4RPUB

Crystal structure of human presequence protease in complex with inhibitor mitoblock-60
Total Genus 305
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
305
sequence length
1006
structure length
940
Chain Sequence
AACERALQYLGDKIHGFTVNQVTSVPELFLTAVLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILQHTVLGSQYPCRDPFFMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLQIHEEALSFQIEPSTVVPAQTPWDKPREFQITCGPDSFSQTTVSVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIVEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLLGNQLAKFRQCLQENPKFLQEVQYFNNQHLTLSMRPDDKYHEQAQVEATKLKQVEALSPGDRQQIYEGLELRSQQSPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTLGCGLLDYREQAQQIELTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMRIAEMTDIPILRLPRIKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSPVRTVEKPVIRKLVMEPTFKPWQMTHFLMPFPVNYVGECIRTVPYTDPDHASLILARLMTAKFLHTEIREGGAYGGGALSHNGIFTLYSYRDPNTIETLQSFGAVDWASGFTQQDIDEALSVFSTVDAPVAPSDGMDHFLYGLSDEMQAHREQLFAVSHDLLAVSDRYLGTGSTHGLAILGPENPKIAKDPSWIIR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Presequence protease, mitochondrial
publication title Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60
rcsb
source organism Homo sapiens
total genus 305
structure length 940
sequence length 1006
ec nomenclature ec 3.4.24.-:
pdb deposition date 2014-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00675 Peptidase_M16 Insulinase (Peptidase family M16)
B PF05193 Peptidase_M16_C Peptidase M16 inactive domain
B PF08367 M16C_assoc Peptidase M16C associated
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 4rpuB02
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 4rpuB03
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 4rpuB01
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 4rpuB04
3P7OA 3TUVA 3L73A 2FGEA 3E4AA 4L3TA 1NU1A 2JG4A 3CX5A 1Q2LA 2G56A 3N57A 2FYUB 1HR6B 1KB9A 1HR7B 3H1HB 3E50A 2FYUA 3AMJB 3IH6A 1L0LB 1P84A 1BGYA 1SQXA 1KYOA 1HR7A 1SQQA 4RALA 3CWWA 2BCCA 1HR9A 3EOQA 3AMJA 2YPUA 2JBUA 4PF7A 1NTKB 2G49A 1SQPA 4GSCA 5CJOA 2IBZB 4IOFA 1L0NB 3E4ZA 3H1JB 4IFHA 3GO9A 4M1CA 5EUFA 4PESA 1EZVB 2IBZA 3GWBA 3CWBB 1SQBB 3L72B 1HR6A 3L75B 3AMIA 3L74B 3H1HA 4LTEA 2G47A 4RPUB 1SQBA 3HDIA 3H1LB 1HR8B 4QIAA 1L0LA 4D6TB 2G54A 4XEAA 3CXHB 4NNZA 3TGUB 1BCCB 4RPUA 4DWKA 3H1LA 2WBYA 2WK3A 4NXOA 4D6TA 3HGZA 1NTKA 1SQVB 3H1KB 3IVLA 4U3FB 1NTZB 4DTTA 