3H44A

Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 alpha
Total Genus 338
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
338
sequence length
969
structure length
956
Chain Sequence
NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Hydrolase/cytokine
molecule keywords Insulin-degrading enzyme
publication title Macrophage Inflammatory Protein-1 Is A Novel High Affinity Substrate For Human Insulin Degrading Enzyme
rcsb
source organism Homo sapiens
total genus 338
structure length 956
sequence length 969
chains with identical sequence B
ec nomenclature ec 3.4.24.56: Insulysin.
pdb deposition date 2009-04-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00675 Peptidase_M16 Insulinase (Peptidase family M16)
A PF05193 Peptidase_M16_C Peptidase M16 inactive domain
A PF16187 Peptidase_M16_M Middle or third domain of peptidase_M16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3h44A03
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3h44A04
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3h44A02
3.30.830.10 Alpha Beta 2-Layer Sandwich Cytochrome Bc1 Complex; Chain A, domain 1 Metalloenzyme, LuxS/M16 peptidase-like 3h44A01
3OFIA 1BE3B 1BCCA 1SQVA 4PFCA 5EUFA 1NTMB 1SQPA 3CWBA 1KYOA 2IBZA 3GO9A 3P7OA 4DTTA 5KLVA 4D6TO 4GSFA 1SQBA 3L75B 3L71B 1HR9B 4PD4A 3TGUA 3H1HA 1HR8B 4NGED 2FYUB 3L73B 1PP9B 3H1IB 1NU1B 2G54A 1HR6B 3TUVA 3HGZA 4NGEA 1EZVA 4IFHA 3H1LA 3H1JA 2JBUA 3AMJA 2YPUA 1NTKA 3E4ZA 3L74B 4PF7A 2A06B 3CWWA 1PPJA 4L3TB 1HR7B 3QZ2A 4GSCA 2G47A 3L70A 3GWBA 4RPUB 4U3FB 4DWKA 4M1CA 4PESA 2JG4A 3L75A 3HDIA 1NTZB 1SQQA 3L71A 1HR9A 1L0NB 2FYUA 3L72A 1PP9A 1BCCB 3BCCB 1L0LA 3H1IA 2WBYA 1Q2LA 2G56A 4D6TA 4PF9A 2BCCA 1NU1A 4RE9A 1KB9B 1HR6A 3CWBB 4QIAA 1KYOB 3H1KB 5KLVB 2WC0A 1SQXA 3IVLA 3CXHB 1SQBB 1BGYA 4PD4B 3TGUB 2G48A 3P7LA 1BE3A 2A06A 1P84B 4GS8A 1HR7A 1NTMA 3CX5B 3N57A 4RALA 4RPUA 4U3FA 3H1LB 3AMJB 1HR8A 3L73A 3EOQA 1L0NA 1SQVB 1PPJB 3BCCA 1SQPB 5CJOA 2IBZB 4NNZA 3L70B 1KB9A 2FGEA 3D3YA 3H1KA 3CXHA 2WK3A 3E50A 3H1HB 3L74A 4XEAA 1SQQB 3AMIA 4NXOA 4L3TA 3L72B 4IOFA 1L0LB 3E4AA 1P84A 3H44A 4D6TB 1EZVB 2BCCB 3N56A 3CX5A 3H1JB 1NTKB 1SQXB 1NTZA 1BGYB 4LTEA 2G49A 3IH6A
chains in the Genus database with same CATH superfamily
