4MCBA

H.influenzae trmd in complex with n-(4-{[(1h-imidazol-2-ylmethyl)amino]methyl}benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
Knots found
sequence length
219
structure length
205
Chain Sequence
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGLLDCPHYTRPEVLEGLTVPPVLMSHHEEIRKWRLKQSLQRTWLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 50
structure length 205
sequence length 219
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mcbA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mcbA01
4YQTA 2V3KA 1OY5A 3DCMX 2CX8A 5GMCA 5FAIA 4YQKA 3QUVA 3AXZA 1Z85A 1UAJA 3KTYA 1VHKA 4RG1A 3AIAA 3E5YA 4YQJA 4CNGA 4JALA 3BBEA 1MXIA 4YQAA 2HA8A 1VH0A 3N4JA 4YQPA 3BBDA 5GMBA 4YPZA 5D9FA 1ZJRA 2V3JA 3KNUA 4PZKA 4X3MA 1UAKA 4YQLA 4YQ4A 1UALA 3GYQA 1J85A 4YQQA 4YQNA 1V6ZA 2YY8A 3IEFA 1X7OA 3OIIA 3ILKA 4YQBA 2I6DA 4YPWA 1NS5A 1VHYA 4YVKA 2EGVA 4YQ9A 4KDZA 4CNEA 3OIJA 1P9PA 4YQRA 4MCBA 4IG6A 2QWVA 4YQ3A 1X7PA 4CNFA 4XBOA 1NXZA 4YQ7A 4YQ2A 3NK6A 4YQDA 3KW2A 3BBHA 3L8UA 4YVGA 4YQOA 3N4KA 4YQCA 4YQ0A 3OINA 1TO0A 4YVHA 4JAKA 1GZ0A 2QMMA 3AI9X 4YQ8A 4YQ1A 4YVJA 4MCDA 4YQIA 4YQ6A 1IPAA 2EGWA 4YPYA 4FAKA 3ONPA 3KY7A 1O6DA 5GM8A 4H3YA 1UAMA 4CNDA 3IC6A 5CO4A 4YQGA 4X3LA 2Z0YA 4YVIA 1K3RA 4MCCA 4KGNA 2O3AA 3O7BA 4L69A 4E8BA 4H3ZA 1V2XA 4YQSA 3NK7A 4J3CA 4YPXA 4YQ5A
chains in the Genus database with same CATH superfamily
4YQTA 3G1CA 1JHGA 3WRPA 2V3KA 1OY5A 3DCMX 1WRSR 1MI7R 2CX8A 5GMCA 3FRWA 5FAIA 4YQKA 3KORA 3QUVA 3AXZA 1TROA 1Z85A 1UAJA 3KTYA 1VHKA 4RG1A 3AIAA 3E5YA 4JWFA 4YQJA 1WRTR 4CNGA 4JALA 3BBEA 1MXIA 4YQAA 2HA8A 1VH0A 1ZT9A 3N4JA 4YQPA 1TRRA 3BBDA 5GMBA 4YPZA 5D9FA 1ZJRA 2V3JA 3KNUA 4PZKA 4X3MA 1UAKA 4YQLA 4YQ4A 1UALA 3GYQA 1J85A 4YQQA 4JWHA 4YQNA 1V6ZA 2YY8A 3IEFA 3SSXN 1X7OA 3OIIA 3ILKA 4YQBA 2I6DA 2OZ9R 4FMWA 4YPWA 1NS5A 1VHYA 4YVKA 2EGVA 1CO0A 4YQ9A 1RCSA 4KDZA 4CNEA 3OIJA 1P9PA 4JWJA 3SSWN 4YQRA 1WRPR 4MCBA 4IG6A 2QWVA 4YQ3A 1X7PA 4CNFA 4XBOA 1NXZA 4YQ7A 4YQ2A 3NK6A 4YQDA 3KW2A 3BBHA 3L8UA 4YVGA 4YQOA 2XDIA 3N4KA 4YQCA 4YQ0A 3OINA 1TO0A 4YVHA 4JAKA 1GZ0A 4JWGA 2QMMA 3AI9X 4YQ8A 4YQ1A 4YVJA 4MCDA 4YQIA 4YQ6A 1IPAA 2EGWA 4YPYA 4FAKA 3ONPA 3KY7A 1O6DA 5GM8A 4H3YA 1UAMA 4CNDA 3IC6A 5CO4A 4YQGA 4X3LA 2Z0YA 4YVIA 1K3RA 4MCCA 4KGNA 2O3AA 3O7BA 4L69A 4E8BA 4H3ZA 1V2XA 4YQSA 3NK7A 4J3CA 4YPXA 4YQ5A
chains in the Genus database with same CATH topology
