4F95A

Crystal structure of human inosine triphosphate pyrophosphatase p32t variant
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
189
structure length
189
Chain Sequence
ASLVGKKIVFVTGNAKKLEEVVQILGDKFTCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Inosine triphosphate pyrophosphatase
total genus 57
structure length 189
sequence length 189
ec nomenclature ec 3.6.1.9: Nucleotide diphosphatase.
pdb deposition date 2012-05-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01725 Ham1p_like Ham1 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.950.10 Alpha Beta Alpha-Beta Complex Maf protein Maf protein 4f95A00
2ZTIA 2DVPA 1U14A 1U5WA 2CARA 2Q16A 2MJPA 2PYUA 3TQUA 4HEBA 2P5XA 1B78A 1EXCA 1VP2A 4BNQA 1V7RA 4LU1A 1ZWYA 1EX2A 2I5DA 1ZNOA 3S86A 4JHCA 4P0UA 2AMHA 1K7KA 2DVNA 2J4EA 4F95A 4OO0A 4P0EA 2DVOA 2E5XA
chains in the Genus database with same CATH superfamily
2ZTIA 2DVPA 4CTAB 1U14A 4CTAA 1U5WA 4UUXA 2CARA 2Q16A 2MJPA 2PYUA 3TQUA 4HEBA 2P5XA 1B78A 1EXCA 1VP2A 4BNQA 1V7RA 4UUWA 4LU1A 5KVKA 1ZWYA 1EX2A 2I5DA 1ZNOA 3S86A 4JHCA 2A9SA 4P0UA 2AMHA 1K7KA 2DVNA 2J4EA 4UOCA 4CT8A 4F95A 4OO0A 4CT9A 4P0EA 5KOLA 2DVOA 2E5XA
chains in the Genus database with same CATH topology
2ZTIA 2DVPA 1U14A 1U5WA 2CARA 2Q16A 2MJPA 2PYUA 3TQUA 4HEBA 2P5XA 1B78A 1EXCA 1VP2A 4BNQA 1V7RA 4LU1A 1ZWYA 1EX2A 2I5DA 1ZNOA 3S86A 4JHCA 4P0UA 2AMHA 1K7KA 2DVNA 2J4EA 4F95A 4OO0A 4P0EA 2DVOA 2E5XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZTI A;  2DVP A;  1U14 A;  1U5W A;  2CAR A;  2Q16 A;  2MJP A;  2PYU A;  3TQU A;  4HEB A;  2P5X A;  1B78 A;  1EXC A;  1VP2 A;  4BNQ A;  1V7R A;  4LU1 A;  1ZWY A;  1EX2 A;  2I5D A;  1ZNO A;  3S86 A;  4JHC A;  4P0U A;  2AMH A;  1K7K A;  2DVN A;  2J4E A;  4F95 A;  4OO0 A;  4P0E A;  2DVO A;  2E5X A; 
#chains in the Genus database with same CATH topology
 2ZTI A;  2DVP A;  4CTA B;  1U14 A;  4CTA A;  1U5W A;  4UUX A;  2CAR A;  2Q16 A;  2MJP A;  2PYU A;  3TQU A;  4HEB A;  2P5X A;  1B78 A;  1EXC A;  1VP2 A;  4BNQ A;  1V7R A;  4UUW A;  4LU1 A;  5KVK A;  1ZWY A;  1EX2 A;  2I5D A;  1ZNO A;  3S86 A;  4JHC A;  2A9S A;  4P0U A;  2AMH A;  1K7K A;  2DVN A;  2J4E A;  4UOC A;  4CT8 A;  4F95 A;  4OO0 A;  4CT9 A;  4P0E A;  5KOL A;  2DVO A;  2E5X A; 
#chains in the Genus database with same CATH homology
 2ZTI A;  2DVP A;  1U14 A;  1U5W A;  2CAR A;  2Q16 A;  2MJP A;  2PYU A;  3TQU A;  4HEB A;  2P5X A;  1B78 A;  1EXC A;  1VP2 A;  4BNQ A;  1V7R A;  4LU1 A;  1ZWY A;  1EX2 A;  2I5D A;  1ZNO A;  3S86 A;  4JHC A;  4P0U A;  2AMH A;  1K7K A;  2DVN A;  2J4E A;  4F95 A;  4OO0 A;  4P0E A;  2DVO A;  2E5X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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