4GIZC

Crystal structure of full-length human papillomavirus oncoprotein e6 in complex with lxxll peptide of ubiquitin ligase e6ap at 2.55 a resolution
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
142
structure length
142
Chain Sequence
FQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFARRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYSYSLYGTTLEQQYNKPLSDLLIRCINCQKPLSPEEKQRHLDKKQRFHNIRGRWTGRCMSCSRSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.
pubmed doi rcsb
molecule keywords Maltose-binding periplasmic protein, UBIQUITIN LIGASE EA6P:
molecule tags Viral protein
source organism Escherichia coli
total genus 45
structure length 142
sequence length 142
chains with identical sequence D
ec nomenclature
pdb deposition date 2012-08-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00518 E6 Early Protein (E6)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.240.40 Alpha Beta 2-Layer Sandwich CRO Repressor CRO Repressor 4gizC01
3.30.240.40 Alpha Beta 2-Layer Sandwich CRO Repressor CRO Repressor 4gizC02
2LJYA 2LJZA 4GIZC 2FK4A 2M3LA 4XR8F 2LJXA
chains in the Genus database with same CATH superfamily
6CROA 1D1MA 5CROA 2LJXA 3ORCA 2ECSA 1COPD 2FK4A 1D1LA 2LJYA 2LJZA 3C6FA 2CW1A 2A63A 1WU7A 4XR8F 2ORCA 2OVGA 4GIZC 2M3LA 1ORCA
chains in the Genus database with same CATH topology
6CROA 1D1MA 5CROA 2LJXA 3ORCA 2ECSA 1COPD 2FK4A 1D1LA 2LJYA 2LJZA 2CW1A 2A63A 1WU7A 4XR8F 2ORCA 2OVGA 4GIZC 2M3LA 1ORCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LJY A;  2LJZ A;  4GIZ C;  2FK4 A;  2M3L A;  4XR8 F;  2LJX A; 
#chains in the Genus database with same CATH topology
 6CRO A;  1D1M A;  5CRO A;  2LJX A;  3ORC A;  2ECS A;  1COP D;  2FK4 A;  1D1L A;  2LJY A;  2LJZ A;  3C6F A;  2CW1 A;  2A63 A;  1WU7 A;  4XR8 F;  2ORC A;  2OVG A;  4GIZ C;  2M3L A;  1ORC A; 
#chains in the Genus database with same CATH homology
 6CRO A;  1D1M A;  5CRO A;  2LJX A;  3ORC A;  2ECS A;  1COP D;  2FK4 A;  1D1L A;  2LJY A;  2LJZ A;  2CW1 A;  2A63 A;  1WU7 A;  4XR8 F;  2ORC A;  2OVG A;  4GIZ C;  2M3L A;  1ORC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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