5LCWZ

Cryo-em structure of the anaphase-promoting complex/cyclosome, in complex with the mitotic checkpoint complex (apc/c-mcc) at 4.2 angstrom resolution
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
195
structure length
195
Chain Sequence
EQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular basis of APC/C regulation by the spindle assembly checkpoint.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords Anaphase-promoting complex subunit 1
total genus 57
structure length 195
sequence length 195
ec nomenclature
pdb deposition date 2016-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
Z PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 5lcwZ00
4FJOC 4EXTC 1DUJA 4TZOA 4J2GA 2V64D 4AEZB 3ABEC 4TZNA 4TZQA 4TZLA 1S2HA 3ABDA 4TRKA 4TZMA 2VFXA 1KLQA 5LCWZ 3GMHA 4GK5A 2QYFA 1GO4A 4TZJA 5C50B 4YK8B 4GK0A 4TZSA 2V64A 3VU7C
chains in the Genus database with same CATH superfamily
4FJOC 4EXTC 1DUJA 4TZOA 2QYFB 4J2GA 2V64D 4AEZB 3ABEC 4TZNA 4TZQA 4TZLA 1S2HA 3ABDA 4TRKA 4TZMA 2VFXA 1KLQA 5LCWZ 3GMHA 4GK5A 2QYFA 1GO4A 4TZJA 5C50B 4YK8B 4GK0A 4TZSA 2V64A 3VU7C
chains in the Genus database with same CATH topology
4FJOC 4EXTC 1DUJA 4TZOA 4J2GA 2V64D 4AEZB 3ABEC 4TZNA 4TZQA 4TZLA 1S2HA 3ABDA 4TRKA 4TZMA 2VFXA 1KLQA 5LCWZ 3GMHA 4GK5A 2QYFA 1GO4A 4TZJA 5C50B 4YK8B 4GK0A 4TZSA 2V64A 3VU7C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FJO C;  4EXT C;  1DUJ A;  4TZO A;  4J2G A;  2V64 D;  4AEZ B;  3ABE C;  4TZN A;  4TZQ A;  4TZL A;  1S2H A;  3ABD A;  4TRK A;  4TZM A;  2VFX A;  1KLQ A;  5LCW Z;  3GMH A;  4GK5 A;  2QYF A;  1GO4 A;  4TZJ A;  5C50 B;  4YK8 B;  4GK0 A;  4TZS A;  2V64 A;  3VU7 C; 
#chains in the Genus database with same CATH topology
 4FJO C;  4EXT C;  1DUJ A;  4TZO A;  2QYF B;  4J2G A;  2V64 D;  4AEZ B;  3ABE C;  4TZN A;  4TZQ A;  4TZL A;  1S2H A;  3ABD A;  4TRK A;  4TZM A;  2VFX A;  1KLQ A;  5LCW Z;  3GMH A;  4GK5 A;  2QYF A;  1GO4 A;  4TZJ A;  5C50 B;  4YK8 B;  4GK0 A;  4TZS A;  2V64 A;  3VU7 C; 
#chains in the Genus database with same CATH homology
 4FJO C;  4EXT C;  1DUJ A;  4TZO A;  4J2G A;  2V64 D;  4AEZ B;  3ABE C;  4TZN A;  4TZQ A;  4TZL A;  1S2H A;  3ABD A;  4TRK A;  4TZM A;  2VFX A;  1KLQ A;  5LCW Z;  3GMH A;  4GK5 A;  2QYF A;  1GO4 A;  4TZJ A;  5C50 B;  4YK8 B;  4GK0 A;  4TZS A;  2V64 A;  3VU7 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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