3OFIA 1BE3B 1BCCA 1SQVA 4PFCA 5EUFA 1NTMB 1SQPA 3CWBA 1KYOA 2IBZA 3GO9A 3P7OA 4DTTA 5KLVA 4D6TO 4GSFA 1SQBA 3L75B 3L71B 1HR9B 4PD4A 3TGUA 3H1HA 1HR8B 4NGED 2FYUB 3L73B 1PP9B 3H1IB 1NU1B 2G54A 1HR6B 3TUVA 3HGZA 4NGEA 1EZVA 4IFHA 3H1LA 3H1JA 2JBUA 3AMJA 2YPUA 1NTKA 3E4ZA 3L74B 4PF7A 2A06B 3CWWA 1PPJA 4L3TB 1HR7B 3QZ2A 4GSCA 2G47A 3L70A 3GWBA 4RPUB 4U3FB 4DWKA 4M1CA 4PESA 2JG4A 3L75A 3HDIA 1NTZB 1SQQA 3L71A 1HR9A 1L0NB 2FYUA 3L72A 1PP9A 1BCCB 3BCCB 1L0LA 3H1IA 2WBYA 1Q2LA 2G56A 4D6TA 4PF9A 2BCCA 1NU1A 4RE9A 1KB9B 1HR6A 3CWBB 4QIAA 1KYOB 3H1KB 5KLVB 2WC0A 1SQXA 3IVLA 3CXHB 1SQBB 1BGYA 4PD4B 3TGUB 2G48A 3P7LA 1BE3A 2A06A 1P84B 4GS8A 1HR7A 1NTMA 3CX5B 3N57A 4RALA 4RPUA 4U3FA 3H1LB 3AMJB 1HR8A 3L73A 3EOQA 1L0NA 1SQVB 1PPJB 3BCCA 1SQPB 5CJOA 2IBZB 4NNZA 3L70B 1KB9A 2FGEA 3D3YA 3H1KA 3CXHA 2WK3A 3E50A 3H1HB 3L74A 4XEAA 1SQQB 3AMIA 4NXOA 4L3TA 3L72B 4IOFA 1L0LB 3E4AA 1P84A 3H44A 4D6TB 1EZVB 2BCCB 3N56A 3CX5A 3H1JB 1NTKB 1SQXB 1NTZA 1BGYB 4LTEA 2G49A 3IH6A
chains in the Genus database with same CATH topology
3OFIA 1BE3B 1BCCA 1SQVA 4PFCA 5EUFA 1NTMB 1SQPA 3CWBA 1KYOA 2IBZA 3GO9A 3P7OA 4DTTA 5KLVA 4D6TO 4GSFA 1SQBA 3L75B 3L71B 1HR9B 4PD4A 3TGUA 3H1HA 1HR8B 4NGED 2FYUB 3L73B 1PP9B 3H1IB 1NU1B 2G54A 1HR6B 3TUVA 3HGZA 4NGEA 1EZVA 4IFHA 3H1LA 3H1JA 2JBUA 3AMJA 2YPUA 1NTKA 3E4ZA 3L74B 4PF7A 2A06B 3CWWA 1PPJA 4L3TB 1HR7B 3QZ2A 4GSCA 2G47A 3L70A 3GWBA 4RPUB 4U3FB 4DWKA 4M1CA 4PESA 2JG4A 3L75A 3HDIA 1NTZB 1SQQA 3L71A 1HR9A 1L0NB 2FYUA 3L72A 1PP9A 1BCCB 3BCCB 1L0LA 3H1IA 2WBYA 1Q2LA 2G56A 4D6TA 4PF9A 2BCCA 1NU1A 4RE9A 1KB9B 1HR6A 3CWBB 4QIAA 1KYOB 3H1KB 5KLVB 2WC0A 1SQXA 3IVLA 3CXHB 1SQBB 1BGYA 4PD4B 3TGUB 2G48A 3P7LA 1BE3A 2A06A 1P84B 4GS8A 1HR7A 1NTMA 3CX5B 3N57A 4RALA 4RPUA 4U3FA 3H1LB 3AMJB 1HR8A 3L73A 3EOQA 1L0NA 1SQVB 1PPJB 3BCCA 1SQPB 5CJOA 2IBZB 4NNZA 3L70B 1KB9A 2FGEA 3D3YA 3H1KA 3CXHA 2WK3A 3E50A 3H1HB 3L74A 4XEAA 1SQQB 3AMIA 4NXOA 4L3TA 3L72B 4IOFA 1L0LB 3E4AA 1P84A 3H44A 4D6TB 1EZVB 2BCCB 3N56A 3CX5A 3H1JB 1NTKB 1SQXB 1NTZA 1BGYB 4LTEA 2G49A 3IH6A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3OFI A;  1BE3 B;  1BCC A;  1SQV A;  4PFC A;  5EUF A;  1NTM B;  1SQP A;  3CWB A;  1KYO A;  2IBZ A;  3GO9 A;  3P7O A;  4DTT A;  5KLV A;  4D6T O;  4GSF A;  1SQB A;  