5IEIA

X-ray crystallographic structure of a high affinity igf2 antagonist (domain11 ab5 rhh) based on human igf2r domain 11
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
137
structure length
132
Chain Sequence
NEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYAKGWGVYMSICGENENCPPGVGACFGRTRISVGKANKRLRYVDQVLQLVYKDGSHCPSKHGLSYKSVISFVCRPNRPMLISLDKQTCTLFFSWHTPLACE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords Cation-independent mannose-6-phosphate receptor
total genus 36
structure length 132
sequence length 137
ec nomenclature
pdb deposition date 2016-02-25
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 5ieiA00
2M68A 1GQBA 2L2GA 2RL9A 1SZ0A 3AIHA 2M6TA 2V5OA 2KVBA 2L2AA 2V5NA 1GP0A 1C39A 2RLBA 2L29A 3K41A 2LLAA 2RL7A 2RL8A 3K42A 4XQMA 2CNJD 2L21A 3K43A 1KEOA 2KVAA 1M6PA 1SYOA 3CY4A 5IEIA 2N1HA 2LVXA 1E6FA 1Q25A 1GP3A
chains in the Genus database with same CATH superfamily
2M68A 1GQBA 2L2GA 2RL9A 1SZ0A 3AIHA 2M6TA 2V5OA 2KVBA 2L2AA 2V5NA 1GP0A 1C39A 2RLBA 2L29A 3K41A 2LLAA 2RL7A 2RL8A 3K42A 4XQMA 2CNJD 2L21A 3K43A 1KEOA 2KVAA 1M6PA 1SYOA 3CY4A 5IEIA 2N1HA 2LVXA 1E6FA 1Q25A 1GP3A
chains in the Genus database with same CATH topology
2M68A 1GQBA 2L2GA 2RL9A 1SZ0A 3AIHA 2M6TA 2V5OA 2KVBA 2L2AA 2V5NA 1GP0A 1C39A 2RLBA 2L29A 3K41A 2LLAA 2RL7A 2RL8A 3K42A 4XQMA 2CNJD 2L21A 3K43A 1KEOA 2KVAA 1M6PA 1SYOA 3CY4A 5IEIA 2N1HA 2LVXA 1E6FA 1Q25A 1GP3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2M68 A;  1GQB A;  2L2G A;  2RL9 A;  1SZ0 A;  3AIH A;  2M6T A;  2V5O A;  2KVB A;  2L2A A;  2V5N A;  1GP0 A;  1C39 A;  2RLB A;  2L29 A;  3K41 A;  2LLA A;  2RL7 A;  2RL8 A;  3K42 A;  4XQM A;  2CNJ D;  2L21 A;  3K43 A;  1KEO A;  2KVA A;  1M6P A;  1SYO A;  3CY4 A;  5IEI A;  2N1H A;  2LVX A;  1E6F A;  1Q25 A;  1GP3 A; 
#chains in the Genus database with same CATH topology
 2M68 A;  1GQB A;  2L2G A;  2RL9 A;  1SZ0 A;  3AIH A;  2M6T A;  2V5O A;  2KVB A;  2L2A A;  2V5N A;  1GP0 A;  1C39 A;  2RLB A;  2L29 A;  3K41 A;  2LLA A;  2RL7 A;  2RL8 A;  3K42 A;  4XQM A;  2CNJ D;  2L21 A;  3K43 A;  1KEO A;  2KVA A;  1M6P A;  1SYO A;  3CY4 A;  5IEI A;  2N1H A;  2LVX A;  1E6F A;  1Q25 A;  1GP3 A; 
#chains in the Genus database with same CATH homology
 2M68 A;  1GQB A;  2L2G A;  2RL9 A;  1SZ0 A;  3AIH A;  2M6T A;  2V5O A;  2KVB A;  2L2A A;  2V5N A;  1GP0 A;  1C39 A;  2RLB A;  2L29 A;  3K41 A;  2LLA A;  2RL7 A;  2RL8 A;  3K42 A;  4XQM A;  2CNJ D;  2L21 A;  3K43 A;  1KEO A;  2KVA A;  1M6P A;  1SYO A;  3CY4 A;  5IEI A;  2N1H A;  2LVX A;  1E6F A;  1Q25 A;  1GP3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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