4U5WA

Crystal structure of hiv-1 nef-sf2 core domain in complex with the src family kinase hck sh3-sh2 tandem regulatory domains
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
137
structure length
116
Chain Sequence
FPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKVEEANEVLVWRFDSKLAFHHMARELHPEYYK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.
pubmed doi rcsb
molecule tags Viral protein/transferase
source organism Human immunodeficiency virus type 1
molecule keywords Protein Nef
total genus 34
structure length 116
sequence length 137
chains with identical sequence C
ec nomenclature
pdb deposition date 2014-07-25
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.62.10 Alpha Beta 2-Layer Sandwich Nef Regulatory Factor Nef Regulatory Factor 4u5wA00
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH superfamily
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH topology
3IOZA 4D8DB 4ORZB 3IK5A 2XI1A 4U5WA 1EFNB 4EMZB 1AVVA 4NEEC 3REAA 1AVZA 2XI1B 2NEFA 4EN2B 3REBA 3RBBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
#chains in the Genus database with same CATH topology
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
#chains in the Genus database with same CATH homology
 3IOZ A;  4D8D B;  4ORZ B;  3IK5 A;  2XI1 A;  4U5W A;  1EFN B;  4EMZ B;  1AVV A;  4NEE C;  3REA A;  1AVZ A;  2XI1 B;  2NEF A;  4EN2 B;  3REB A;  3RBB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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