4RE9A 1L0NA 3H1IB 3H1JA 1BE3B 3D3YA 3H1KA 4L3TB 1NU1B 1EZVA 1NTZA 4U3FA 3CWBA 3N56A 3OFIA 5KLVB 3L72A 3L71B 1KB9B 3L75A 3L74A 4NGED 2G48A 4PD4B 1NTMB 4GSFA 5KLVA 1P84B 1PP9B 2WC0A 3L71A 1HR8A 1BGYB 1SQXB 1KYOB 4GS8A 1SQQB 3CXHA 2BCCB 1HR9B 4NGEA 3TGUA 4PD4A 1NTMA 4PF9A 1BCCA 4PFCA 1PP9A 3BCCB 1PPJB 3L70B 2A06B 3QZ2A 1SQPB 3L73B 1SQVA 3P7LA 3H44A 4D6TO 3CX5B 3BCCA 1PPJA 3H1IA 3L70A 1BE3A 2A06A
chains in the Genus database with same CATH superfamily
3P7OA 3TUVA 3L73A 2FGEA 3E4AA 4L3TA 1NU1A 2JG4A 3CX5A 1Q2LA 2G56A 3N57A 2FYUB 1HR6B 1KB9A 1HR7B 3H1HB 3E50A 2FYUA 3AMJB 3IH6A 1L0LB 1P84A 1BGYA 1SQXA 1KYOA 1HR7A 1SQQA 4RALA 3CWWA 2BCCA 1HR9A 3EOQA 3AMJA 2YPUA 2JBUA 4PF7A 1NTKB 2G49A 1SQPA 4GSCA 5CJOA 2IBZB 4IOFA 1L0NB 3E4ZA 3H1JB 4IFHA 3GO9A 4M1CA 5EUFA 4PESA 1EZVB 2IBZA 3GWBA 3CWBB 1SQBB 3L72B 1HR6A 3L75B 3AMIA 3L74B 3H1HA 4LTEA 2G47A 4RPUB 1SQBA 3HDIA 3H1LB 1HR8B 4QIAA 1L0LA 4D6TB 2G54A 4XEAA 3CXHB 4NNZA 3TGUB 1BCCB 4RPUA 4DWKA 3H1LA 2WBYA 2WK3A 4NXOA 4D6TA 3HGZA 1NTKA 1SQVB 3H1KB 3IVLA 4U3FB 1NTZB 4DTTA 4RE9A 1L0NA 3H1IB 3H1JA 1BE3B 3D3YA 3H1KA 4L3TB 1NU1B 1EZVA 1NTZA 4U3FA 3CWBA 3N56A 3OFIA 5KLVB 3L72A 3L71B 1KB9B 3L75A 3L74A 4NGED 2G48A 4PD4B 1NTMB 4GSFA 5KLVA 1P84B 1PP9B 2WC0A 3L71A 1HR8A 1BGYB 1SQXB 1KYOB 4GS8A 1SQQB 3CXHA 2BCCB 1HR9B 4NGEA 3TGUA 4PD4A 1NTMA 4PF9A 1BCCA 4PFCA 1PP9A 3BCCB 1PPJB 3L70B 2A06B 3QZ2A 1SQPB 3L73B 1SQVA 3P7LA 3H44A 4D6TO 3CX5B 3BCCA 1PPJA 3H1IA 3L70A 1BE3A 2A06A
chains in the Genus database with same CATH topology
3P7OA 3TUVA 3L73A 2FGEA 3E4AA 4L3TA 1NU1A 2JG4A 3CX5A 1Q2LA 2G56A 3N57A 2FYUB 1HR6B 1KB9A 1HR7B 3H1HB 3E50A 2FYUA 3AMJB 3IH6A 1L0LB 1P84A 1BGYA 1SQXA 1KYOA 1HR7A 1SQQA 4RALA 3CWWA 2BCCA 1HR9A 3EOQA 3AMJA 2YPUA 2JBUA 4PF7A 1NTKB 2G49A 1SQPA 4GSCA 5CJOA 2IBZB 4IOFA 1L0NB 3E4ZA 3H1JB 4IFHA 3GO9A 4M1CA 5EUFA 4PESA 1EZVB 2IBZA 3GWBA 3CWBB 1SQBB 3L72B 1HR6A 3L75B 3AMIA 3L74B 3H1HA 4LTEA 2G47A 4RPUB 1SQBA 3HDIA 3H1LB 1HR8B 4QIAA 1L0LA 4D6TB 2G54A 4XEAA 3CXHB 4NNZA 3TGUB 1BCCB 4RPUA 4DWKA 3H1LA 2WBYA 2WK3A 4NXOA 4D6TA 3HGZA 1NTKA 1SQVB 3H1KB 3IVLA 4U3FB 1NTZB 4DTTA 4RE9A 1L0NA 3H1IB 3H1JA 1BE3B 3D3YA 3H1KA 4L3TB 1NU1B 1EZVA 1NTZA 4U3FA 3CWBA 3N56A 3OFIA 5KLVB 3L72A 3L71B 1KB9B 3L75A 3L74A 4NGED 2G48A 4PD4B 1NTMB 4GSFA 5KLVA 1P84B 1PP9B 2WC0A 3L71A 1HR8A 1BGYB 1SQXB 1KYOB 4GS8A 1SQQB 3CXHA 2BCCB 1HR9B 4NGEA 3TGUA 4PD4A 1NTMA 4PF9A 1BCCA 4PFCA 1PP9A 3BCCB 1PPJB 3L70B 