3L75 B;  3L71 B;  1HR9 B;  4PD4 A;  3TGU A;  3H1H A;  1HR8 B;  4NGE D;  2FYU B;  3L73 B;  1PP9 B;  3H1I B;  1NU1 B;  2G54 A;  1HR6 B;  3TUV A;  3HGZ A;  4NGE A;  1EZV A;  4IFH A;  3H1L A;  3H1J A;  2JBU A;  3AMJ A;  2YPU A;  1NTK A;  3E4Z A;  3L74 B;  4PF7 A;  2A06 B;  3CWW A;  1PPJ A;  4L3T B;  1HR7 B;  3QZ2 A;  4GSC A;  2G47 A;  3L70 A;  3GWB A;  4RPU B;  4U3F B;  4DWK A;  4M1C A;  4PES A;  2JG4 A;  3L75 A;  3HDI A;  1NTZ B;  1SQQ A;  3L71 A;  1HR9 A;  1L0N B;  2FYU A;  3L72 A;  1PP9 A;  1BCC B;  3BCC B;  1L0L A;  3H1I A;  2WBY A;  1Q2L A;  2G56 A;  4D6T A;  4PF9 A;  2BCC A;  1NU1 A;  4RE9 A;  1KB9 B;  1HR6 A;  3CWB B;  4QIA A;  1KYO B;  3H1K B;  5KLV B;  2WC0 A;  1SQX A;  3IVL A;  3CXH B;  1SQB B;  1BGY A;  4PD4 B;  3TGU B;  2G48 A;  3P7L A;  1BE3 A;  2A06 A;  1P84 B;  4GS8 A;  1HR7 A;  1NTM A;  3CX5 B;  3N57 A;  4RAL A;  4RPU A;  4U3F A;  3H1L B;  3AMJ B;  1HR8 A;  3L73 A;  3EOQ A;  1L0N A;  1SQV B;  1PPJ B;  3BCC A;  1SQP B;  5CJO A;  2IBZ B;  4NNZ A;  3L70 B;  1KB9 A;  2FGE A;  3D3Y A;  3H1K A;  3CXH A;  2WK3 A;  3E50 A;  3H1H B;  3L74 A;  4XEA A;  1SQQ B;  3AMI A;  4NXO A;  4L3T A;  3L72 B;  4IOF A;  1L0L B;  3E4A A;  1P84 A;  3H44 A;  4D6T B;  1EZV B;  2BCC B;  3N56 A;  3CX5 A;  3H1J B;  1NTK B;  1SQX B;  1NTZ A;  1BGY B;  4LTE A;  2G49 A;  3IH6 A; 
#chains in the Genus database with same CATH topology
 3OFI A;  1BE3 B;  1BCC A;  1SQV A;  4PFC A;  5EUF A;  1NTM B;  1SQP A;  3CWB A;  1KYO A;  2IBZ A;  3GO9 A;  3P7O A;  4DTT A;  5KLV A;  4D6T O;  4GSF A;  1SQB A;  3L75 B;  3L71 B;  1HR9 B;  4PD4 A;  3TGU A;  3H1H A;  1HR8 B;  4NGE D;  2FYU B;  3L73 B;  1PP9 B;  3H1I B;  1NU1 B;  2G54 A;  1HR6 B;  3TUV A;  3HGZ A;  4NGE A;  1EZV A;  4IFH A;  3H1L A;  3H1J A;  2JBU A;  3AMJ A;  2YPU A;  1NTK A;  3E4Z A;  3L74 B;  4PF7 A;  2A06 B;  3CWW A;  1PPJ A;  4L3T B;  1HR7 B;  3QZ2 A;  4GSC A;  2G47 A;  3L70 A;  3GWB A;  4RPU B;  4U3F B;  4DWK A;  4M1C A;  4PES A;  2JG4 A;  3L75 A;  3HDI A;  1NTZ B;  1SQQ A;  3L71 A;  1HR9 A;  1L0N B;  2FYU A;  3L72 A;  1PP9 A;  1BCC B;  3BCC B;  1L0L A;  3H1I A;  2WBY A;  1Q2L A;  2G56 A;  4D6T A;  4PF9 A;  2BCC A;  1NU1 A;  4RE9 A;  1KB9 B;  1HR6 A;  3CWB B;  4QIA A;  1KYO B;  3H1K B;  5KLV B;  2WC0 A;  1SQX A;  3IVL