2V64A

Crystallographic structure of the conformational dimer of the spindle assembly checkpoint protein mad2.
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
Knots found
sequence length
210
structure length
210
Chain Sequence
HHHHHGSALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
publication title The MAD2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
pubmed doi rcsb
source organism Homo sapiens
total genus 64
structure length 210
sequence length 210
chains with identical sequence C, F
other databases KnotProt 2.0: S +31
ec nomenclature
pdb deposition date 2007-07-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 2v64A00
4TZSA 5C50B 4J2GA 4TZQA 4TZLA 4TZMA 4AEZB 1DUJA 1KLQA 4GK5A 1S2HA 4TZNA 4TRKA 3VU7C 2VFXA 1GO4A 4GK0A 4YK8B 4TZOA 2V64D 4EXTC 4TZJA 5LCWZ 3ABDA 4FJOC 2QYFA 3GMHA 2V64A 3ABEC
chains in the Genus database with same CATH superfamily
4TZSA 5C50B 4J2GA 4TZQA 4TZLA 4TZMA 4AEZB 1DUJA 1KLQA 4GK5A 1S2HA 4TZNA 4TRKA 2QYFB 3VU7C 2VFXA 1GO4A 4GK0A 4YK8B 4TZOA 2V64D 4EXTC 4TZJA 5LCWZ 3ABDA 4FJOC 2QYFA 3GMHA 2V64A 3ABEC
chains in the Genus database with same CATH topology
4TZSA 5C50B 4J2GA 4TZQA 4TZLA 4TZMA 4AEZB 1DUJA 1KLQA 4GK5A 1S2HA 4TZNA 4TRKA 3VU7C 2VFXA 1GO4A 4GK0A 4YK8B 4TZOA 2V64D 4EXTC 4TZJA 5LCWZ 3ABDA 4FJOC 2QYFA 3GMHA 2V64A 3ABEC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TZS A;  5C50 B;  4J2G A;  4TZQ A;  4TZL A;  4TZM A;  4AEZ B;  1DUJ A;  1KLQ A;  4GK5 A;  1S2H A;  4TZN A;  4TRK A;  3VU7 C;  2VFX A;  1GO4 A;  4GK0 A;  4YK8 B;  4TZO A;  2V64 D;  4EXT C;  4TZJ A;  5LCW Z;  3ABD A;  4FJO C;  2QYF A;  3GMH A;  2V64 A;  3ABE C; 
#chains in the Genus database with same CATH topology
 4TZS A;  5C50 B;  4J2G A;  4TZQ A;  4TZL A;  4TZM A;  4AEZ B;  1DUJ A;  1KLQ A;  4GK5 A;  1S2H A;  4TZN A;  4TRK A;  2QYF B;  3VU7 C;  2VFX A;  1GO4 A;  4GK0 A;  4YK8 B;  4TZO A;  2V64 D;  4EXT C;  4TZJ A;  5LCW Z;  3ABD A;  4FJO C;  2QYF A;  3GMH A;  2V64 A;  3ABE C; 
#chains in the Genus database with same CATH homology
 4TZS A;  5C50 B;  4J2G A;  4TZQ A;  4TZL A;  4TZM A;  4AEZ B;  1DUJ A;  1KLQ A;  4GK5 A;  1S2H A;  4TZN A;  4TRK A;  3VU7 C;  2VFX A;  1GO4 A;  4GK0 A;  4YK8 B;  4TZO A;  2V64 D;  4EXT C;  4TZJ A;  5LCW Z;  3ABD A;  4FJO C;  2QYF A;  3GMH A;  2V64 A;  3ABE C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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