4XR8F

Crystal structure of the hpv16 e6/e6ap/p53 ternary complex at 2.25 a resolution
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
143
structure length
143
Chain Sequence
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYSYSLYGTTLEQQYNKPLSDLLIRCINCQKPLSPEEKQRHLDKKQRFHNIRGRWTGRCMSCSRSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
pubmed doi rcsb
molecule keywords Maltose-binding periplasmic protein, ubiquitin ligase E6AP
molecule tags Viral protein/ antitumor protein
source organism Escherichia coli
total genus 43
structure length 143
sequence length 143
chains with identical sequence H
ec nomenclature
pdb deposition date 2015-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00518 E6 Early Protein (E6)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.240.40 Alpha Beta 2-Layer Sandwich CRO Repressor CRO Repressor 4xr8F01
3.30.240.40 Alpha Beta 2-Layer Sandwich CRO Repressor CRO Repressor 4xr8F02
4GIZC 2LJZA 2LJYA 2LJXA 2FK4A 4XR8F 2M3LA
chains in the Genus database with same CATH superfamily
2ECSA 4GIZC 5CROA 4XR8F 1D1LA 2OVGA 2ORCA 1WU7A 1ORCA 2LJXA 2M3LA 1COPD 2A63A 2CW1A 2LJZA 1D1MA 2LJYA 2FK4A 3ORCA 3C6FA 6CROA
chains in the Genus database with same CATH topology
2ECSA 4GIZC 5CROA 4XR8F 1D1LA 2OVGA 2ORCA 1WU7A 1ORCA 2LJXA 2M3LA 1COPD 2A63A 2CW1A 2LJZA 1D1MA 2LJYA 2FK4A 3ORCA 6CROA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GIZ C;  2LJZ A;  2LJY A;  2LJX A;  2FK4 A;  4XR8 F;  2M3L A; 
#chains in the Genus database with same CATH topology
 2ECS A;  4GIZ C;  5CRO A;  4XR8 F;  1D1L A;  2OVG A;  2ORC A;  1WU7 A;  1ORC A;  2LJX A;  2M3L A;  1COP D;  2A63 A;  2CW1 A;  2LJZ A;  1D1M A;  2LJY A;  2FK4 A;  3ORC A;  3C6F A;  6CRO A; 
#chains in the Genus database with same CATH homology
 2ECS A;  4GIZ C;  5CRO A;  4XR8 F;  1D1L A;  2OVG A;  2ORC A;  1WU7 A;  1ORC A;  2LJX A;  2M3L A;  1COP D;  2A63 A;  2CW1 A;  2LJZ A;  1D1M A;  2LJY A;  2FK4 A;  3ORC A;  6CRO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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