3TUVA

Crystal structure of insulysin with bound atp
Total Genus 337
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
337
sequence length
970
structure length
961
Chain Sequence
MNNPAIQRIEDHIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILALEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQRRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Hydrolase
molecule keywords Insulin-degrading enzyme
publication title Anion Activation Site of Insulin-degrading Enzyme.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 337
structure length 961
sequence length 970
ec nomenclature ec 3.4.24.56: Insulysin.
pdb deposition date 2011-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00675 Peptidase_M16 Insulinase (Peptidase family M16)
A PF05193 Peptidase_M16_C Peptidase M16 inactive domain
A PF16187 Peptidase_M16_M Middle or third domain of peptidase_M16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3tuvA03
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3tuvA04
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3tuvA02
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3tuvA01
1NU1B 1SQVB 4PF9A 3L70A 3H1LB 3CWBA 1HR8A 2BCCB 4DWKA 4M1CA 1NTKA 1P84B 1SQPA 1HR6B 3AMJA 4L3TA 1BE3A 3CXHB 4RPUB 1SQXB 1SQBB 4PESA 3H1HA 3H1KB 3E50A 3L71B 2G48A 4U3FB 3CX5B 3L72A 1PP9A 1BGYB 3L70B 4PD4B 3GO9A 4D6TB 3CWBB 1HR8B 4QIAA 4DTTA 4NGED 1BCCA 1SQPB 3E4AA 3H1IA 4PFCA 2IBZA 3E4ZA 3L73A 3BCCA 1EZVB 2YPUA 3P7LA 1KB9A 3N56A 2WBYA 1HR9A 3AMIA 3L72B 2WK3A 1SQQB 4IOFA 4PF7A 5CJOA 3L74B 4D6TO 1BCCB 3H1IB 2IBZB 3IVLA 1PPJA 3QZ2A 4XEAA 3BCCB 2FGEA 1NTKB 2G47A 1KB9B 2WC0A 1HR9B 4GSCA 3AMJB 4L3TB 1BE3B 3EOQA 1NTMA 3HGZA 5EUFA 3H1HB 3H44A 4LTEA 1PP9B 3CWWA 3N57A 1Q2LA 3TUVA 1PPJB 1NTZA 1P84A 2G56A 4RE9A 3CXHA 5KLVA 1SQXA 2JG4A 2G54A 4GSFA 3H1JA 3L75A 1L0NA 4IFHA 3OFIA 1L0LA 3L71A 1NTMB 3L73B 3CX5A 2A06A 1KYOA 3HDIA 1BGYA 4PD4A 3TGUA 4D6TA 1HR7A 3GWBA 3IH6A 2G49A 2FYUA 1NTZB 4RALA 1NU1A 1SQVA 4NXOA 3D3YA 5KLVB 3H1LA 2BCCA 4GS8A 3H1JB 3L75B 1EZVA 1L0NB 1L0LB 3P7OA 2JBUA 4NNZA 2A06B 1KYOB 1HR6A 4RPUA 3TGUB 1HR7B 1SQBA 1SQQA 2FYUB 3H1KA 4NGEA 3L74A 4U3FA
chains in the Genus database with same CATH superfamily
