2XI1A

Crystal structure of the hiv-1 nef sequenced from a patient's sample
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
130
structure length
101
Chain Sequence
VPLRPMTYKGAVDLSFFLKEKGGLEGLVYSQREKEILDLWVYHTQGYFPDWQCYTPGPGVRYPLTFGWCFKLVPVDEVLKWKFDSHLAHTHMARELHPEYF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef.
pubmed doi rcsb
molecule tags Viral protein
source organism Human immunodeficiency virus type 1 (bh5 isolate)
molecule keywords NEF
total genus 28
structure length 101
sequence length 130
ec nomenclature
pdb deposition date 2010-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00469 F-protein Negative factor, (F-Protein) or Nef
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 2xi1A00
2NEFA 3REAA 4NEEC 4EMZB 3IOZA 3RBBA 4U5WA 3REBA 3IK5A 4ORZB 2XI1A 4D8DB 1AVVA 4EN2B 1AVZA 2XI1B 1EFNB
chains in the Genus database with same CATH superfamily
2NEFA 3REAA 4NEEC 4EMZB 3IOZA 3RBBA 4U5WA 3REBA 3IK5A 4ORZB 2XI1A 4D8DB 1AVVA 4EN2B 1AVZA 2XI1B 1EFNB
chains in the Genus database with same CATH topology
2NEFA 3REAA 4NEEC 4EMZB 3IOZA 3RBBA 4U5WA 3REBA 3IK5A 4ORZB 2XI1A 4D8DB 1AVVA 4EN2B 1AVZA 2XI1B 1EFNB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NEF A;  3REA A;  4NEE C;  4EMZ B;  3IOZ A;  3RBB A;  4U5W A;  3REB A;  3IK5 A;  4ORZ B;  2XI1 A;  4D8D B;  1AVV A;  4EN2 B;  1AVZ A;  2XI1 B;  1EFN B; 
#chains in the Genus database with same CATH topology
 2NEF A;  3REA A;  4NEE C;  4EMZ B;  3IOZ A;  3RBB A;  4U5W A;  3REB A;  3IK5 A;  4ORZ B;  2XI1 A;  4D8D B;  1AVV A;  4EN2 B;  1AVZ A;  2XI1 B;  1EFN B; 
#chains in the Genus database with same CATH homology
 2NEF A;  3REA A;  4NEE C;  4EMZ B;  3IOZ A;  3RBB A;  4U5W A;  3REB A;  3IK5 A;  4ORZ B;  2XI1 A;  4D8D B;  1AVV A;  4EN2 B;  1AVZ A;  2XI1 B;  1EFN B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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