2ZXWA

Bovine heart cytochrome c oxidase at the fully oxidized state (1-s x-ray exposure dataset)
Total Genus 204
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
204
sequence length
513
structure length
513
Chain Sequence
FINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Cytochrome c oxidase subunit 1
total genus 204
structure length 513
sequence length 513
chains with identical sequence N
ec nomenclature ec 1.9.3.1: Cytochrome-c oxidase.
pdb deposition date 2009-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00115 COX1 Cytochrome C and Quinol oxidase polypeptide I
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.210.10 Mainly Alpha Up-down Bundle Cytochrome C Oxidase; Chain A Cytochrome c oxidase-like, subunit I domain 2zxwA00
3EH4A 3MK7A 4G70A 3FYIA 4G72A 3ASNA 3ASOA 2ZXWA 2EINA 4GP8A 3FYEA 3QJTA 3AG4A 2QPDA 3QJQA 5DJQA 2EIKA 1QLEA 2DYRA 3EH5A 4G7RA 3OM3A 4G7QA 2QPEA 3OMAA 3QJRA 1AR1A 1M56A 3OMNA 2OCCA 3EH3A 1XMEA 3ABMA 3AG1A 1OCRA 3WG7A 3AG2A 3OMIA 1FFTA 3S3CA 3WFEB 4FAAA 2EIMA 3WFBB 3WFCB 4GP4A 4G71A 3DTUA 4N4YA 1OCZA 4G7SA 2YEVA 4XYDA 3S8GA 3AYFA 1OCCA 5B3SA 3WFDB 5B1BA 5B1AA 2DYSA 3ABKA 2Y69A 3EHBA 4FA7A 3QJUA 3QJVA 3S3BA 1V54A 3ABLA 1EHKA 2GSMA 3O0RB 3S8FA 1OCOA 3AYGA 4GP5A 3AG3A 3HB3A 1V55A 2EILA 1M57A 5IY5A 3S3DA 3QJSA 3BVDA 3X2QA 2EIJA
chains in the Genus database with same CATH superfamily
3EH4A 3MK7A 4G70A 3FYIA 4G72A 3ASNA 3ASOA 2ZXWA 2EINA 4GP8A 3FYEA 3QJTA 3AG4A 2QPDA 3QJQA 5DJQA 2EIKA 1QLEA 2DYRA 3EH5A 4G7RA 3OM3A 4G7QA 2QPEA 3OMAA 3QJRA 1AR1A 1M56A 3OMNA 2OCCA 3EH3A 1XMEA 3ABMA 3AG1A 1OCRA 3WG7A 3AG2A 3OMIA 1FFTA 3S3CA 3WFEB 4FAAA 2EIMA 3WFBB 3WFCB 4GP4A 4G71A 3DTUA 4N4YA 1OCZA 4G7SA 2YEVA 4XYDA 3S8GA 3AYFA 1OCCA 5B3SA 3WFDB 5B1BA 5B1AA 2DYSA 3ABKA 2Y69A 3EHBA 4FA7A 3QJUA 3QJVA 3S3BA 1V54A 3ABLA 1EHKA 2GSMA 3O0RB 3S8FA 1OCOA 3AYGA 4GP5A 3AG3A 3HB3A 1V55A 2EILA 1M57A 5IY5A 3S3DA 3QJSA 3BVDA 3X2QA 2EIJA
chains in the Genus database with same CATH topology
3EH4A 3MK7A 4G70A 3FYIA 4G72A 3ASNA 3ASOA 2ZXWA 2EINA 4GP8A 3FYEA 3QJTA 3AG4A 2QPDA 3QJQA 5DJQA 2EIKA 1QLEA 2DYRA 3EH5A 4G7RA 3OM3A 4G7QA 2QPEA 3OMAA 3QJRA 1AR1A 1M56A 3OMNA 2OCCA 3EH3A 1XMEA 3ABMA 3AG1A 1OCRA 3WG7A 3AG2A 3OMIA 1FFTA 3S3CA 3WFEB 4FAAA 2EIMA 3WFBB 3WFCB 4GP4A 4G71A 3DTUA 4N4YA 1OCZA 4G7SA 2YEVA 4XYDA 3S8GA 3AYFA 1OCCA 5B3SA 3WFDB 5B1BA 5B1AA 2DYSA 3ABKA 2Y69A 3EHBA 4FA7A 3QJUA 3QJVA 3S3BA 1V54A 3ABLA 1EHKA 2GSMA 3O0RB 3S8FA 1OCOA 3AYGA 4GP5A 3AG3A 3HB3A 1V55A 2EILA 1M57A 5IY5A 3S3DA 3QJSA 3BVDA 3X2QA 2EIJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EH4 A;  3MK7 A;  4G70 A;  3FYI A;  4G72 