1AVVA

Hiv-1 nef protein, unliganded core domain
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
130
structure length
99
Chain Sequence
VPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPEVLEWRFDSRLAFHHVARELHPEYF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
pubmed doi rcsb
molecule tags Myristylation
source organism Human immunodeficiency virus 1
molecule keywords NEGATIVE FACTOR
total genus 24
structure length 99
sequence length 130
ec nomenclature
pdb deposition date 1997-09-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 1avvA00
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH superfamily
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH topology
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
#chains in the Genus database with same CATH topology
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
#chains in the Genus database with same CATH homology
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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