4EMZB

Hiv-1 nef in complex with mhc-i cytoplasmic domain and mu1 adaptin subunit of ap1 adaptor (second domain)
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
200
structure length
138
Chain Sequence
WSKSSVIGWPAVRERMRRAEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPREVLEWRFDSRLAFHHVARELHPEYFK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
pubmed doi rcsb
molecule tags Viral protein/immune system
source organism Human immunodeficiency virus 1
molecule keywords Protein Nef
total genus 30
structure length 138
sequence length 200
chains with identical sequence C
ec nomenclature
pdb deposition date 2012-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00469 F-protein Negative factor, (F-Protein) or Nef
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 4emzB00
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH superfamily
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH topology
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
#chains in the Genus database with same CATH topology
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
#chains in the Genus database with same CATH homology
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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