A;  3ASN A;  3ASO A;  2ZXW A;  2EIN A;  4GP8 A;  3FYE A;  3QJT A;  3AG4 A;  2QPD A;  3QJQ A;  5DJQ A;  2EIK A;  1QLE A;  2DYR A;  3EH5 A;  4G7R A;  3OM3 A;  4G7Q A;  2QPE A;  3OMA A;  3QJR A;  1AR1 A;  1M56 A;  3OMN A;  2OCC A;  3EH3 A;  1XME A;  3ABM A;  3AG1 A;  1OCR A;  3WG7 A;  3AG2 A;  3OMI A;  1FFT A;  3S3C A;  3WFE B;  4FAA A;  2EIM A;  3WFB B;  3WFC B;  4GP4 A;  4G71 A;  3DTU A;  4N4Y A;  1OCZ A;  4G7S A;  2YEV A;  4XYD A;  3S8G A;  3AYF A;  1OCC A;  5B3S A;  3WFD B;  5B1B A;  5B1A A;  2DYS A;  3ABK A;  2Y69 A;  3EHB A;  4FA7 A;  3QJU A;  3QJV A;  3S3B A;  1V54 A;  3ABL A;  1EHK A;  2GSM A;  3O0R B;  3S8F A;  1OCO A;  3AYG A;  4GP5 A;  3AG3 A;  3HB3 A;  1V55 A;  2EIL A;  1M57 A;  5IY5 A;  3S3D A;  3QJS A;  3BVD A;  3X2Q A;  2EIJ A; 
#chains in the Genus database with same CATH topology
 3EH4 A;  3MK7 A;  4G70 A;  3FYI A;  4G72 A;  3ASN A;  3ASO A;  2ZXW A;  2EIN A;  4GP8 A;  3FYE A;  3QJT A;  3AG4 A;  2QPD A;  3QJQ A;  5DJQ A;  2EIK A;  1QLE A;  2DYR A;  3EH5 A;  4G7R A;  3OM3 A;  4G7Q A;  2QPE A;  3OMA A;  3QJR A;  1AR1 A;  1M56 A;  3OMN A;  2OCC A;  3EH3 A;  1XME A;  3ABM A;  3AG1 A;  1OCR A;  3WG7 A;  3AG2 A;  3OMI A;  1FFT A;  3S3C A;  3WFE B;  4FAA A;  2EIM A;  3WFB B;  3WFC B;  4GP4 A;  4G71 A;  3DTU A;  4N4Y A;  1OCZ A;  4G7S A;  2YEV A;  4XYD A;  3S8G A;  3AYF A;  1OCC A;  5B3S A;  3WFD B;  5B1B A;  5B1A A;  2DYS A;  3ABK A;  2Y69 A;  3EHB A;  4FA7 A;  3QJU A;  3QJV A;  3S3B A;  1V54 A;  3ABL A;  1EHK A;  2GSM A;  3O0R B;  3S8F A;  1OCO A;  3AYG A;  4GP5 A;  3AG3 A;  3HB3 A;  1V55 A;  2EIL A;  1M57 A;  5IY5 A;  3S3D A;  3QJS A;  3BVD A;  3X2Q A;  2EIJ A; 
#chains in the Genus database with same CATH homology
 3EH4 A;  3MK7 A;  4G70 A;  3FYI A;  4G72 A;  3ASN A;  3ASO A;  2ZXW A;  2EIN A;  4GP8 A;  3FYE A;  3QJT A;  3AG4 A;  2QPD A;  3QJQ A;  5DJQ A;  2EIK A;  1QLE A;  2DYR A;  3EH5 A;  4G7R A;  3OM3 A;  4G7Q A;  2QPE A;  3OMA A;  3QJR A;  1AR1 A;  1M56 A;  3OMN A;  2OCC A;  3EH3 A;  1XME A;  3ABM A;  3AG1 A;  1OCR A;  3WG7 A;  3AG2 A;  3OMI A;  1FFT A;  3S3C A;  3WFE B;  4FAA A;  2EIM A;  3WFB B;  3WFC B;  4GP4 A;  4G71 A;  3DTU A;  4N4Y A;  1OCZ A;  4G7S A;  2YEV A;  4XYD A;  3S8G A;  3AYF A;  1OCC A;  5B3S A;  3WFD B;  5B1B A;  5B1A A;  2DYS A;  3ABK A;  2Y69 A;  3EHB A;  4FA7 A;  3QJU A;  3QJV A;  3S3B A;  1V54 A;  3ABL A;  1EHK A;  2GSM A;  3O0R B;  3S8F A;  1OCO A;  3AYG A;  4GP5 A;  3AG3 A;  3HB3 A;  1V55 A;  2EIL A;  1M57 A;  5IY5 A;  3S3D A;  3QJS A;  3BVD A;  3X2Q A;  2EIJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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