A;  3CXH B;  1SQB B;  1BGY A;  4PD4 B;  3TGU B;  2G48 A;  3P7L A;  1BE3 A;  2A06 A;  1P84 B;  4GS8 A;  1HR7 A;  1NTM A;  3CX5 B;  3N57 A;  4RAL A;  4RPU A;  4U3F A;  3H1L B;  3AMJ B;  1HR8 A;  3L73 A;  3EOQ A;  1L0N A;  1SQV B;  1PPJ B;  3BCC A;  1SQP B;  5CJO A;  2IBZ B;  4NNZ A;  3L70 B;  1KB9 A;  2FGE A;  3D3Y A;  3H1K A;  3CXH A;  2WK3 A;  3E50 A;  3H1H B;  3L74 A;  4XEA A;  1SQQ B;  3AMI A;  4NXO A;  4L3T A;  3L72 B;  4IOF A;  1L0L B;  3E4A A;  1P84 A;  3H44 A;  4D6T B;  1EZV B;  2BCC B;  3N56 A;  3CX5 A;  3H1J B;  1NTK B;  1SQX B;  1NTZ A;  1BGY B;  4LTE A;  2G49 A;  3IH6 A; 
#chains in the Genus database with same CATH homology
 3OFI A;  1BE3 B;  1BCC A;  1SQV A;  4PFC A;  5EUF A;  1NTM B;  1SQP A;  3CWB A;  1KYO A;  2IBZ A;  3GO9 A;  3P7O A;  4DTT A;  5KLV A;  4D6T O;  4GSF A;  1SQB A;  3L75 B;  3L71 B;  1HR9 B;  4PD4 A;  3TGU A;  3H1H A;  1HR8 B;  4NGE D;  2FYU B;  3L73 B;  1PP9 B;  3H1I B;  1NU1 B;  2G54 A;  1HR6 B;  3TUV A;  3HGZ A;  4NGE A;  1EZV A;  4IFH A;  3H1L A;  3H1J A;  2JBU A;  3AMJ A;  2YPU A;  1NTK A;  3E4Z A;  3L74 B;  4PF7 A;  2A06 B;  3CWW A;  1PPJ A;  4L3T B;  1HR7 B;  3QZ2 A;  4GSC A;  2G47 A;  3L70 A;  3GWB A;  4RPU B;  4U3F B;  4DWK A;  4M1C A;  4PES A;  2JG4 A;  3L75 A;  3HDI A;  1NTZ B;  1SQQ A;  3L71 A;  1HR9 A;  1L0N B;  2FYU A;  3L72 A;  1PP9 A;  1BCC B;  3BCC B;  1L0L A;  3H1I A;  2WBY A;  1Q2L A;  2G56 A;  4D6T A;  4PF9 A;  2BCC A;  1NU1 A;  4RE9 A;  1KB9 B;  1HR6 A;  3CWB B;  4QIA A;  1KYO B;  3H1K B;  5KLV B;  2WC0 A;  1SQX A;  3IVL A;  3CXH B;  1SQB B;  1BGY A;  4PD4 B;  3TGU B;  2G48 A;  3P7L A;  1BE3 A;  2A06 A;  1P84 B;  4GS8 A;  1HR7 A;  1NTM A;  3CX5 B;  3N57 A;  4RAL A;  4RPU A;  4U3F A;  3H1L B;  3AMJ B;  1HR8 A;  3L73 A;  3EOQ A;  1L0N A;  1SQV B;  1PPJ B;  3BCC A;  1SQP B;  5CJO A;  2IBZ B;  4NNZ A;  3L70 B;  1KB9 A;  2FGE A;  3D3Y A;  3H1K A;  3CXH A;  2WK3 A;  3E50 A;  3H1H B;  3L74 A;  4XEA A;  1SQQ B;  3AMI A;  4NXO A;  4L3T A;  3L72 B;  4IOF A;  1L0L B;  3E4A A;  1P84 A;  3H44 A;  4D6T B;  1EZV B;  2BCC B;  3N56 A;  3CX5 A;  3H1J B;  1NTK B;  1SQX B;  1NTZ A;  1BGY B;  4LTE A;  2G49 A;  3IH6 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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