2A06B 3QZ2A 1SQPB 3L73B 1SQVA 3P7LA 3H44A 4D6TO 3CX5B 3BCCA 1PPJA 3H1IA 3L70A 1BE3A 2A06A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3P7O A;  3TUV A;  3L73 A;  2FGE A;  3E4A A;  4L3T A;  1NU1 A;  2JG4 A;  3CX5 A;  1Q2L A;  2G56 A;  3N57 A;  2FYU B;  1HR6 B;  1KB9 A;  1HR7 B;  3H1H B;  3E50 A;  2FYU A;  3AMJ B;  3IH6 A;  1L0L B;  1P84 A;  1BGY A;  1SQX A;  1KYO A;  1HR7 A;  1SQQ A;  4RAL A;  3CWW A;  2BCC A;  1HR9 A;  3EOQ A;  3AMJ A;  2YPU A;  2JBU A;  4PF7 A;  1NTK B;  2G49 A;  1SQP A;  4GSC A;  5CJO A;  2IBZ B;  4IOF A;  1L0N B;  3E4Z A;  3H1J B;  4IFH A;  3GO9 A;  4M1C A;  5EUF A;  4PES A;  1EZV B;  2IBZ A;  3GWB A;  3CWB B;  1SQB B;  3L72 B;  1HR6 A;  3L75 B;  3AMI A;  3L74 B;  3H1H A;  4LTE A;  2G47 A;  4RPU B;  1SQB A;  3HDI A;  3H1L B;  1HR8 B;  4QIA A;  1L0L A;  4D6T B;  2G54 A;  4XEA A;  3CXH B;  4NNZ A;  3TGU B;  1BCC B;  4RPU A;  4DWK A;  3H1L A;  2WBY A;  2WK3 A;  4NXO A;  4D6T A;  3HGZ A;  1NTK A;  1SQV B;  3H1K B;  3IVL A;  4U3F B;  1NTZ B;  4DTT A;  4RE9 A;  1L0N A;  3H1I B;  3H1J A;  1BE3 B;  3D3Y A;  3H1K A;  4L3T B;  1NU1 B;  1EZV A;  1NTZ A;  4U3F A;  3CWB A;  3N56 A;  3OFI A;  5KLV B;  3L72 A;  3L71 B;  1KB9 B;  3L75 A;  3L74 A;  4NGE D;  2G48 A;  4PD4 B;  1NTM B;  4GSF A;  5KLV A;  1P84 B;  1PP9 B;  2WC0 A;  3L71 A;  1HR8 A;  1BGY B;  1SQX B;  1KYO B;  4GS8 A;  1SQQ B;  3CXH A;  2BCC B;  1HR9 B;  4NGE A;  3TGU A;  4PD4 A;  1NTM A;  4PF9 A;  1BCC A;  4PFC A;  1PP9 A;  3BCC B;  1PPJ B;  3L70 B;  2A06 B;  3QZ2 A;  1SQP B;  3L73 B;  1SQV A;  3P7L A;  3H44 A;  4D6T O;  3CX5 B;  3BCC A;  1PPJ A;  3H1I A;  3L70 A;  1BE3 A;  2A06 A; 
#chains in the Genus database with same CATH topology
 3P7O A;  3TUV A;  3L73 A;  2FGE A;  3E4A A;  4L3T A;  1NU1 A;  2JG4 A;  3CX5 A;  1Q2L A;  2G56 A;  3N57 A;  2FYU B;  1HR6 B;  1KB9 A;  1HR7 B;  3H1H B;  3E50 A;  2FYU A;  3AMJ B;  3IH6 A;  1L0L B;  1P84 A;  1BGY A;  1SQX A;  1KYO A;  1HR7 A;  1SQQ A;  4RAL A;  3CWW A;  2BCC A;  1HR9 A;  3EOQ A;  3AMJ A;  2YPU A;  2JBU A;  4PF7 A;  1NTK B;  2G49 A;  1SQP A;  4GSC A;  5CJO A;  2IBZ B;  4IOF A;  1L0N B;  3E4Z A;  3H1J B;  4IFH A;  3GO9 A;  4M1C A;  5EUF A;  4PES A;  1EZV B;  2IBZ A;  3GWB A;  3CWB B;  1SQB B;  3L72 B;  1HR6 A;  3L75 B;  3AMI A;  3L74 B;  3H1H A;  4LTE A;  2G47 A;  4RPU B;  1SQB A;  3HDI A;  3H1L B;  1HR8 B;  4QIA A;  1L0L A;  4D6T B;  2G54 A;  4XEA A;  3CXH B;  4NNZ A;  3TGU