3REAA

Hiv-1 nef protein in complex with engineered hck-sh3 domain
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
150
structure length
127
Chain Sequence
NADSAWLEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEDAEKEVLVWRFDSKLAFHHMARELHPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding
molecule keywords Protein Nef
publication title Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
pubmed doi rcsb
source organism Hiv-1 m:b_arv2/sf2
total genus 34
structure length 127
sequence length 150
chains with identical sequence C
ec nomenclature
pdb deposition date 2011-04-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 3reaA00
1EFNB 3IOZA 4U5WA 3IK5A 2XI1B 3RBBA 4ORZB 3REBA 4EN2B 1AVVA 4D8DB 4EMZB 2NEFA 4NEEC 2XI1A 1AVZA 3REAA
chains in the Genus database with same CATH superfamily
1EFNB 3IOZA 4U5WA 3IK5A 2XI1B 3RBBA 4ORZB 3REBA 4EN2B 1AVVA 4D8DB 4EMZB 2NEFA 4NEEC 2XI1A 1AVZA 3REAA
chains in the Genus database with same CATH topology
1EFNB 3IOZA 4U5WA 3IK5A 2XI1B 3RBBA 4ORZB 3REBA 4EN2B 1AVVA 4D8DB 4EMZB 2NEFA 4NEEC 2XI1A 1AVZA 3REAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EFN B;  3IOZ A;  4U5W A;  3IK5 A;  2XI1 B;  3RBB A;  4ORZ B;  3REB A;  4EN2 B;  1AVV A;  4D8D B;  4EMZ B;  2NEF A;  4NEE C;  2XI1 A;  1AVZ A;  3REA A; 
#chains in the Genus database with same CATH topology
 1EFN B;  3IOZ A;  4U5W A;  3IK5 A;  2XI1 B;  3RBB A;  4ORZ B;  3REB A;  4EN2 B;  1AVV A;  4D8D B;  4EMZ B;  2NEF A;  4NEE C;  2XI1 A;  1AVZ A;  3REA A; 
#chains in the Genus database with same CATH homology
 1EFN B;  3IOZ A;  4U5W A;  3IK5 A;  2XI1 B;  3RBB A;  4ORZ B;  3REB A;  4EN2 B;  1AVV A;  4D8D B;  4EMZ B;  2NEF A;  4NEE C;  2XI1 A;  1AVZ A;  3REA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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