2L2AA

Mutated domain 11 of the cytoplasmic region of the cation-independent mannose-6-phosphate receptor
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
142
structure length
142
Chain Sequence
MKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSKSGVVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transport protein
source organism Homo sapiens
publication title An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
pubmed doi rcsb
molecule keywords Insulin-like growth factor 2 receptor variant
total genus 25
structure length 142
sequence length 142
ec nomenclature
pdb deposition date 2010-08-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2l2aA00
1SZ0A 2L29A 2KVBA 1KEOA 2L2GA 1E6FA 2M68A 1GP3A 1SYOA 2LLAA 2V5OA 2RLBA 2RL9A 1C39A 4XQMA 1GQBA 2KVAA 3K43A 2RL8A 1GP0A 3K41A 3CY4A 5IEIA 2L2AA 2N1HA 1Q25A 3K42A 1M6PA 2LVXA 2M6TA 2L21A 3AIHA 2V5NA 2RL7A 2CNJD
chains in the Genus database with same CATH superfamily
1SZ0A 2L29A 2KVBA 1KEOA 2L2GA 1E6FA 2M68A 1GP3A 1SYOA 2LLAA 2V5OA 2RLBA 2RL9A 1C39A 4XQMA 1GQBA 2KVAA 3K43A 2RL8A 1GP0A 3K41A 3CY4A 5IEIA 2L2AA 2N1HA 1Q25A 3K42A 1M6PA 2LVXA 2M6TA 2L21A 3AIHA 2V5NA 2RL7A 2CNJD
chains in the Genus database with same CATH topology
1SZ0A 2L29A 2KVBA 1KEOA 2L2GA 1E6FA 2M68A 1GP3A 1SYOA 2LLAA 2V5OA 2RLBA 2RL9A 1C39A 4XQMA 1GQBA 2KVAA 3K43A 2RL8A 1GP0A 3K41A 3CY4A 5IEIA 2L2AA 2N1HA 1Q25A 3K42A 1M6PA 2LVXA 2M6TA 2L21A 3AIHA 2V5NA 2RL7A 2CNJD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SZ0 A;  2L29 A;  2KVB A;  1KEO A;  2L2G A;  1E6F A;  2M68 A;  1GP3 A;  1SYO A;  2LLA A;  2V5O A;  2RLB A;  2RL9 A;  1C39 A;  4XQM A;  1GQB A;  2KVA A;  3K43 A;  2RL8 A;  1GP0 A;  3K41 A;  3CY4 A;  5IEI A;  2L2A A;  2N1H A;  1Q25 A;  3K42 A;  1M6P A;  2LVX A;  2M6T A;  2L21 A;  3AIH A;  2V5N A;  2RL7 A;  2CNJ D; 
#chains in the Genus database with same CATH topology
 1SZ0 A;  2L29 A;  2KVB A;  1KEO A;  2L2G A;  1E6F A;  2M68 A;  1GP3 A;  1SYO A;  2LLA A;  2V5O A;  2RLB A;  2RL9 A;  1C39 A;  4XQM A;  1GQB A;  2KVA A;  3K43 A;  2RL8 A;  1GP0 A;  3K41 A;  3CY4 A;  5IEI A;  2L2A A;  2N1H A;  1Q25 A;  3K42 A;  1M6P A;  2LVX A;  2M6T A;  2L21 A;  3AIH A;  2V5N A;  2RL7 A;  2CNJ D; 
#chains in the Genus database with same CATH homology
 1SZ0 A;  2L29 A;  2KVB A;  1KEO A;  2L2G A;  1E6F A;  2M68 A;  1GP3 A;  1SYO A;  2LLA A;  2V5O A;  2RLB A;  2RL9 A;  1C39 A;  4XQM A;  1GQB A;  2KVA A;  3K43 A;  2RL8 A;  1GP0 A;  3K41 A;  3CY4 A;  5IEI A;  2L2A A;  2N1H A;  1Q25 A;  3K42 A;  1M6P A;  2LVX A;  2M6T A;  2L21 A;  3AIH A;  2V5N A;  2RL7 A;  2CNJ D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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