3HGZA

Crystal structure of human insulin-degrading enzyme in complex with amylin
Total Genus 352
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
352
sequence length
969
structure length
958
Chain Sequence
NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNPNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Hydrolase
molecule keywords Insulin-degrading enzyme
publication title Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
pubmed doi rcsb
source organism Homo sapiens
total genus 352
structure length 958
sequence length 969
chains with identical sequence B
ec nomenclature ec 3.4.24.56: Insulysin.
pdb deposition date 2009-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00675 Peptidase_M16 Insulinase (Peptidase family M16)
A PF05193 Peptidase_M16_C Peptidase M16 inactive domain
A PF16187 Peptidase_M16_M Middle or third domain of peptidase_M16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3hgzA03
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3hgzA04
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3hgzA02
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3hgzA01
1P84B 3BCCB 1BE3B 2FGEA 3EOQA 3L73B 4RALA 1SQPB 1BE3A 3AMJB 5CJOA 3L71B 3L72A 1PPJB 3AMJA 2G54A 1NTKB 4RPUA 3H1JB 4DTTA 1NU1A 3E4AA 3L74B 3N56A 1NTKA 2A06A 1KB9B 4D6TB 2IBZB 4U3FB 4RE9A 1HR8A 4XEAA 1HR6B 1KB9A 3E4ZA 4U3FA 3OFIA 1PP9B 5KLVB 2YPUA 3AMIA 1BGYB 4GS8A 3CX5A 1SQXB 1PP9A 3N57A 4GSCA 1BGYA 3HGZA 3H1LA 3H44A 1SQXA 2JBUA 1KYOB 3H1KA 4PESA 3L75A 3TUVA 3L72B 3GO9A 1KYOA 1HR9B 4PF9A 2JG4A 2WK3A 1HR9A 4RPUB 1NU1B 2WBYA 2A06B 2G49A 1HR8B 4NGED 3L70B 4IFHA 4PF7A 3CX5B 3H1IB 1NTZA 3L70A 3IH6A 2FYUA 3H1LB 3H1IA 4L3TB 3CWBA 3H1KB 4GSFA 2BCCB 3L75B 3P7LA 3P7OA 1HR7A 4L3TA 4LTEA 4PFCA 1L0LA 1SQBB 2BCCA 1SQBA 4QIAA 1SQQB 1SQVA 1BCCB 1SQQA 3CXHA 2G47A 1BCCA 3TGUA 3E50A 4NNZA 1NTZB 1Q2LA 1L0NA 2FYUB 3GWBA 3CWBB 4M1CA 5KLVA 1EZVA 1NTMB 3D3YA 1P84A 1HR7B 3BCCA 1L0LB 1NTMA 3L73A 3QZ2A 1SQPA 3H1HB 4DWKA 3CWWA 3HDIA 3L71A 1SQVB 1PPJA 3H1HA 5EUFA 2WC0A 3CXHB 4IOFA 3H1JA 3L74A 3TGUB 4D6TA 2IBZA 2G56A 4PD4B 2G48A 1L0NB 1HR6A 3IVLA 4PD4A 4D6TO 4NXOA 1EZVB 4NGEA
chains in the Genus database with same CATH superfamily
