4EN2B

Hiv-1 nef in complex with mhc-i cytoplasmic domain and mu1 adaptin subunit of ap1 adaptor (second domain)
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
199
structure length
149
Chain Sequence
SKSSVIGWPAVRERMRRAEPAEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENDPEREVLEWRFDSRLAFHHVARELHPEYFK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
pubmed doi rcsb
molecule tags Viral protein/immune system
source organism Mus musculus
molecule keywords AP-1 complex subunit mu-1
total genus 41
structure length 149
sequence length 199
chains with identical sequence C
ec nomenclature
pdb deposition date 2012-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00469 F-protein Negative factor, (F-Protein) or Nef
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 4en2B00
2NEFA 3REAA 4U5WA 1AVZA 3IOZA 3REBA 4EMZB 3RBBA 1EFNB 4EN2B 4NEEC 2XI1A 3IK5A 4ORZB 4D8DB 2XI1B 1AVVA
chains in the Genus database with same CATH superfamily
2NEFA 3REAA 4U5WA 1AVZA 3IOZA 3REBA 4EMZB 3RBBA 1EFNB 4EN2B 4NEEC 2XI1A 3IK5A 4ORZB 4D8DB 2XI1B 1AVVA
chains in the Genus database with same CATH topology
2NEFA 3REAA 4U5WA 1AVZA 3IOZA 3REBA 4EMZB 3RBBA 1EFNB 4EN2B 4NEEC 2XI1A 3IK5A 4ORZB 4D8DB 2XI1B 1AVVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NEF A;  3REA A;  4U5W A;  1AVZ A;  3IOZ A;  3REB A;  4EMZ B;  3RBB A;  1EFN B;  4EN2 B;  4NEE C;  2XI1 A;  3IK5 A;  4ORZ B;  4D8D B;  2XI1 B;  1AVV A; 
#chains in the Genus database with same CATH topology
 2NEF A;  3REA A;  4U5W A;  1AVZ A;  3IOZ A;  3REB A;  4EMZ B;  3RBB A;  1EFN B;  4EN2 B;  4NEE C;  2XI1 A;  3IK5 A;  4ORZ B;  4D8D B;  2XI1 B;  1AVV A; 
#chains in the Genus database with same CATH homology
 2NEF A;  3REA A;  4U5W A;  1AVZ A;  3IOZ A;  3REB A;  4EMZ B;  3RBB A;  1EFN B;  4EN2 B;  4NEE C;  2XI1 A;  3IK5 A;  4ORZ B;  4D8D B;  2XI1 B;  1AVV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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