2VFXA

Structure of the symmetric mad2 dimer
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
206
structure length
203
Chain Sequence
GMALQLSREQGITARGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKSSVQKLVVVISNIESGEVLERWQFDIESDKTASAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
total genus 57
structure length 203
sequence length 206
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L
ec nomenclature
pdb deposition date 2007-11-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 2vfxA00
4TZQA 1GO4A 2V64A 4TZJA 4AEZB 3GMHA 3ABDA 1DUJA 4TZNA 4EXTC 4GK0A 4TZMA 4J2GA 5LCWZ 2QYFA 2V64D 4YK8B 4FJOC 1KLQA 4TZLA 3VU7C 4TRKA 1S2HA 4TZOA 2VFXA 4GK5A 4TZSA 5C50B 3ABEC
chains in the Genus database with same CATH superfamily
2QYFB 4TZQA 1GO4A 2V64A 4TZJA 4AEZB 3GMHA 3ABDA 1DUJA 4TZNA 4EXTC 4GK0A 4TZMA 4J2GA 5LCWZ 2QYFA 2V64D 4YK8B 4FJOC 1KLQA 4TZLA 3VU7C 4TRKA 1S2HA 4TZOA 2VFXA 4GK5A 4TZSA 5C50B 3ABEC
chains in the Genus database with same CATH topology
4TZQA 1GO4A 2V64A 4TZJA 4AEZB 3GMHA 3ABDA 1DUJA 4TZNA 4EXTC 4GK0A 4TZMA 4J2GA 5LCWZ 2QYFA 2V64D 4YK8B 4FJOC 1KLQA 4TZLA 3VU7C 4TRKA 1S2HA 4TZOA 2VFXA 4GK5A 4TZSA 5C50B 3ABEC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZQ A;  1GO4 A;  2V64 A;  4TZJ A;  4AEZ B;  3GMH A;  3ABD A;  1DUJ A;  4TZN A;  4EXT C;  4GK0 A;  4TZM A;  4J2G A;  5LCW Z;  2QYF A;  2V64 D;  4YK8 B;  4FJO C;  1KLQ A;  4TZL A;  3VU7 C;  4TRK A;  1S2H A;  4TZO A;  2VFX A;  4GK5 A;  4TZS A;  5C50 B;  3ABE C; 
#chains in the Genus database with same CATH topology
 2QYF B;  4TZQ A;  1GO4 A;  2V64 A;  4TZJ A;  4AEZ B;  3GMH A;  3ABD A;  1DUJ A;  4TZN A;  4EXT C;  4GK0 A;  4TZM A;  4J2G A;  5LCW Z;  2QYF A;  2V64 D;  4YK8 B;  4FJO C;  1KLQ A;  4TZL A;  3VU7 C;  4TRK A;  1S2H A;  4TZO A;  2VFX A;  4GK5 A;  4TZS A;  5C50 B;  3ABE C; 
#chains in the Genus database with same CATH homology
 4TZQ A;  1GO4 A;  2V64 A;  4TZJ A;  4AEZ B;  3GMH A;  3ABD A;  1DUJ A;  4TZN A;  4EXT C;  4GK0 A;  4TZM A;  4J2G A;  5LCW Z;  2QYF A;  2V64 D;  4YK8 B;  4FJO C;  1KLQ A;  4TZL A;  3VU7 C;  4TRK A;  1S2H A;  4TZO A;  2VFX A;  4GK5 A;  4TZS A;  5C50 B;  3ABE C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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