2L29A

Complex structure of e4 mutant human igf2r domain 11 bound to igf-ii
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
142
structure length
142
Chain Sequence
MKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSKSGVVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords Insulin-like growth factor 2 receptor variant
total genus 26
structure length 142
sequence length 142
ec nomenclature
pdb deposition date 2010-08-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2l29A00
2KVBA 1GQBA 3K41A 1Q25A 1E6FA 3AIHA 1GP0A 2RLBA 2LVXA 2CNJD 2L2GA 1C39A 2N1HA 1SYOA 2M6TA 1GP3A 3K43A 4XQMA 2L2AA 2LLAA 3K42A 2KVAA 1M6PA 2V5OA 1KEOA 2L29A 2RL9A 2V5NA 2M68A 2L21A 5IEIA 2RL8A 1SZ0A 3CY4A 2RL7A
chains in the Genus database with same CATH superfamily
2KVBA 1GQBA 3K41A 1Q25A 1E6FA 3AIHA 1GP0A 2RLBA 2LVXA 2CNJD 2L2GA 1C39A 2N1HA 1SYOA 2M6TA 1GP3A 3K43A 4XQMA 2L2AA 2LLAA 3K42A 2KVAA 1M6PA 2V5OA 1KEOA 2L29A 2RL9A 2V5NA 2M68A 2L21A 5IEIA 2RL8A 1SZ0A 3CY4A 2RL7A
chains in the Genus database with same CATH topology
2KVBA 1GQBA 3K41A 1Q25A 1E6FA 3AIHA 1GP0A 2RLBA 2LVXA 2CNJD 2L2GA 1C39A 2N1HA 1SYOA 2M6TA 1GP3A 3K43A 4XQMA 2L2AA 2LLAA 3K42A 2KVAA 1M6PA 2V5OA 1KEOA 2L29A 2RL9A 2V5NA 2M68A 2L21A 5IEIA 2RL8A 1SZ0A 3CY4A 2RL7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KVB A;  1GQB A;  3K41 A;  1Q25 A;  1E6F A;  3AIH A;  1GP0 A;  2RLB A;  2LVX A;  2CNJ D;  2L2G A;  1C39 A;  2N1H A;  1SYO A;  2M6T A;  1GP3 A;  3K43 A;  4XQM A;  2L2A A;  2LLA A;  3K42 A;  2KVA A;  1M6P A;  2V5O A;  1KEO A;  2L29 A;  2RL9 A;  2V5N A;  2M68 A;  2L21 A;  5IEI A;  2RL8 A;  1SZ0 A;  3CY4 A;  2RL7 A; 
#chains in the Genus database with same CATH topology
 2KVB A;  1GQB A;  3K41 A;  1Q25 A;  1E6F A;  3AIH A;  1GP0 A;  2RLB A;  2LVX A;  2CNJ D;  2L2G A;  1C39 A;  2N1H A;  1SYO A;  2M6T A;  1GP3 A;  3K43 A;  4XQM A;  2L2A A;  2LLA A;  3K42 A;  2KVA A;  1M6P A;  2V5O A;  1KEO A;  2L29 A;  2RL9 A;  2V5N A;  2M68 A;  2L21 A;  5IEI A;  2RL8 A;  1SZ0 A;  3CY4 A;  2RL7 A; 
#chains in the Genus database with same CATH homology
 2KVB A;  1GQB A;  3K41 A;  1Q25 A;  1E6F A;  3AIH A;  1GP0 A;  2RLB A;  2LVX A;  2CNJ D;  2L2G A;  1C39 A;  2N1H A;  1SYO A;  2M6T A;  1GP3 A;  3K43 A;  4XQM A;  2L2A A;  2LLA A;  3K42 A;  2KVA A;  1M6P A;  2V5O A;  1KEO A;  2L29 A;  2RL9 A;  2V5N A;  2M68 A;  2L21 A;  5IEI A;  2RL8 A;  1SZ0 A;  3CY4 A;  2RL7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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