3E4AA

Human ide-inhibitor complex at 2.6 angstrom resolution
Total Genus 349
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
349
sequence length
969
structure length
961
Chain Sequence
NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNPVVGNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Hydrolase
molecule keywords Insulin-degrading enzyme
publication title Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
pubmed doi rcsb
source organism Homo sapiens
total genus 349
structure length 961
sequence length 969
chains with identical sequence B
ec nomenclature ec 3.4.24.56: Insulysin.
pdb deposition date 2008-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00675 Peptidase_M16 Insulinase (Peptidase family M16)
A PF05193 Peptidase_M16_C Peptidase M16 inactive domain
A PF16187 Peptidase_M16_M Middle or third domain of peptidase_M16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3e4aA03
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3e4aA04
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3e4aA02
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3e4aA01
1P84B 3L73B 4L3TA 1EZVB 4U3FA 3L72A 3H1IA 5KLVB 2FYUB 1NU1A 1HR6A 2G49A 2WBYA 1KYOA 3HDIA 3CWWA 1SQQB 4XEAA 1BGYB 3CX5B 1NTKB 4PF9A 1SQPB 3CWBA 4PF7A 3L71B 4NGED 2JG4A 1L0NB 4D6TB 4NNZA 3TGUB 4RPUB 3L74A 4PD4B 1BE3A 3L70A 4L3TB 4U3FB 3AMJA 1NTZA 3L72B 3E4AA 4RE9A 1NU1B 1PP9A 2JBUA 1HR6B 3AMIA 1KYOB 3CXHA 3H1KA 1HR9A 3TUVA 1HR7A 2WK3A 1HR8A 3GO9A 5CJOA 4PESA 4GS8A 1NTMA 1L0LA 4DWKA 4NGEA 3OFIA 1KB9B 3GWBA 3L75A 3CWBB 5EUFA 2A06B 3L74B 1SQXA 1SQBA 2BCCA 4PFCA 1BE3B 3L70B 4GSFA 3N56A 1NTZB 3BCCA 1EZVA 2G47A 4M1CA 2YPUA 3H1IB 3H1HA 2G56A 1PP9B 3QZ2A 3CXHB 3H1KB 1HR9B 3N57A 4DTTA 1HR7B 3E50A 3P7OA 1HR8B 2G54A 4QIAA 2IBZA 1BGYA 4RALA 3H44A 1L0LB 3IVLA 3H1LA 1NTKA 4D6TO 1L0NA 1PPJA 1SQVA 3H1JA 4PD4A 1BCCA 3IH6A 3BCCB 3HGZA 3AMJB 4IFHA 4LTEA 1P84A 3L73A 3H1HB 3D3YA 2WC0A 5KLVA 2FYUA 4GSCA 2FGEA 2IBZB 2G48A 1SQQA 1NTMB 1Q2LA 3H1LB 4NXOA 3P7LA 3CX5A 1KB9A 3L75B 3EOQA 1SQPA 4IOFA 3E4ZA 1PPJB 2A06A 1SQVB 3H1JB 3L71A 1BCCB 4D6TA 1SQXB 3TGUA 1SQBB 2BCCB 4RPUA
chains in the Genus database with same CATH superfamily
