5 A;  3GMH A;  1GO4 A;  4TZM A;  4TZO A;  4TZQ A;  1S2H A;  5C50 B;  4TZN A;  3VU7 C;  2V64 D;  2VFX A;  4GK0 A;  3ABE C;  3ABD A;  1KLQ A; 
#chains in the Genus database with same CATH topology
 4J2G A;  4TZJ A;  4AEZ B;  1DUJ A;  4TRK A;  4FJO C;  5LCW Z;  4EXT C;  4TZS A;  2QYF B;  2V64 A;  4TZL A;  2QYF A;  4YK8 B;  4GK5 A;  3GMH A;  1GO4 A;  4TZM A;  4TZO A;  4TZQ A;  1S2H A;  5C50 B;  4TZN A;  3VU7 C;  2V64 D;  2VFX A;  4GK0 A;  3ABE C;  3ABD A;  1KLQ A; 
#chains in the Genus database with same CATH homology
 4J2G A;  4TZJ A;  4AEZ B;  1DUJ A;  4TRK A;  4FJO C;  5LCW Z;  4EXT C;  4TZS A;  2V64 A;  4TZL A;  2QYF A;  4YK8 B;  4GK5 A;  3GMH A;  1GO4 A;  4TZM A;  4TZO A;  4TZQ A;  1S2H A;  5C50 B;  4TZN A;  3VU7 C;  2V64 D;  2VFX A;  4GK0 A;  3ABE C;  3ABD A;  1KLQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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