1O5EL

Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa)
Total Genus 21

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
110
structure length
110
Chain Sequence
PLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGAAGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLP

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTIV1 (12-15)TVIII1 (7-10)S1 (9-11)S7 (99-106)AH2 (61-64)TI3 (95-98)TI1 (22-25)TIV2 (13-16)S2 (18-22)TI'1 (66-69)S3 (27-31)AH1 (36-48)S4 (52-60)S6 (90-93)O1 (32-95)3H2 (86-88)S5 (72-75)TIV3 (83-86)3H1 (77-82)TI2 (23-26)Updating...
connected with : NaN
publication title Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
pubmed doi rcsb
molecule keywords Serine protease hepsin
molecule tags Serine protease, hydrolase
source organism Homo sapiens
total genus 21
structure length 110
sequence length 110
ec nomenclature ec 3.4.21.106: Hepsin.
pdb deposition date 2003-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF09272 Hepsin-SRCR Hepsin, SRCR domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.250.10 Alpha Beta Roll Mac-2 Binding Protein SRCR-like domain 1o5eL00
2JA4A 5CE1A 5JFBA 2JP0A 1Z8GA 1BY2A 2JOPA 2OY3A 2OYAA 3T2NA 1O5EL 1O5FL 2OTTX 2XRCA 1P57A
chains in the Genus database with same CATH superfamily
2JA4A 5CE1A 5JFBA 2JP0A 1Z8GA 1BY2A 2JOPA 2OY3A 2OYAA 3T2NA 1O5EL 1O5FL 2OTTX 2XRCA 1P57A
chains in the Genus database with same CATH topology
2JA4A 5CE1A 5JFBA 2JP0A 1Z8GA 1BY2A 2JOPA 2OY3A 2OYAA 3T2NA 1O5EL 1O5FL 2OTTX 2XRCA 1P57A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JA4 A;  5CE1 A;  5JFB A;  2JP0 A;  1Z8G A;  1BY2 A;  2JOP A;  2OY3 A;  2OYA A;  3T2N A;  1O5E L;  1O5F L;  2OTT X;  2XRC A;  1P57 A; 
#chains in the Genus database with same CATH topology
 2JA4 A;  5CE1 A;  5JFB A;  2JP0 A;  1Z8G A;  1BY2 A;  2JOP A;  2OY3 A;  2OYA A;  3T2N A;  1O5E L;  1O5F L;  2OTT X;  2XRC A;  1P57 A; 
#chains in the Genus database with same CATH homology
 2JA4 A;  5CE1 A;  5JFB A;  2JP0 A;  1Z8G A;  1BY2 A;  2JOP A;  2OY3 A;  2OYA A;  3T2N A;  1O5E L;  1O5F L;  2OTT X;  2XRC A;  1P57 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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