1P84B 3L73B 4L3TA 1EZVB 4U3FA 3L72A 3H1IA 5KLVB 2FYUB 1NU1A 1HR6A 2G49A 2WBYA 1KYOA 3HDIA 3CWWA 1SQQB 4XEAA 1BGYB 3CX5B 1NTKB 4PF9A 1SQPB 3CWBA 4PF7A 3L71B 4NGED 2JG4A 1L0NB 4D6TB 4NNZA 3TGUB 4RPUB 3L74A 4PD4B 1BE3A 3L70A 4L3TB 4U3FB 3AMJA 1NTZA 3L72B 3E4AA 4RE9A 1NU1B 1PP9A 2JBUA 1HR6B 3AMIA 1KYOB 3CXHA 3H1KA 1HR9A 3TUVA 1HR7A 2WK3A 1HR8A 3GO9A 5CJOA 4PESA 4GS8A 1NTMA 1L0LA 4DWKA 4NGEA 3OFIA 1KB9B 3GWBA 3L75A 3CWBB 5EUFA 2A06B 3L74B 1SQXA 1SQBA 2BCCA 4PFCA 1BE3B 3L70B 4GSFA 3N56A 1NTZB 3BCCA 1EZVA 2G47A 4M1CA 2YPUA 3H1IB 3H1HA 2G56A 1PP9B 3QZ2A 3CXHB 3H1KB 1HR9B 3N57A 4DTTA 1HR7B 3E50A 3P7OA 1HR8B 2G54A 4QIAA 2IBZA 1BGYA 4RALA 3H44A 1L0LB 3IVLA 3H1LA 1NTKA 4D6TO 1L0NA 1PPJA 1SQVA 3H1JA 4PD4A 1BCCA 3IH6A 3BCCB 3HGZA 3AMJB 4IFHA 4LTEA 1P84A 3L73A 3H1HB 3D3YA 2WC0A 5KLVA 2FYUA 4GSCA 2FGEA 2IBZB 2G48A 1SQQA 1NTMB 1Q2LA 3H1LB 4NXOA 3P7LA 3CX5A 1KB9A 3L75B 3EOQA 1SQPA 4IOFA 3E4ZA 1PPJB 2A06A 1SQVB 3H1JB 3L71A 1BCCB 4D6TA 1SQXB 3TGUA 1SQBB 2BCCB 4RPUA
chains in the Genus database with same CATH topology
1P84B 3L73B 4L3TA 1EZVB 4U3FA 3L72A 3H1IA 5KLVB 2FYUB 1NU1A 1HR6A 2G49A 2WBYA 1KYOA 3HDIA 3CWWA 1SQQB 4XEAA 1BGYB 3CX5B 1NTKB 4PF9A 1SQPB 3CWBA 4PF7A 3L71B 4NGED 2JG4A 1L0NB 4D6TB 4NNZA 3TGUB 4RPUB 3L74A 4PD4B 1BE3A 3L70A 4L3TB 4U3FB 3AMJA 1NTZA 3L72B 3E4AA 4RE9A 1NU1B 1PP9A 2JBUA 1HR6B 3AMIA 1KYOB 3CXHA 3H1KA 1HR9A 3TUVA 1HR7A 2WK3A 1HR8A 3GO9A 5CJOA 4PESA 4GS8A 1NTMA 1L0LA 4DWKA 4NGEA 3OFIA 1KB9B 3GWBA 3L75A 3CWBB 5EUFA 2A06B 3L74B 1SQXA 1SQBA 2BCCA 4PFCA 1BE3B 3L70B 4GSFA 3N56A 1NTZB 3BCCA 1EZVA 2G47A 4M1CA 2YPUA 3H1IB 3H1HA 2G56A 1PP9B 3QZ2A 3CXHB 3H1KB 1HR9B 3N57A 4DTTA 1HR7B 3E50A 3P7OA 1HR8B 2G54A 4QIAA 2IBZA 1BGYA 4RALA 3H44A 1L0LB 3IVLA 3H1LA 1NTKA 4D6TO 1L0NA 1PPJA 1SQVA 3H1JA 4PD4A 1BCCA 3IH6A 3BCCB 3HGZA 3AMJB 4IFHA 4LTEA 1P84A 3L73A 3H1HB 3D3YA 2WC0A 5KLVA 2FYUA 4GSCA 2FGEA 2IBZB 2G48A 1SQQA 1NTMB 1Q2LA 3H1LB 4NXOA 3P7LA 3CX5A 1KB9A 3L75B 3EOQA 1SQPA 4IOFA 3E4ZA 1PPJB 2A06A 1SQVB 3H1JB 3L71A 1BCCB 4D6TA 1SQXB 3TGUA 1SQBB 2BCCB 4RPUA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1P84 B;  3L73 B;  4L3T A;  1EZV B;  4U3F A;  3L72 A;  3H1I A;  5KLV B;  2FYU B;  1NU1 A;  1HR6 A;  2G49 A;  2WBY A;  1KYO A;  3HDI A;  3CWW A;  1SQQ B;  4XEA A;  1BGY B;  3CX5 B;  1NTK B;  4PF9 A;  1SQP B;  3CWB A;  4PF7 A;  3L71 B;  4NGE D;  2JG4 A;  1L0N B;  4D6T B;  4NNZ A;  3TGU B;  4RPU B;  3L74 A;  4PD4 B;  1BE3 A;  3L70 A;  4L3T B;  4U3F B;  3AMJ A;  1NTZ A;  3L72 B;  3E4A A;  4RE9 A;  1NU1 B;  1PP9 A;  2JBU A;  1HR6 B;  3AMI A;  1KYO B;  3CXH A;  3H1K A;  1HR9 A;  3TUV A;  1HR7 A;  2WK3 A;  1HR8 A;  3GO9 A;  5CJO A;  4PES A;  4GS8 A;  1NTM A;  1L0L A;  4DWK A;  4NGE A;  3OFI A;  1KB9 B;  3GWB A;  3L75 A;  3CWB B;  5EUF A;  2A06 B;  3L74 B;  1SQX A;  1SQB A;  2BCC A;  4PFC A;  1BE3 B;  3L70 B;  4GSF A;  3N56 A;  1NTZ B;  3BCC A;  1EZV A;  2G47 A;  4M1C A;  2YPU A;  3H1I B;  3H1H A;  2G56 A;  1PP9 B;  3QZ2 A;  3CXH B;  3H1K B;  1HR9 B;  3N57 A;  4DTT A;  1HR7 B;  3E50 A;  3P7O A;  1HR8 B;  2G54 A;  4QIA A;  2IBZ A;  1BGY A;  4RAL A;  3H44 A;  1L0L B;  3IVL A;  3H1L A;  1NTK A;  4D6T O;  1L0N A;  1PPJ A;  1SQV A;  3H1J A;  4PD4 A;  1BCC A;  3IH6 A;  3BCC B;  3HGZ A;  3AMJ B;  4IFH A;  4LTE A;  1P84 A;  3L73 A;  3H1H B;  3D3Y A;  2WC0 A;  5KLV A;  2FYU A;  4GSC A;  2FGE A;  2IBZ B;  2G48 A;  1SQQ A;  1NTM B;  1Q2L A;  3H1L B;  4NXO A;  3P7L A;  3CX5 A;  1KB9 A;  3L75 B;  3EOQ A;  1SQP A;  4IOF A;  3E4Z A;  1PPJ B;  2A06 A;  1SQV B;  3H1J B;  3L71 A;  1BCC B;  4D6T A;  1SQX B;  3TGU A;  1SQB B;  2BCC B;  4RPU A; 
#chains in the Genus database with same CATH topology
 1P84 B;  3L73 B;  4L3T A;  1EZV B;  4U3F A;  3L72 A;  3H1I A;  5KLV B;  2FYU B;  1NU1 A;  1HR6 A;  2G49 A;  2WBY A;  1KYO A;  3HDI A;  3CWW A;  1SQQ B;  4XEA A;  1BGY B;  3CX5 B;  1NTK B;  4PF9 A;  1SQP B;  3CWB A;  4PF7 A;  3L71 B;  4NGE D;  2JG4 A;  1L0N B;  4D6T B;  4NNZ A;  3TGU B;  4RPU B;  3L74 A;  4PD4 B;  1BE3 A;  3L70 A;  4L3T B;  4U3F B;  3AMJ A;  1NTZ A;  3L72 B;  3E4A A;  4RE9 A;  1NU1 B;  1PP9 A;  2JBU A;  1HR6 B;  3AMI A;  1KYO B;  3CXH A;  3H1K A;  1HR9 A;  3TUV A;  1HR7 A;  2WK3 A;  1HR8 A;  3GO9 A;  5CJO A;  4PES A;  4GS8 A;  1NTM A;  1L0L A;  4DWK A;  4NGE A;  3OFI A;  1KB9 B;  3GWB A;  3L75 A;  3CWB B;  5EUF A;  2A06 B;  3L74 B;  1SQX A;  1SQB A;  2BCC A;  4PFC A;  1BE3 B;  3L70 B;  4GSF A;  3N56 A;  1NTZ B;  3BCC A;  1EZV A;  2G47 A;  4M1C A;  2YPU A;  3H1I B;  3H1H A;  2G56 A;  1PP9 B;  3QZ2 A;  3CXH B;  3H1K B;  1HR9 B;  3N57 A;  4DTT