4YQTA 2V3KA 1OY5A 3DCMX 2CX8A 5GMCA 5FAIA 4YQKA 3QUVA 3AXZA 1Z85A 1UAJA 3KTYA 1VHKA 4RG1A 3AIAA 3E5YA 4JWFA 4YQJA 4CNGA 4JALA 3BBEA 1MXIA 4YQAA 2HA8A 1VH0A 3N4JA 4YQPA 3BBDA 5GMBA 4YPZA 5D9FA 1ZJRA 2V3JA 3KNUA 4PZKA 4X3MA 1UAKA 4YQLA 4YQ4A 1UALA 3GYQA 1J85A 4YQQA 4JWHA 4YQNA 1V6ZA 2YY8A 3IEFA 1X7OA 3OIIA 3ILKA 4YQBA 2I6DA 4FMWA 4YPWA 1NS5A 1VHYA 4YVKA 2EGVA 4YQ9A 4KDZA 4CNEA 3OIJA 1P9PA 4JWJA 4YQRA 4MCBA 4IG6A 2QWVA 4YQ3A 1X7PA 4CNFA 4XBOA 1NXZA 4YQ7A 4YQ2A 3NK6A 4YQDA 3KW2A 3BBHA 3L8UA 4YVGA 4YQOA 3N4KA 4YQCA 4YQ0A 3OINA 1TO0A 4YVHA 4JAKA 1GZ0A 4JWGA 2QMMA 3AI9X 4YQ8A 4YQ1A 4YVJA 4MCDA 4YQIA 4YQ6A 1IPAA 2EGWA 4YPYA 4FAKA 3ONPA 3KY7A 1O6DA 5GM8A 4H3YA 1UAMA 4CNDA 3IC6A 5CO4A 4YQGA 4X3LA 2Z0YA 4YVIA 1K3RA 4MCCA 4KGNA 2O3AA 3O7BA 4L69A 4E8BA 4H3ZA 1V2XA 4YQSA 3NK7A 4J3CA 4YPXA 4YQ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YQT A;  2V3K A;  1OY5 A;  3DCM X;  2CX8 A;  5GMC A;  5FAI A;  4YQK A;  3QUV A;  3AXZ A;  1Z85 A;  1UAJ A;  3KTY A;  1VHK A;  4RG1 A;  3AIA A;  3E5Y A;  4YQJ A;  4CNG A;  4JAL A;  3BBE A;  1MXI A;  4YQA A;  2HA8 A;  1VH0 A;  3N4J A;  4YQP A;  3BBD A;  5GMB A;  4YPZ A;  5D9F A;  1ZJR A;  2V3J A;  3KNU A;  4PZK A;  4X3M A;  1UAK A;  4YQL A;  4YQ4 A;  1UAL A;  3GYQ A;  1J85 A;  4YQQ A;  4YQN A;  1V6Z A;  2YY8 A;  3IEF A;  1X7O A;  3OII A;  3ILK A;  4YQB A;  2I6D A;  4YPW A;  1NS5 A;  1VHY A;  4YVK A;  2EGV A;  4YQ9 A;  4KDZ A;  4CNE A;  3OIJ A;  1P9P A;  4YQR A;  4MCB A;  4IG6 A;  2QWV A;  4YQ3 A;  1X7P A;  4CNF A;  4XBO A;  1NXZ A;  4YQ7 A;  4YQ2 A;  3NK6 A;  4YQD A;  3KW2 A;  3BBH A;  3L8U A;  4YVG A;  4YQO A;  3N4K A;  4YQC A;  4YQ0 A;  3OIN A;  1TO0 A;  4YVH A;  4JAK A;  1GZ0 A;  2QMM A;  3AI9 X;  4YQ8 A;  4YQ1 A;  4YVJ A;  4MCD A;  4YQI A;  4YQ6 A;  1IPA A;  2EGW A;  4YPY A;  4FAK A;  3ONP A;  3KY7 A;  1O6D A;  5GM8 A;  4H3Y A;  1UAM A;  4CND A;  3IC6 A;  5CO4 A;  4YQG A;  4X3L A;  2Z0Y A;  4YVI A;  1K3R A;  4MCC A;  4KGN A;  2O3A A;  3O7B A;  4L69 A;  4E8B A;  4H3Z A;  1V2X A;  4YQS A;  3NK7 A;  4J3C A;  4YPX A;  4YQ5 A; 
#chains in the Genus database with same CATH topology
 4YQT A;  3G1C A;  1JHG A;  3WRP A;  2V3K A;  1OY5 A;  3DCM X;  1WRS R;  1MI7 R;  2CX8 A;  5GMC A;  3FRW A;  5FAI A;  4YQK A;  3KOR A;  3QUV A;  3AXZ A;  1TRO A;  1Z85 A;  1UAJ A;  3KTY A;  1VHK A;  4RG1 A;  3AIA A;  3E5Y A;  4JWF A;  4YQJ A;  1WRT R;  4CNG A;  4JAL A;  3BBE A;  1MXI A;  4YQA A;  2HA8 A;  1VH0 A;  1ZT9 A;  3N4J A;  4YQP A;  1TRR A;  