1NU1B 1SQVB 4PF9A 3L70A 3H1LB 3CWBA 1HR8A 2BCCB 4DWKA 4M1CA 1NTKA 1P84B 1SQPA 1HR6B 3AMJA 4L3TA 1BE3A 3CXHB 4RPUB 1SQXB 1SQBB 4PESA 3H1HA 3H1KB 3E50A 3L71B 2G48A 4U3FB 3CX5B 3L72A 1PP9A 1BGYB 3L70B 4PD4B 3GO9A 4D6TB 3CWBB 1HR8B 4QIAA 4DTTA 4NGED 1BCCA 1SQPB 3E4AA 3H1IA 4PFCA 2IBZA 3E4ZA 3L73A 3BCCA 1EZVB 2YPUA 3P7LA 1KB9A 3N56A 2WBYA 1HR9A 3AMIA 3L72B 2WK3A 1SQQB 4IOFA 4PF7A 5CJOA 3L74B 4D6TO 1BCCB 3H1IB 2IBZB 3IVLA 1PPJA 3QZ2A 4XEAA 3BCCB 2FGEA 1NTKB 2G47A 1KB9B 2WC0A 1HR9B 4GSCA 3AMJB 4L3TB 1BE3B 3EOQA 1NTMA 3HGZA 5EUFA 3H1HB 3H44A 4LTEA 1PP9B 3CWWA 3N57A 1Q2LA 3TUVA 1PPJB 1NTZA 1P84A 2G56A 4RE9A 3CXHA 5KLVA 1SQXA 2JG4A 2G54A 4GSFA 3H1JA 3L75A 1L0NA 4IFHA 3OFIA 1L0LA 3L71A 1NTMB 3L73B 3CX5A 2A06A 1KYOA 3HDIA 1BGYA 4PD4A 3TGUA 4D6TA 1HR7A 3GWBA 3IH6A 2G49A 2FYUA 1NTZB 4RALA 1NU1A 1SQVA 4NXOA 3D3YA 5KLVB 3H1LA 2BCCA 4GS8A 3H1JB 3L75B 1EZVA 1L0NB 1L0LB 3P7OA 2JBUA 4NNZA 2A06B 1KYOB 1HR6A 4RPUA 3TGUB 1HR7B 1SQBA 1SQQA 2FYUB 3H1KA 4NGEA 3L74A 4U3FA
chains in the Genus database with same CATH topology
1NU1B 1SQVB 4PF9A 3L70A 3H1LB 3CWBA 1HR8A 2BCCB 4DWKA 4M1CA 1NTKA 1P84B 1SQPA 1HR6B 3AMJA 4L3TA 1BE3A 3CXHB 4RPUB 1SQXB 1SQBB 4PESA 3H1HA 3H1KB 3E50A 3L71B 2G48A 4U3FB 3CX5B 3L72A 1PP9A 1BGYB 3L70B 4PD4B 3GO9A 4D6TB 3CWBB 1HR8B 4QIAA 4DTTA 4NGED 1BCCA 1SQPB 3E4AA 3H1IA 4PFCA 2IBZA 3E4ZA 3L73A 3BCCA 1EZVB 2YPUA 3P7LA 1KB9A 3N56A 2WBYA 1HR9A 3AMIA 3L72B 2WK3A 1SQQB 4IOFA 4PF7A 5CJOA 3L74B 4D6TO 1BCCB 3H1IB 2IBZB 3IVLA 1PPJA 3QZ2A 4XEAA 3BCCB 2FGEA 1NTKB 2G47A 1KB9B 2WC0A 1HR9B 4GSCA 3AMJB 4L3TB 1BE3B 3EOQA 1NTMA 3HGZA 5EUFA 3H1HB 3H44A 4LTEA 1PP9B 3CWWA 3N57A 1Q2LA 3TUVA 1PPJB 1NTZA 1P84A 2G56A 4RE9A 3CXHA 5KLVA 1SQXA 2JG4A 2G54A 4GSFA 3H1JA 3L75A 1L0NA 4IFHA 3OFIA 1L0LA 3L71A 1NTMB 3L73B 3CX5A 2A06A 1KYOA 3HDIA 1BGYA 4PD4A 3TGUA 4D6TA 1HR7A 3GWBA 3IH6A 2G49A 2FYUA 1NTZB 4RALA 1NU1A 1SQVA 4NXOA 3D3YA 5KLVB 3H1LA 2BCCA 4GS8A 3H1JB 3L75B 1EZVA 1L0NB 1L0LB 3P7OA 2JBUA 4NNZA 2A06B 1KYOB 1HR6A 4RPUA 3TGUB 1HR7B 1SQBA 1SQQA 2FYUB 3H1KA 4NGEA 3L74A 4U3FA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1NU1 B;  1SQV B;  4PF9 A;  3L70 A;  3H1L B;  3CWB A;  1HR8 A;  2BCC B;  4DWK A;  4M1C A;  1NTK A;  1P84 B;  1SQP A;  1HR6 B;  3AMJ A;  4L3T A;  1BE3 A;  3CXH B;  4RPU B;  1SQX B;  1SQB B;  4PES A;  3H1H A;  3H1K B;  3E50 A;  3L71 B;  2G48 A;  4U3F B;  3CX5 B;  3L72 A;  1PP9 A;  1BGY B;  3L70 B;  4PD4 B;  3GO9 A;  4D6T B;  3CWB B;  1HR8 B;  4QIA A;  4DTT A;  4NGE D;  1BCC A;  1SQP B;  3E4A A;  3H1I A;  4PFC A;  2IBZ A;  3E4Z A;  3L73 A;  3BCC A;  1EZV B;  2YPU A;  3P7L A;  1KB9 A;  3N56 A;  2WBY A;  1HR9 A;  3AMI A;  3L72 B;  2WK3 A;  1SQQ B;  4IOF A;  4PF7 A;  5CJO A;  3L74 B;  4D6T O;  1BCC B;  3H1I B;  2IBZ B;  3IVL A;  1PPJ A;  3QZ2 A;  4XEA A;  3BCC B;  2FGE A;  1NTK B;  2G47 A;  1KB9 B;  2WC0 A;  1HR9 B;  4GSC A;  3AMJ B;  4L3T B;  1BE3 B;  3EOQ A;  1NTM A;  3HGZ A;  5EUF A;  3H1H B;  3H44 A;  4LTE A;  1PP9 B;  3CWW A;  3N57 A;  1Q2L A;  3TUV A;  1PPJ B;  1NTZ A;  1P84 A;  2G56 A;  4RE9 A;  3CXH A;  5KLV A;  1SQX A;  2JG4 A;  2G54 A;  4GSF A;  3H1J A;  3L75 A;  1L0N A;  4IFH A;  3OFI A;  1L0L A;  3L71 A;  1NTM B;  3L73 B;  3CX5 A;  2A06 A;  1KYO A;  3HDI A;  1BGY A;  4PD4 A;  3TGU A;  4D6T A;  1HR7 A;  3GWB A;  3IH6 A;  2G49 A;  2FYU A;  1NTZ B;  4RAL A;  1NU1 A;  1SQV A;  4NXO A;  3D3Y A;  5KLV B;  3H1L A;  2BCC A;  4GS8 A;  3H1J B;  3L75 B;  1EZV A;  1L0N B;  1L0L B;  3P7O A;  2JBU A;  4NNZ A;  2A06 B;  1KYO B;  1HR6 A;  4RPU A;  3TGU B;  1HR7 B;  1SQB A;  1SQQ A;  2FYU B;  3H1K A;  4NGE A;  3L74 A;  4U3F A; 
#chains in the Genus database with same CATH topology
 1NU1 B;  1SQV B;  4PF9 A;  3L70 A;  3H1L B;  3CWB A;  1HR8 A;  2BCC B;  4DWK A;  4M1C A;  1NTK A;  1P84 B;  1SQP A;  1HR6 B;  3AMJ A;  4L3T A;  1BE3 A;  3CXH B;  4RPU B;  1SQX B;  1SQB B;  4PES A;  3H1H A;  3H1K B;  3E50 A;  3L71 B;  2G48 A;  4U3F B;  3CX5 B;  3L72 A;  1PP9 A;  1BGY B;  3L70 B;  4PD4 B;  3GO9 A;  4D6T B;  3CWB B;  1HR8 B;  4QIA A;  4DTT A;  4NGE D;  1BCC A;  1SQP B;  3E4A A;  3H1I A;  4PFC A;  2IBZ A;  3E4Z A;  3L73 A;  3BCC A;  1EZV B;  2YPU A;  3P7L A;  1KB9 A;  3N56 A;  2WBY A;  1HR9 A;  3AMI A;  3L72 B;  2WK3 A;  1SQQ B;  4IOF A;  4PF7 A;  5CJO A;  3L74 B;  4D6T O;  1BCC B;  3H1I B;  2IBZ B;  3IVL A;  1PPJ A;  3QZ2 A;  4XEA A;  3BCC B;  2FGE A;  1NTK B;  2G47 A;  1KB9 B;  2WC0 A;  1HR9 B;  4GSC A;  3AMJ B;  4L3T B;  1BE3 B;  3EOQ A;  1NTM A;  3HGZ A;  5EUF A;  3H1H B;  3H44 A;  4LTE A;  1PP9 B;  3CWW A;  3N57 A;  1Q2L A;  3TUV A;  1PPJ B;  1NTZ A;  1P84 A;  2G56 A;  4RE9 A;  3CXH A;  5KLV A;  1SQX A;  2JG4 A;  2G54 A;  4GSF A;  3H1J A;  3L75 A;  1L0N A;  4IFH A;  3OFI A;  1L0L A;  3L71 A;  1NTM B;  3L73 B;  3CX5 A;  2A06 A;  1KYO A;  3HDI A;  1BGY A;  4PD4 A;  3TGU A;  4D6T A;  1HR7 A;  3GWB A;  3IH6 A;  2G49 A;  2FYU A;  1NTZ B;  4RAL A;  1NU1 A;  1SQV A;  4NXO A;  3D3Y A;  5KLV B;  3H1L A;  2BCC A;  4GS8 A;  3H1J B;  3L75 B;  1EZV A;  1L0N B;  1L0L B;  3P7O A;  2JBU A;  4NNZ A;  2A06 B;  1KYO B;  1HR6 A;  4RPU A;  3TGU B;  1HR7 B;  1SQB A;  1SQQ A;  2FYU B;  3H1K A;  4NGE A;  3L74 A;  4U3F A; 
#chains in the Genus database with same CATH homology
 1NU1 B;  1SQV B;  4PF9 A;  3L70 A;  3H1L B;  3CWB A;  1HR8 A;  2BCC B;  4DWK A;  4M1C A;  1NTK A;  1P84 B;  1SQP A;  1HR6 B;  3AMJ A;  4L3T A;  1BE3 A;  3CXH B;  4RPU B;  1SQX B;  1SQB B;  4PES A;  3H1H A;  3H1K B;  3E50 A;  3L71 B;  2G48 A;  4U3F B;  3CX5 B;  3L72 A;  1PP9 A;  1BGY B;  3L70 B;  4PD4 B;  3GO9 A;  4D6T B;  3CWB B;  1HR8 B;  4QIA A;  4DTT A;  4NGE D;  1BCC A;  1SQP B;  3E4A A;  3H1I A;  4PFC A;  2IBZ A;  3E4Z A;  3L73 A;  3BCC A;  1EZV B;  2YPU A;  3P7L A;  1KB9 A;  3N56 A;  2WBY A;  1HR9 A;  3AMI A;  3L72 B;  2WK3 A;  1SQQ B;  4IOF A;  4PF7 A;  5CJO A;  3L74 B;  4D6T O;  1BCC B;  3H1I B;  2IBZ B;  3IVL A;  1PPJ A;  3QZ2 A;  4XEA A;  3BCC B;  2FGE A;  1NTK B;  2G47 A;  1KB9 B;  2WC0 A;  1HR9 B;  4GSC A;  3AMJ B;  4L3T B;  1BE3 B;  3EOQ A;  1NTM A;  3HGZ A;  5EUF A;  3H1H B;  3H44 A;  4LTE A;  1PP9 B;  3CWW A;  3N57 A;  1Q2L A;  3TUV A;  1PPJ B;  1NTZ A;  1P84 A;  2G56 A;  4RE9 A;  3CXH A;  5KLV A;  1SQX A;  2JG4 A;  2G54 A;  4GSF A;  3H1J A;  3L75 A;  1L0N A;  4IFH A;  3OFI A;  1L0L A;  3L71 A;  1NTM B;  3L73 B;  3CX5 A;  2A06 A;  1KYO A;  3HDI A;  1BGY A;  4PD4 A;  3TGU A;  4D6T A;  1HR7 A;  3GWB A;  3IH6 A;  2G49 A;  2FYU A;  1NTZ B;  4RAL A;  1NU1 A;  1SQV A;  4NXO A;  3D3Y A;  5KLV B;  3H1L A;  2BCC A;  4GS8 A;  3H1J B;  3L75 B;  1EZV A;  1L0N B;  1L0L B;  3P7O A;  2JBU A;  4NNZ A;  2A06 B;  1KYO B;  1HR6 A;  4RPU A;  3TGU B;  1HR7 B;  1SQB A;  1SQQ A;  2FYU B;  3H1K A;  4NGE A;  3L74 A;  4U3F A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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