4NEEC

Crystal structure of ap-2 alpha/simga2 complex bound to hiv-1 nef
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
148
structure length
139
Chain Sequence
XXXXXXXPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4.
pubmed doi rcsb
molecule tags Viral protein/protein transport
source organism Rattus norvegicus
molecule keywords AP-2 complex subunit sigma
total genus 37
structure length 139
sequence length 148
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2013-10-29
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 4neeC00
1AVVA 3IOZA 3REAA 4EN2B 4NEEC 3REBA 4D8DB 4U5WA 4ORZB 3RBBA 2XI1A 4EMZB 1AVZA 3IK5A 1EFNB 2NEFA 2XI1B
chains in the Genus database with same CATH superfamily
1AVVA 3IOZA 3REAA 4EN2B 4NEEC 3REBA 4D8DB 4U5WA 4ORZB 3RBBA 2XI1A 4EMZB 1AVZA 3IK5A 1EFNB 2NEFA 2XI1B
chains in the Genus database with same CATH topology
1AVVA 3IOZA 3REAA 4EN2B 4NEEC 3REBA 4D8DB 4U5WA 4ORZB 3RBBA 2XI1A 4EMZB 1AVZA 3IK5A 1EFNB 2NEFA 2XI1B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AVV A;  3IOZ A;  3REA A;  4EN2 B;  4NEE C;  3REB A;  4D8D B;  4U5W A;  4ORZ B;  3RBB A;  2XI1 A;  4EMZ B;  1AVZ A;  3IK5 A;  1EFN B;  2NEF A;  2XI1 B; 
#chains in the Genus database with same CATH topology
 1AVV A;  3IOZ A;  3REA A;  4EN2 B;  4NEE C;  3REB A;  4D8D B;  4U5W A;  4ORZ B;  3RBB A;  2XI1 A;  4EMZ B;  1AVZ A;  3IK5 A;  1EFN B;  2NEF A;  2XI1 B; 
#chains in the Genus database with same CATH homology
 1AVV A;  3IOZ A;  3REA A;  4EN2 B;  4NEE C;  3REB A;  4D8D B;  4U5W A;  4ORZ B;  3RBB A;  2XI1 A;  4EMZ B;  1AVZ A;  3IK5 A;  1EFN B;  2NEF A;  2XI1 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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