1P84B 3BCCB 1BE3B 2FGEA 3EOQA 3L73B 4RALA 1SQPB 1BE3A 3AMJB 5CJOA 3L71B 3L72A 1PPJB 3AMJA 2G54A 1NTKB 4RPUA 3H1JB 4DTTA 1NU1A 3E4AA 3L74B 3N56A 1NTKA 2A06A 1KB9B 4D6TB 2IBZB 4U3FB 4RE9A 1HR8A 4XEAA 1HR6B 1KB9A 3E4ZA 4U3FA 3OFIA 1PP9B 5KLVB 2YPUA 3AMIA 1BGYB 4GS8A 3CX5A 1SQXB 1PP9A 3N57A 4GSCA 1BGYA 3HGZA 3H1LA 3H44A 1SQXA 2JBUA 1KYOB 3H1KA 4PESA 3L75A 3TUVA 3L72B 3GO9A 1KYOA 1HR9B 4PF9A 2JG4A 2WK3A 1HR9A 4RPUB 1NU1B 2WBYA 2A06B 2G49A 1HR8B 4NGED 3L70B 4IFHA 4PF7A 3CX5B 3H1IB 1NTZA 3L70A 3IH6A 2FYUA 3H1LB 3H1IA 4L3TB 3CWBA 3H1KB 4GSFA 2BCCB 3L75B 3P7LA 3P7OA 1HR7A 4L3TA 4LTEA 4PFCA 1L0LA 1SQBB 2BCCA 1SQBA 4QIAA 1SQQB 1SQVA 1BCCB 1SQQA 3CXHA 2G47A 1BCCA 3TGUA 3E50A 4NNZA 1NTZB 1Q2LA 1L0NA 2FYUB 3GWBA 3CWBB 4M1CA 5KLVA 1EZVA 1NTMB 3D3YA 1P84A 1HR7B 3BCCA 1L0LB 1NTMA 3L73A 3QZ2A 1SQPA 3H1HB 4DWKA 3CWWA 3HDIA 3L71A 1SQVB 1PPJA 3H1HA 5EUFA 2WC0A 3CXHB 4IOFA 3H1JA 3L74A 3TGUB 4D6TA 2IBZA 2G56A 4PD4B 2G48A 1L0NB 1HR6A 3IVLA 4PD4A 4D6TO 4NXOA 1EZVB 4NGEA
chains in the Genus database with same CATH topology
1P84B 3BCCB 1BE3B 2FGEA 3EOQA 3L73B 4RALA 1SQPB 1BE3A 3AMJB 5CJOA 3L71B 3L72A 1PPJB 3AMJA 2G54A 1NTKB 4RPUA 3H1JB 4DTTA 1NU1A 3E4AA 3L74B 3N56A 1NTKA 2A06A 1KB9B 4D6TB 2IBZB 4U3FB 4RE9A 1HR8A 4XEAA 1HR6B 1KB9A 3E4ZA 4U3FA 3OFIA 1PP9B 5KLVB 2YPUA 3AMIA 1BGYB 4GS8A 3CX5A 1SQXB 1PP9A 3N57A 4GSCA 1BGYA 3HGZA 3H1LA 3H44A 1SQXA 2JBUA 1KYOB 3H1KA 4PESA 3L75A 3TUVA 3L72B 3GO9A 1KYOA 1HR9B 4PF9A 2JG4A 2WK3A 1HR9A 4RPUB 1NU1B 2WBYA 2A06B 2G49A 1HR8B 4NGED 3L70B 4IFHA 4PF7A 3CX5B 3H1IB 1NTZA 3L70A 3IH6A 2FYUA 3H1LB 3H1IA 4L3TB 3CWBA 3H1KB 4GSFA 2BCCB 3L75B 3P7LA 3P7OA 1HR7A 4L3TA 4LTEA 4PFCA 1L0LA 1SQBB 2BCCA 1SQBA 4QIAA 1SQQB 1SQVA 1BCCB 1SQQA 3CXHA 2G47A 1BCCA 3TGUA 3E50A 4NNZA 1NTZB 1Q2LA 1L0NA 2FYUB 3GWBA 3CWBB 4M1CA 5KLVA 1EZVA 1NTMB 3D3YA 1P84A 1HR7B 3BCCA 1L0LB 1NTMA 3L73A 3QZ2A 1SQPA 3H1HB 4DWKA 3CWWA 3HDIA 3L71A 1SQVB 1PPJA 3H1HA 5EUFA 2WC0A 3CXHB 4IOFA 3H1JA 3L74A 3TGUB 4D6TA 2IBZA 2G56A 4PD4B 2G48A 1L0NB 1HR6A 3IVLA 4PD4A 4D6TO 4NXOA 1EZVB 4NGEA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1P84 B;  3BCC B;  1BE3 B;  2FGE A;  3EOQ A;  3L73 B;  4RAL A;  1SQP B;  1BE3 A;  3AMJ B;  5CJO A;  3L71 B;  3L72 A;  1PPJ B;  3AMJ A;  2G54 A;  1NTK B;  4RPU A;  3H1J B;  4DTT A;  1NU1 A;  3E4A A;  3L74 B;  3N56 A;  1NTK A;  2A06 A;  1KB9 B;  4D6T B;  2IBZ B;  4U3F B;  4RE9 A;  1HR8 A;  4XEA A;  1HR6 B;  1KB9 A;  3E4Z A;  4U3F A;  3OFI A;  1PP9 B;  5KLV B;  2YPU A;  3AMI A;  1BGY B;  4GS8 A;  3CX5 A;  1SQX B;  1PP9 A;  3N57 A;  4GSC A;  1BGY A;  3HGZ A;  3H1L A;  3H44 A;  1SQX A;  2JBU A;  1KYO B;  3H1K A;  4PES A;  3L75 A;  3TUV A;  3L72 B;  3GO9 A;  1KYO A;  1HR9 B;  4PF9 A;  2JG4 A;  2WK3 A;  1HR9 A;  4RPU B;  1NU1 B;  2WBY A;  2A06 B;  2G49 A;  1HR8 B;  4NGE D;  3L70 B;  4IFH A;  4PF7 A;  3CX5 B;  3H1I B;  1NTZ A;  3L70 A;  3IH6 A;  2FYU A;  3H1L B;  3H1I A;  4L3T B;  3CWB A;  3H1K B;  4GSF A;  2BCC B;  3L75 B;  3P7L A;  3P7O A;  1HR7 A;  4L3T A;  4LTE A;  4PFC A;  1L0L A;  1SQB B;  2BCC A;  1SQB A;  4QIA A;  1SQQ B;  1SQV A;  1BCC B;  1SQQ A;  3CXH A;  2G47 A;  1BCC A;  3TGU A;  3E50 A;  4NNZ A;  1NTZ B;  1Q2L A;  1L0N A;  2FYU B;  3GWB A;  3CWB B;  4M1C A;  5KLV A;  1EZV A;  1NTM B;  3D3Y A;  1P84 A;  1HR7 B;  3BCC A;  1L0L B;  1NTM A;  3L73 A;  3QZ2 A;  1SQP A;  3H1H B;  4DWK A;  3CWW A;  3HDI A;  3L71 A;  1SQV B;  1PPJ A;  3H1H A;  5EUF A;  2WC0 A;  3CXH B;  4IOF A;  3H1J A;  3L74 A;  3TGU B;  4D6T A;  2IBZ A;  2G56 A;  4PD4 B;  2G48 A;  1L0N B;  1HR6 A;  3IVL A;  4PD4 A;  4D6T O;  4NXO A;  1EZV B;  4NGE A; 
#chains in the Genus database with same CATH topology
 1P84 B;  3BCC B;  1BE3 B;  2FGE A;  3EOQ A;  3L73 B;  4RAL A;  1SQP B;  1BE3 A;  3AMJ B;  5CJO A;  3L71 B;  3L72 A;  1PPJ B;  3AMJ A;  2G54 A;  1NTK B;  4RPU A;  3H1J B;  4DTT A;  1NU1 A;  3E4A A;  3L74 B;  3N56 A;  1NTK A;  2A06 A;  1KB9 B;  4D6T B;  2IBZ B;  4U3F B;  4RE9 A;  1HR8 A;  4XEA A;  1HR6 B;  1KB9 A;  3E4Z A;  4U3F A;  3OFI A;  1PP9 B;  5KLV B;  2YPU A;  3AMI A;  1BGY B;  4GS8 A;  3CX5 A;  1SQX B;  1PP9 A;  3N57 A;  4GSC A;  1BGY A;  3HGZ A;  3H1L A;  3H44 A;  1SQX A;  2JBU A;  1KYO B;  3H1K A;  4PES A;  3L75 A;  3TUV A;  3L72 B;  3GO9 A;  1KYO A;  1HR9 B;  4PF9 A;  2JG4 A;  2WK3 A;  1HR9 A;  4RPU B;  1NU1 B;  2WBY A;  2A06 B;  2G49 A;  1HR8 B;  4NGE D;  3L70 B;  4IFH A;  4PF7 A;  3CX5 B;  3H1I B;  1NTZ A;  3L70 A;  3IH6 A;  2FYU A;  3H1L B;  3H1I A;  4L3T B;  3CWB A;  3H1K B;  4GSF A;  2BCC B;  3L75 B;  