A;  1HR7 B;  3E50 A;  3P7O A;  1HR8 B;  2G54 A;  4QIA A;  2IBZ A;  1BGY A;  4RAL A;  3H44 A;  1L0L B;  3IVL A;  3H1L A;  1NTK A;  4D6T O;  1L0N A;  1PPJ A;  1SQV A;  3H1J A;  4PD4 A;  1BCC A;  3IH6 A;  3BCC B;  3HGZ A;  3AMJ B;  4IFH A;  4LTE A;  1P84 A;  3L73 A;  3H1H B;  3D3Y A;  2WC0 A;  5KLV A;  2FYU A;  4GSC A;  2FGE A;  2IBZ B;  2G48 A;  1SQQ A;  1NTM B;  1Q2L A;  3H1L B;  4NXO A;  3P7L A;  3CX5 A;  1KB9 A;  3L75 B;  3EOQ A;  1SQP A;  4IOF A;  3E4Z A;  1PPJ B;  2A06 A;  1SQV B;  3H1J B;  3L71 A;  1BCC B;  4D6T A;  1SQX B;  3TGU A;  1SQB B;  2BCC B;  4RPU A; 
#chains in the Genus database with same CATH homology
 1P84 B;  3L73 B;  4L3T A;  1EZV B;  4U3F A;  3L72 A;  3H1I A;  5KLV B;  2FYU B;  1NU1 A;  1HR6 A;  2G49 A;  2WBY A;  1KYO A;  3HDI A;  3CWW A;  1SQQ B;  4XEA A;  1BGY B;  3CX5 B;  1NTK B;  4PF9 A;  1SQP B;  3CWB A;  4PF7 A;  3L71 B;  4NGE D;  2JG4 A;  1L0N B;  4D6T B;  4NNZ A;  3TGU B;  4RPU B;  3L74 A;  4PD4 B;  1BE3 A;  3L70 A;  4L3T B;  4U3F B;  3AMJ A;  1NTZ A;  3L72 B;  3E4A A;  4RE9 A;  1NU1 B;  1PP9 A;  2JBU A;  1HR6 B;  3AMI A;  1KYO B;  3CXH A;  3H1K A;  1HR9 A;  3TUV A;  1HR7 A;  2WK3 A;  1HR8 A;  3GO9 A;  5CJO A;  4PES A;  4GS8 A;  1NTM A;  1L0L A;  4DWK A;  4NGE A;  3OFI A;  1KB9 B;  3GWB A;  3L75 A;  3CWB B;  5EUF A;  2A06 B;  3L74 B;  1SQX A;  1SQB A;  2BCC A;  4PFC A;  1BE3 B;  3L70 B;  4GSF A;  3N56 A;  1NTZ B;  3BCC A;  1EZV A;  2G47 A;  4M1C A;  2YPU A;  3H1I B;  3H1H A;  2G56 A;  1PP9 B;  3QZ2 A;  3CXH B;  3H1K B;  1HR9 B;  3N57 A;  4DTT A;  1HR7 B;  3E50 A;  3P7O A;  1HR8 B;  2G54 A;  4QIA A;  2IBZ A;  1BGY A;  4RAL A;  3H44 A;  1L0L B;  3IVL A;  3H1L A;  1NTK A;  4D6T O;  1L0N A;  1PPJ A;  1SQV A;  3H1J A;  4PD4 A;  1BCC A;  3IH6 A;  3BCC B;  3HGZ A;  3AMJ B;  4IFH A;  4LTE A;  1P84 A;  3L73 A;  3H1H B;  3D3Y A;  2WC0 A;  5KLV A;  2FYU A;  4GSC A;  2FGE A;  2IBZ B;  2G48 A;  1SQQ A;  1NTM B;  1Q2L A;  3H1L B;  4NXO A;  3P7L A;  3CX5 A;  1KB9 A;  3L75 B;  3EOQ A;  1SQP A;  4IOF A;  3E4Z A;  1PPJ B;  2A06 A;  1SQV B;  3H1J B;  3L71 A;  1BCC B;  4D6T A;  1SQX B;  3TGU A;  1SQB B;  2BCC B;  4RPU A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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