2V64D

Crystallographic structure of the conformational dimer of the spindle assembly checkpoint protein mad2.
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
181
structure length
171
Chain Sequence
EQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKGSGEKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLPQFITNSEEVRLRSFTTTIHKVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The MAD2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
total genus 55
structure length 171
sequence length 181
chains with identical sequence E, H
ec nomenclature
pdb deposition date 2007-07-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 2v64D00
4AEZB 2VFXA 4TRKA 3GMHA 4TZLA 2QYFA 4GK0A 3VU7C 5LCWZ 4FJOC 4YK8B 4TZSA 4TZJA 2V64A 1DUJA 1KLQA 2V64D 4TZOA 3ABEC 4TZQA 4J2GA 4TZMA 1S2HA 3ABDA 5C50B 4EXTC 1GO4A 4GK5A 4TZNA
chains in the Genus database with same CATH superfamily
4AEZB 2VFXA 4TRKA 3GMHA 4TZLA 2QYFA 4GK0A 2QYFB 3VU7C 5LCWZ 4FJOC 4YK8B 4TZSA 4TZJA 2V64A 1DUJA 1KLQA 2V64D 4TZOA 3ABEC 4TZQA 4J2GA 4TZMA 1S2HA 3ABDA 5C50B 4EXTC 1GO4A 4GK5A 4TZNA
chains in the Genus database with same CATH topology
4AEZB 2VFXA 4TRKA 3GMHA 4TZLA 2QYFA 4GK0A 3VU7C 5LCWZ 4FJOC 4YK8B 4TZSA 4TZJA 2V64A 1DUJA 1KLQA 2V64D 4TZOA 3ABEC 4TZQA 4J2GA 4TZMA 1S2HA 3ABDA 5C50B 4EXTC 1GO4A 4GK5A 4TZNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AEZ B;  2VFX A;  4TRK A;  3GMH A;  4TZL A;  2QYF A;  4GK0 A;  3VU7 C;  5LCW Z;  4FJO C;  4YK8 B;  4TZS A;  4TZJ A;  2V64 A;  1DUJ A;  1KLQ A;  2V64 D;  4TZO A;  3ABE C;  4TZQ A;  4J2G A;  4TZM A;  1S2H A;  3ABD A;  5C50 B;  4EXT C;  1GO4 A;  4GK5 A;  4TZN A; 
#chains in the Genus database with same CATH topology
 4AEZ B;  2VFX A;  4TRK A;  3GMH A;  4TZL A;  2QYF A;  4GK0 A;  2QYF B;  3VU7 C;  5LCW Z;  4FJO C;  4YK8 B;  4TZS A;  4TZJ A;  2V64 A;  1DUJ A;  1KLQ A;  2V64 D;  4TZO A;  3ABE C;  4TZQ A;  4J2G A;  4TZM A;  1S2H A;  3ABD A;  5C50 B;  4EXT C;  1GO4 A;  4GK5 A;  4TZN A; 
#chains in the Genus database with same CATH homology
 4AEZ B;  2VFX A;  4TRK A;  3GMH A;  4TZL A;  2QYF A;  4GK0 A;  3VU7 C;  5LCW Z;  4FJO C;  4YK8 B;  4TZS A;  4TZJ A;  2V64 A;  1DUJ A;  1KLQ A;  2V64 D;  4TZO A;  3ABE C;  4TZQ A;  4J2G A;  4TZM A;  1S2H A;  3ABD A;  5C50 B;  4EXT C;  1GO4 A;  4GK5 A;  4TZN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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