3P7L A;  3P7O A;  1HR7 A;  4L3T A;  4LTE A;  4PFC A;  1L0L A;  1SQB B;  2BCC A;  1SQB A;  4QIA A;  1SQQ B;  1SQV A;  1BCC B;  1SQQ A;  3CXH A;  2G47 A;  1BCC A;  3TGU A;  3E50 A;  4NNZ A;  1NTZ B;  1Q2L A;  1L0N A;  2FYU B;  3GWB A;  3CWB B;  4M1C A;  5KLV A;  1EZV A;  1NTM B;  3D3Y A;  1P84 A;  1HR7 B;  3BCC A;  1L0L B;  1NTM A;  3L73 A;  3QZ2 A;  1SQP A;  3H1H B;  4DWK A;  3CWW A;  3HDI A;  3L71 A;  1SQV B;  1PPJ A;  3H1H A;  5EUF A;  2WC0 A;  3CXH B;  4IOF A;  3H1J A;  3L74 A;  3TGU B;  4D6T A;  2IBZ A;  2G56 A;  4PD4 B;  2G48 A;  1L0N B;  1HR6 A;  3IVL A;  4PD4 A;  4D6T O;  4NXO A;  1EZV B;  4NGE A; 
#chains in the Genus database with same CATH homology
 1P84 B;  3BCC B;  1BE3 B;  2FGE A;  3EOQ A;  3L73 B;  4RAL A;  1SQP B;  1BE3 A;  3AMJ B;  5CJO A;  3L71 B;  3L72 A;  1PPJ B;  3AMJ A;  2G54 A;  1NTK B;  4RPU A;  3H1J B;  4DTT A;  1NU1 A;  3E4A A;  3L74 B;  3N56 A;  1NTK A;  2A06 A;  1KB9 B;  4D6T B;  2IBZ B;  4U3F B;  4RE9 A;  1HR8 A;  4XEA A;  1HR6 B;  1KB9 A;  3E4Z A;  4U3F A;  3OFI A;  1PP9 B;  5KLV B;  2YPU A;  3AMI A;  1BGY B;  4GS8 A;  3CX5 A;  1SQX B;  1PP9 A;  3N57 A;  4GSC A;  1BGY A;  3HGZ A;  3H1L A;  3H44 A;  1SQX A;  2JBU A;  1KYO B;  3H1K A;  4PES A;  3L75 A;  3TUV A;  3L72 B;  3GO9 A;  1KYO A;  1HR9 B;  4PF9 A;  2JG4 A;  2WK3 A;  1HR9 A;  4RPU B;  1NU1 B;  2WBY A;  2A06 B;  2G49 A;  1HR8 B;  4NGE D;  3L70 B;  4IFH A;  4PF7 A;  3CX5 B;  3H1I B;  1NTZ A;  3L70 A;  3IH6 A;  2FYU A;  3H1L B;  3H1I A;  4L3T B;  3CWB A;  3H1K B;  4GSF A;  2BCC B;  3L75 B;  3P7L A;  3P7O A;  1HR7 A;  4L3T A;  4LTE A;  4PFC A;  1L0L A;  1SQB B;  2BCC A;  1SQB A;  4QIA A;  1SQQ B;  1SQV A;  1BCC B;  1SQQ A;  3CXH A;  2G47 A;  1BCC A;  3TGU A;  3E50 A;  4NNZ A;  1NTZ B;  1Q2L A;  1L0N A;  2FYU B;  3GWB A;  3CWB B;  4M1C A;  5KLV A;  1EZV A;  1NTM B;  3D3Y A;  1P84 A;  1HR7 B;  3BCC A;  1L0L B;  1NTM A;  3L73 A;  3QZ2 A;  1SQP A;  3H1H B;  4DWK A;  3CWW A;  3HDI A;  3L71 A;  1SQV B;  1PPJ A;  3H1H A;  5EUF A;  2WC0 A;  3CXH B;  4IOF A;  3H1J A;  3L74 A;  3TGU B;  4D6T A;  2IBZ A;  2G56 A;  4PD4 B;  2G48 A;  1L0N B;  1HR6 A;  3IVL A;  4PD4 A;  4D6T O;  4NXO A;  1EZV B;  4NGE A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite