3REBA

Hiv-1 nef protein in complex with engineered hck-sh3 domain
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
134
structure length
106
Chain Sequence
VRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEVLVWRFDSKLAFHHMARELHPEYY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
pubmed doi rcsb
molecule tags Protein binding
source organism Hiv-1 m:b_arv2/sf2
molecule keywords Protein Nef
total genus 29
structure length 106
sequence length 134
chains with identical sequence C
ec nomenclature
pdb deposition date 2011-04-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 3rebA00
4U5WA 3IK5A 4EN2B 3REBA 4EMZB 1EFNB 2XI1A 3RBBA 4D8DB 3REAA 2NEFA 4ORZB 1AVZA 3IOZA 2XI1B 1AVVA 4NEEC
chains in the Genus database with same CATH superfamily
4U5WA 3IK5A 4EN2B 3REBA 4EMZB 1EFNB 2XI1A 3RBBA 4D8DB 3REAA 2NEFA 4ORZB 1AVZA 3IOZA 2XI1B 1AVVA 4NEEC
chains in the Genus database with same CATH topology
4U5WA 3IK5A 4EN2B 3REBA 4EMZB 1EFNB 2XI1A 3RBBA 4D8DB 3REAA 2NEFA 4ORZB 1AVZA 3IOZA 2XI1B 1AVVA 4NEEC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U5W A;  3IK5 A;  4EN2 B;  3REB A;  4EMZ B;  1EFN B;  2XI1 A;  3RBB A;  4D8D B;  3REA A;  2NEF A;  4ORZ B;  1AVZ A;  3IOZ A;  2XI1 B;  1AVV A;  4NEE C; 
#chains in the Genus database with same CATH topology
 4U5W A;  3IK5 A;  4EN2 B;  3REB A;  4EMZ B;  1EFN B;  2XI1 A;  3RBB A;  4D8D B;  3REA A;  2NEF A;  4ORZ B;  1AVZ A;  3IOZ A;  2XI1 B;  1AVV A;  4NEE C; 
#chains in the Genus database with same CATH homology
 4U5W A;  3IK5 A;  4EN2 B;  3REB A;  4EMZ B;  1EFN B;  2XI1 A;  3RBB A;  4D8D B;  3REA A;  2NEF A;  4ORZ B;  1AVZ A;  3IOZ A;  2XI1 B;  1AVV A;  4NEE C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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