3HGXA

Crystal structure of pseudomonas aeruginosa isochorismate-pyruvate lyase k42a mutant in complex with salicylate and pyruvate
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
99
structure length
99
Chain Sequence
MKTPEDCTGLADIREAIDRIDLDIVQALGRRMDYVKAASRFAASEAAIPAPERVAAMLPERARWAEENGLDAPFVEGLFAQIIHWYIAEQIKYWRQTRG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-function analyses of isochorismate-pyruvate lyase from Pseudomonas aeruginosa suggest differing catalytic mechanisms for the two pericyclic reactions of this bifunctional enzyme.
pubmed doi rcsb
molecule tags Lyase
source organism Pseudomonas aeruginosa
molecule keywords Salicylate biosynthesis protein pchB
total genus 39
structure length 99
sequence length 99
chains with identical sequence B
ec nomenclature ec 4.2.99.21: Isochorismate lyase.
pdb deposition date 2009-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01817 CM_2 Chorismate mutase type II
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.59.10 Mainly Alpha Up-down Bundle Chorismate Mutase Domain, subunit A Chorismate mutase 3hgxA00
2D8EA 2QBVA 2D8DA 5CKXC 2H9CA 3NVTA 1YBZA 2W19C 2GTVX 2VKLA 3HGWA 2W1AC 1ECMA 2H9DA 3RETA 3HGXA 3RMIA 3TFCA 3REMA
chains in the Genus database with same CATH superfamily
2D8EA 2QBVA 2D8DA 5CKXC 2H9CA 3NVTA 1YBZA 3A2KA 1NI5A 2W19C 2GTVX 1WY5A 2VKLA 3HGWA 2W1AC 1ECMA 2H9DA 3RETA 2E21A 3HGXA 2E89A 3RMIA 3TFCA 3REMA
chains in the Genus database with same CATH topology
2D8EA 2QBVA 2D8DA 5CKXC 2H9CA 3NVTA 1YBZA 2W19C 2GTVX 2VKLA 3HGWA 2W1AC 1ECMA 2H9DA 3RETA 3HGXA 3RMIA 3TFCA 3REMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D8E A;  2QBV A;  2D8D A;  5CKX C;  2H9C A;  3NVT A;  1YBZ A;  2W19 C;  2GTV X;  2VKL A;  3HGW A;  2W1A C;  1ECM A;  2H9D A;  3RET A;  3HGX A;  3RMI A;  3TFC A;  3REM A; 
#chains in the Genus database with same CATH topology
 2D8E A;  2QBV A;  2D8D A;  5CKX C;  2H9C A;  3NVT A;  1YBZ A;  3A2K A;  1NI5 A;  2W19 C;  2GTV X;  1WY5 A;  2VKL A;  3HGW A;  2W1A C;  1ECM A;  2H9D A;  3RET A;  2E21 A;  3HGX A;  2E89 A;  3RMI A;  3TFC A;  3REM A; 
#chains in the Genus database with same CATH homology
 2D8E A;  2QBV A;  2D8D A;  5CKX C;  2H9C A;  3NVT A;  1YBZ A;  2W19 C;  2GTV X;  2VKL A;  3HGW A;  2W1A C;  1ECM A;  2H9D A;  3RET A;  3HGX A;  3RMI A;  3TFC A;  3REM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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