4EMZB

Hiv-1 nef in complex with mhc-i cytoplasmic domain and mu1 adaptin subunit of ap1 adaptor (second domain)
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
200
structure length
138
Chain Sequence
WSKSSVIGWPAVRERMRRAEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPREVLEWRFDSRLAFHHVARELHPEYFK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Viral protein/immune system
molecule keywords Protein Nef
publication title Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
pubmed doi rcsb
source organism Human immunodeficiency virus 1
total genus 30
structure length 138
sequence length 200
chains with identical sequence C
ec nomenclature
pdb deposition date 2012-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00469 F-protein Negative factor, (F-Protein) or Nef
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 4emzB00
4EN2B 1EFNB 2XI1A 3REBA 2NEFA 3REAA 2XI1B 1AVVA 4D8DB 4NEEC 4U5WA 3IOZA 4ORZB 1AVZA 3IK5A 3RBBA 4EMZB
chains in the Genus database with same CATH superfamily
4EN2B 1EFNB 2XI1A 3REBA 2NEFA 3REAA 2XI1B 1AVVA 4D8DB 4NEEC 4U5WA 3IOZA 4ORZB 1AVZA 3IK5A 3RBBA 4EMZB
chains in the Genus database with same CATH topology
4EN2B 1EFNB 2XI1A 3REBA 2NEFA 3REAA 2XI1B 1AVVA 4D8DB 4NEEC 4U5WA 3IOZA 4ORZB 1AVZA 3IK5A 3RBBA 4EMZB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EN2 B;  1EFN B;  2XI1 A;  3REB A;  2NEF A;  3REA A;  2XI1 B;  1AVV A;  4D8D B;  4NEE C;  4U5W A;  3IOZ A;  4ORZ B;  1AVZ A;  3IK5 A;  3RBB A;  4EMZ B; 
#chains in the Genus database with same CATH topology
 4EN2 B;  1EFN B;  2XI1 A;  3REB A;  2NEF A;  3REA A;  2XI1 B;  1AVV A;  4D8D B;  4NEE C;  4U5W A;  3IOZ A;  4ORZ B;  1AVZ A;  3IK5 A;  3RBB A;  4EMZ B; 
#chains in the Genus database with same CATH homology
 4EN2 B;  1EFN B;  2XI1 A;  3REB A;  2NEF A;  3REA A;  2XI1 B;  1AVV A;  4D8D B;  4NEE C;  4U5W A;  3IOZ A;  4ORZ B;  1AVZ A;  3IK5 A;  3RBB A;  4EMZ B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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