B;  1BCC B;  4RPU A;  4DWK A;  3H1L A;  2WBY A;  2WK3 A;  4NXO A;  4D6T A;  3HGZ A;  1NTK A;  1SQV B;  3H1K B;  3IVL A;  4U3F B;  1NTZ B;  4DTT A;  4RE9 A;  1L0N A;  3H1I B;  3H1J A;  1BE3 B;  3D3Y A;  3H1K A;  4L3T B;  1NU1 B;  1EZV A;  1NTZ A;  4U3F A;  3CWB A;  3N56 A;  3OFI A;  5KLV B;  3L72 A;  3L71 B;  1KB9 B;  3L75 A;  3L74 A;  4NGE D;  2G48 A;  4PD4 B;  1NTM B;  4GSF A;  5KLV A;  1P84 B;  1PP9 B;  2WC0 A;  3L71 A;  1HR8 A;  1BGY B;  1SQX B;  1KYO B;  4GS8 A;  1SQQ B;  3CXH A;  2BCC B;  1HR9 B;  4NGE A;  3TGU A;  4PD4 A;  1NTM A;  4PF9 A;  1BCC A;  4PFC A;  1PP9 A;  3BCC B;  1PPJ B;  3L70 B;  2A06 B;  3QZ2 A;  1SQP B;  3L73 B;  1SQV A;  3P7L A;  3H44 A;  4D6T O;  3CX5 B;  3BCC A;  1PPJ A;  3H1I A;  3L70 A;  1BE3 A;  2A06 A; 
#chains in the Genus database with same CATH homology
 3P7O A;  3TUV A;  3L73 A;  2FGE A;  3E4A A;  4L3T A;  1NU1 A;  2JG4 A;  3CX5 A;  1Q2L A;  2G56 A;  3N57 A;  2FYU B;  1HR6 B;  1KB9 A;  1HR7 B;  3H1H B;  3E50 A;  2FYU A;  3AMJ B;  3IH6 A;  1L0L B;  1P84 A;  1BGY A;  1SQX A;  1KYO A;  1HR7 A;  1SQQ A;  4RAL A;  3CWW A;  2BCC A;  1HR9 A;  3EOQ A;  3AMJ A;  2YPU A;  2JBU A;  4PF7 A;  1NTK B;  2G49 A;  1SQP A;  4GSC A;  5CJO A;  2IBZ B;  4IOF A;  1L0N B;  3E4Z A;  3H1J B;  4IFH A;  3GO9 A;  4M1C A;  5EUF A;  4PES A;  1EZV B;  2IBZ A;  3GWB A;  3CWB B;  1SQB B;  3L72 B;  1HR6 A;  3L75 B;  3AMI A;  3L74 B;  3H1H A;  4LTE A;  2G47 A;  4RPU B;  1SQB A;  3HDI A;  3H1L B;  1HR8 B;  4QIA A;  1L0L A;  4D6T B;  2G54 A;  4XEA A;  3CXH B;  4NNZ A;  3TGU B;  1BCC B;  4RPU A;  4DWK A;  3H1L A;  2WBY A;  2WK3 A;  4NXO A;  4D6T A;  3HGZ A;  1NTK A;  1SQV B;  3H1K B;  3IVL A;  4U3F B;  1NTZ B;  4DTT A;  4RE9 A;  1L0N A;  3H1I B;  3H1J A;  1BE3 B;  3D3Y A;  3H1K A;  4L3T B;  1NU1 B;  1EZV A;  1NTZ A;  4U3F A;  3CWB A;  3N56 A;  3OFI A;  5KLV B;  3L72 A;  3L71 B;  1KB9 B;  3L75 A;  3L74 A;  4NGE D;  2G48 A;  4PD4 B;  1NTM B;  4GSF A;  5KLV A;  1P84 B;  1PP9 B;  2WC0 A;  3L71 A;  1HR8 A;  1BGY B;  1SQX B;  1KYO B;  4GS8 A;  1SQQ B;  3CXH A;  2BCC B;  1HR9 B;  4NGE A;  3TGU A;  4PD4 A;  1NTM A;  4PF9 A;  1BCC A;  4PFC A;  1PP9 A;  3BCC B;  1PPJ B;  3L70 B;  2A06 B;  3QZ2 A;  1SQP B;  3L73 B;  1SQV A;  3P7L A;  3H44 A;  4D6T O;  3CX5 B;  3BCC A;  1PPJ A;  3H1I A;  3L70 A;  1BE3 A;  2A06 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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