5L43 | Genus

Total Genus 278

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	278
sequence length	662
structure length	662
Chain Sequence	ENPFFAPSALPYGLPPFAEIREEHYVPAFERGMAEQLAEVEAIAGDTEAPTFDNTVAALERSGQVLTRVSAVFFNQSSSDTNPTVQEIQKQIIPKLTQHGDAIHLNRPLFARIKQISPDGLDAEQAWLLERYVTDFVRAGAELGAGDQERLKALNEELSTLSTRFEQNLLAHTNASAVIVDDVAQLDGLSDDSVKAAAETAKSRGLPGKYVIPLVLPTGQPGLAELTDRALRERIHRASIQRGVPDNEELIVRIATLRAERAKLLGYPTHAAYVVADQTAPTTEAVTEMLGKLTPPAVANAHREADELREQAGHDLEPWDWSFYAEKVLKERYAIDGRQMRPYFELDRVLRDGVFHAATLLYGITFTERPDLVGYHPDVRVFEVFNEDGSQLGLFLGDYYARPSKRGGAWMNSLVKQSTLEGTRPVVVNNLNIAKPPAGEPTLMTFEEVNTMFHEFGHALHGLFSEVHYPRFSGTAVPRDFVEYPSQVNEMWAVWPSVLANYARHWQTGDPMPKDLLDRMLKSQKYNQGYKTVEYLAATLLDWSWHTFQTPPENALTFEHEALTTAGVDLKLVPPRYRSTYFAHIWSSGYSAGYYSYIWSEVLDADTVDWFHENGGLLRENGDTFRQKLLSKGGSVDPMTAFQSFRGRTPRIEPLLDRRGLL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Astrosporangium hypotensionis k-26
publication title	Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor. pubmed doi rcsb
molecule keywords	K-26 dipeptidyl carboxypeptidase
total genus	278
structure length	662
sequence length	662
chains with identical sequence	B
ec nomenclature
pdb deposition date	2016-05-24

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.1370.10	Mainly Alpha	Orthogonal Bundle	Neurolysin; domain 3	Neurolysin, domain 3	5l43A02
1.10.1370.40	Mainly Alpha	Orthogonal Bundle	Neurolysin; domain 3	Neurolysin; domain 3	5l43A01

1S4BP 1I1IP 4KA8A 4KA7A 2O36A 4PUTA 2O3EA 4FXYP 5L43A 5L44A 1Y791
chains in the Genus database with same CATH superfamily

2H1JA 3CE2A 4KA8A 4KA7A 2O3EA 3SKSA 1I1IP 4PUTA 1KA4A 5L43A 3AHMA 2QR4A 4FXYP 3AHNA 3HQ2A 1Y791 1KA2A 1S4BP 3AHOA 2H1NA 1K9XA 3HOAA 5E3XA 2O36A 3DWCA 5L44A
chains in the Genus database with same CATH topology

2H1JA 4KA8A 3CE2A 4KA7A 2O3EA 3SKSA 1I1IP 4PUTA 1KA4A 5L43A 3AHMA 2QR4A 4FXYP 3AHNA 3HQ2A 1Y791 1KA2A 1S4BP 3AHOA 2H1NA 1K9XA 3HOAA 5E3XA 2O36A 3DWCA 5L44A
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1S4B P;  1I1I P;  4KA8 A;  4KA7 A;  2O36 A;  4PUT A;  2O3E A;  4FXY P;  5L43 A;  5L44 A;  1Y79 1; 
#chains in the Genus database with same CATH topology
 2H1J A;  3CE2 A;  4KA8 A;  4KA7 A;  2O3E A;  3SKS A;  1I1I P;  4PUT A;  1KA4 A;  5L43 A;  3AHM A;  2QR4 A;  4FXY P;  3AHN A;  3HQ2 A;  1Y79 1;  1KA2 A;  1S4B P;  3AHO A;  2H1N A;  1K9X A;  3HOA A;  5E3X A;  2O36 A;  3DWC A;  5L44 A; 
#chains in the Genus database with same CATH homology
 2H1J A;  4KA8 A;  3CE2 A;  4KA7 A;  2O3E A;  3SKS A;  1I1I P;  4PUT A;  1KA4 A;  5L43 A;  3AHM A;  2QR4 A;  4FXY P;  3AHN A;  3HQ2 A;  1Y79 1;  1KA2 A;  1S4B P;  3AHO A;  2H1N A;  1K9X A;  3HOA A;  5E3X A;  2O36 A;  3DWC A;  5L44 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5L43A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization