2V64A

Crystallographic structure of the conformational dimer of the spindle assembly checkpoint protein mad2.
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
Knots found
sequence length
210
structure length
210
Chain Sequence
HHHHHGSALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The MAD2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
pubmed doi rcsb
molecule keywords MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
molecule tags Cell cycle
source organism Homo sapiens
total genus 64
structure length 210
sequence length 210
chains with identical sequence C, F
other databases KnotProt 2.0: S +31
ec nomenclature
pdb deposition date 2007-07-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 2v64A00
2V64D 4TZJA 4YK8B 4TZSA 3GMHA 4AEZB 3ABEC 1DUJA 5C50B 4TZLA 4TZOA 4FJOC 3VU7C 4TZMA 2VFXA 3ABDA 4TZQA 2V64A 4GK5A 4TZNA 4GK0A 5LCWZ 4TRKA 4J2GA 2QYFA 4EXTC 1KLQA 1GO4A 1S2HA
chains in the Genus database with same CATH superfamily
2V64D 4TZJA 4YK8B 4TZSA 3GMHA 4AEZB 3ABEC 1DUJA 5C50B 2QYFB 4TZLA 4TZOA 4FJOC 3VU7C 4TZMA 2VFXA 3ABDA 4TZQA 2V64A 4GK5A 4TZNA 4GK0A 5LCWZ 4TRKA 4J2GA 2QYFA 4EXTC 1KLQA 1GO4A 1S2HA
chains in the Genus database with same CATH topology
2V64D 4TZJA 4YK8B 4TZSA 3GMHA 4AEZB 3ABEC 1DUJA 5C50B 4TZLA 4TZOA 4FJOC 3VU7C 4TZMA 2VFXA 3ABDA 4TZQA 2V64A 4GK5A 4TZNA 4GK0A 5LCWZ 4TRKA 4J2GA 2QYFA 4EXTC 1KLQA 1GO4A 1S2HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V64 D;  4TZJ A;  4YK8 B;  4TZS A;  3GMH A;  4AEZ B;  3ABE C;  1DUJ A;  5C50 B;  4TZL A;  4TZO A;  4FJO C;  3VU7 C;  4TZM A;  2VFX A;  3ABD A;  4TZQ A;  2V64 A;  4GK5 A;  4TZN A;  4GK0 A;  5LCW Z;  4TRK A;  4J2G A;  2QYF A;  4EXT C;  1KLQ A;  1GO4 A;  1S2H A; 
#chains in the Genus database with same CATH topology
 2V64 D;  4TZJ A;  4YK8 B;  4TZS A;  3GMH A;  4AEZ B;  3ABE C;  1DUJ A;  5C50 B;  2QYF B;  4TZL A;  4TZO A;  4FJO C;  3VU7 C;  4TZM A;  2VFX A;  3ABD A;  4TZQ A;  2V64 A;  4GK5 A;  4TZN A;  4GK0 A;  5LCW Z;  4TRK A;  4J2G A;  2QYF A;  4EXT C;  1KLQ A;  1GO4 A;  1S2H A; 
#chains in the Genus database with same CATH homology
 2V64 D;  4TZJ A;  4YK8 B;  4TZS A;  3GMH A;  4AEZ B;  3ABE C;  1DUJ A;  5C50 B;  4TZL A;  4TZO A;  4FJO C;  3VU7 C;  4TZM A;  2VFX A;  3ABD A;  4TZQ A;  2V64 A;  4GK5 A;  4TZN A;  4GK0 A;  5LCW Z;  4TRK A;  4J2G A;  2QYF A;  4EXT C;  1KLQ A;  1GO4 A;  1S2H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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