3BBD A;  5GMB A;  4YPZ A;  5D9F A;  1ZJR A;  2V3J A;  3KNU A;  4PZK A;  4X3M A;  1UAK A;  4YQL A;  4YQ4 A;  1UAL A;  3GYQ A;  1J85 A;  4YQQ A;  4JWH A;  4YQN A;  1V6Z A;  2YY8 A;  3IEF A;  3SSX N;  1X7O A;  3OII A;  3ILK A;  4YQB A;  2I6D A;  2OZ9 R;  4FMW A;  4YPW A;  1NS5 A;  1VHY A;  4YVK A;  2EGV A;  1CO0 A;  4YQ9 A;  1RCS A;  4KDZ A;  4CNE A;  3OIJ A;  1P9P A;  4JWJ A;  3SSW N;  4YQR A;  1WRP R;  4MCB A;  4IG6 A;  2QWV A;  4YQ3 A;  1X7P A;  4CNF A;  4XBO A;  1NXZ A;  4YQ7 A;  4YQ2 A;  3NK6 A;  4YQD A;  3KW2 A;  3BBH A;  3L8U A;  4YVG A;  4YQO A;  2XDI A;  3N4K A;  4YQC A;  4YQ0 A;  3OIN A;  1TO0 A;  4YVH A;  4JAK A;  1GZ0 A;  4JWG A;  2QMM A;  3AI9 X;  4YQ8 A;  4YQ1 A;  4YVJ A;  4MCD A;  4YQI A;  4YQ6 A;  1IPA A;  2EGW A;  4YPY A;  4FAK A;  3ONP A;  3KY7 A;  1O6D A;  5GM8 A;  4H3Y A;  1UAM A;  4CND A;  3IC6 A;  5CO4 A;  4YQG A;  4X3L A;  2Z0Y A;  4YVI A;  1K3R A;  4MCC A;  4KGN A;  2O3A A;  3O7B A;  4L69 A;  4E8B A;  4H3Z A;  1V2X A;  4YQS A;  3NK7 A;  4J3C A;  4YPX A;  4YQ5 A; 
#chains in the Genus database with same CATH homology
 4YQT A;  2V3K A;  1OY5 A;  3DCM X;  2CX8 A;  5GMC A;  5FAI A;  4YQK A;  3QUV A;  3AXZ A;  1Z85 A;  1UAJ A;  3KTY A;  1VHK A;  4RG1 A;  3AIA A;  3E5Y A;  4JWF A;  4YQJ A;  4CNG A;  4JAL A;  3BBE A;  1MXI A;  4YQA A;  2HA8 A;  1VH0 A;  3N4J A;  4YQP A;  3BBD A;  5GMB A;  4YPZ A;  5D9F A;  1ZJR A;  2V3J A;  3KNU A;  4PZK A;  4X3M A;  1UAK A;  4YQL A;  4YQ4 A;  1UAL A;  3GYQ A;  1J85 A;  4YQQ A;  4JWH A;  4YQN A;  1V6Z A;  2YY8 A;  3IEF A;  1X7O A;  3OII A;  3ILK A;  4YQB A;  2I6D A;  4FMW A;  4YPW A;  1NS5 A;  1VHY A;  4YVK A;  2EGV A;  4YQ9 A;  4KDZ A;  4CNE A;  3OIJ A;  1P9P A;  4JWJ A;  4YQR A;  4MCB A;  4IG6 A;  2QWV A;  4YQ3 A;  1X7P A;  4CNF A;  4XBO A;  1NXZ A;  4YQ7 A;  4YQ2 A;  3NK6 A;  4YQD A;  3KW2 A;  3BBH A;  3L8U A;  4YVG A;  4YQO A;  3N4K A;  4YQC A;  4YQ0 A;  3OIN A;  1TO0 A;  4YVH A;  4JAK A;  1GZ0 A;  4JWG A;  2QMM A;  3AI9 X;  4YQ8 A;  4YQ1 A;  4YVJ A;  4MCD A;  4YQI A;  4YQ6 A;  1IPA A;  2EGW A;  4YPY A;  4FAK A;  3ONP A;  3KY7 A;  1O6D A;  5GM8 A;  4H3Y A;  1UAM A;  4CND A;  3IC6 A;  5CO4 A;  4YQG A;  4X3L A;  2Z0Y A;  4YVI A;  1K3R A;  4MCC A;  4KGN A;  2O3A A;  3O7B A;  4L69 A;  4E8B A;  4H3Z A;  1V2X A;  4YQS A;  3NK7 A;  4J3C A;  4YPX A;  4YQ5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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