3TM2A

Crystal structure of mature thnt with a covalently bound product mimic
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
374
structure length
367
Chain Sequence
GIGGVPGPHNGLTDVPGVRVGHAGRTGDGWLTGVTVVLAPPGGAVAAVDVRGGGPGTRETDALDPRNLVQTIDAVVLTGGSAFGLDAAGGVAAWLEEQGRGFPVGADPSQVVPVVPAAALFDLGRGGTWRARPDAALGRAAVEAAAARPEGDPVEQGGVGAGTGAVVGGLKGGIGTASVVLDSGATVAALAAVNAAGSAVDPATGVLYGARTGLPGEFAGYGVPDAIGADTHARARARLAEAAEETARRRATTLAVVATDATLTRAQAQKLAGTAHDGLARAVRPVHLLSDGDTVFALSTGRRPLLPDRPDATAARAFGVHLEAGALNEVLAAGADVLTRAVVHAVLAATGVDTPGGVHPSYRELYA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Streptomyces cattleya
molecule keywords cysteine transferase
total genus 115
structure length 367
sequence length 374
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03576 Peptidase_S58 Peptidase family S58
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.70.12 Alpha Beta 4-Layer Sandwich L-amino peptidase D-ALA esterase/amidase L-amino peptidase D-ALA esterase/amidase 3tm2A00
1VZ6A 1VZ8A 3N33A 3NFBA 2DRHA 3AXGA 4IHDA 1VZ7A 3IT6A 2VZKA 1B65A 2YEPA 2V4IA 3NDVA 3TM1A 1VRAA 4IHEA 3N5IA 3N2WA 3IT4A 3S3UA 3TM2A
chains in the Genus database with same CATH superfamily
1VZ6A 1VZ8A 3N33A 3NFBA 2DRHA 3AXGA 4IHDA 1VZ7A 3IT6A 2VZKA 1B65A 2YEPA 2V4IA 3NDVA 3TM1A 1VRAA 4IHEA 3N5IA 3N2WA 3IT4A 3S3UA 3TM2A
chains in the Genus database with same CATH topology
1VZ6A 1VZ8A 3N33A 3NFBA 2DRHA 3AXGA 4IHDA 1VZ7A 3IT6A 2VZKA 1B65A 2YEPA 2V4IA 3NDVA 3TM1A 1VRAA 4IHEA 3N5IA 3N2WA 3IT4A 3S3UA 3TM2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VZ6 A;  1VZ8 A;  3N33 A;  3NFB A;  2DRH A;  3AXG A;  4IHD A;  1VZ7 A;  3IT6 A;  2VZK A;  1B65 A;  2YEP A;  2V4I A;  3NDV A;  3TM1 A;  1VRA A;  4IHE A;  3N5I A;  3N2W A;  3IT4 A;  3S3U A;  3TM2 A; 
#chains in the Genus database with same CATH topology
 1VZ6 A;  1VZ8 A;  3N33 A;  3NFB A;  2DRH A;  3AXG A;  4IHD A;  1VZ7 A;  3IT6 A;  2VZK A;  1B65 A;  2YEP A;  2V4I A;  3NDV A;  3TM1 A;  1VRA A;  4IHE A;  3N5I A;  3N2W A;  3IT4 A;  3S3U A;  3TM2 A; 
#chains in the Genus database with same CATH homology
 1VZ6 A;  1VZ8 A;  3N33 A;  3NFB A;  2DRH A;  3AXG A;  4IHD A;  1VZ7 A;  3IT6 A;  2VZK A;  1B65 A;  2YEP A;  2V4I A;  3NDV A;  3TM1 A;  1VRA A;  4IHE A;  3N5I A;  3N2W A;  3IT4 A;  3S3U A;  3TM2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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