4MCDA

Hintrmd in complex with 5-phenylthieno[2,3-d]pyrimidin-4(3h)-one
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
Knots found
sequence length
246
structure length
237
Chain Sequence
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae rd kw20
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 69
structure length 237
sequence length 246
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mcdA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mcdA01
4X3MA 3KNUA 1V6ZA 5GMBA 4MCCA 5D9FA 2EGWA 3QUVA 4YVHA 4IG6A 1P9PA 5FAIA 4YQLA 4YQJA 4YQTA 4YQ8A 4YPZA 2I6DA 1X7PA 4JALA 4KDZA 3DCMX 3OIJA 4E8BA 4CNGA 4CNDA 1NS5A 4YPWA 2YY8A 3NK6A 1X7OA 4H3YA 4YQSA 4JAKA 2O3AA 1GZ0A 1UAKA 4YQ6A 4YVJA 1UAMA 2V3KA 4YVKA 4YPYA 4YQIA 4YQ5A 1IPAA 4YQGA 1OY5A 3BBEA 5CO4A 4J3CA 4X3LA 3OIIA 4YQ7A 3IEFA 3L8UA 4YQDA 4XBOA 4YQQA 4MCDA 4YQ1A 4YQ4A 2V3JA 5GM8A 4YQAA 3ONPA 3BBDA 2QWVA 4PZKA 3AIAA 4YQ2A 3NK7A 4YQ3A 1ZJRA 3O7BA 4CNEA 4YQOA 1J85A 5GMCA 1K3RA 4KGNA 3KY7A 3KTYA 1NXZA 1O6DA 3N4JA 2EGVA 4YQCA 3ILKA 4YQPA 1VHKA 3AI9X 4YQNA 2Z0YA 3BBHA 1UALA 1TO0A 4FAKA 4L69A 1MXIA 2CX8A 4YQKA 4YQRA 2QMMA 4YQ9A 2HA8A 4YQ0A 1VHYA 3AXZA 1V2XA 3N4KA 3OINA 4YQBA 4MCBA 3KW2A 4RG1A 4H3ZA 1VH0A 1Z85A 1UAJA 3GYQA 4YPXA 4YVGA 4CNFA 3IC6A 3E5YA 4YVIA
chains in the Genus database with same CATH superfamily
4X3MA 2XDIA 3KNUA 1V6ZA 5GMBA 1ZT9A 4MCCA 5D9FA 2EGWA 3QUVA 4YVHA 4IG6A 1P9PA 1WRPR 5FAIA 4YQLA 1WRTR 4YQJA 4YQTA 3SSXN 4YQ8A 4YPZA 2I6DA 1X7PA 3WRPA 4JALA 4KDZA 3DCMX 4JWGA 3OIJA 4E8BA 4CNGA 4CNDA 1NS5A 4YPWA 2YY8A 3NK6A 1X7OA 4H3YA 4YQSA 4JAKA 2O3AA 1GZ0A 1UAKA 4YQ6A 4FMWA 4YVJA 1UAMA 2V3KA 4YVKA 1RCSA 4YPYA 4YQIA 4YQ5A 1IPAA 4YQGA 1OY5A 3BBEA 5CO4A 4JWFA 4J3CA 4X3LA 3OIIA 4YQ7A 3IEFA 3L8UA 4YQDA 4XBOA 4YQQA 4MCDA 1WRSR 4YQ1A 1TROA 4YQ4A 2V3JA 5GM8A 4YQAA 4JWHA 3ONPA 2OZ9R 3BBDA 2QWVA 4PZKA 3AIAA 1MI7R 4YQ2A 3NK7A 4YQ3A 1ZJRA 3O7BA 4CNEA 4YQOA 3KORA 1J85A 5GMCA 1K3RA 4KGNA 3KY7A 1CO0A 3KTYA 1NXZA 1O6DA 3N4JA 2EGVA 4YQCA 3ILKA 4YQPA 1VHKA 3AI9X 4YQNA 2Z0YA 3BBHA 1UALA 1TO0A 4FAKA 4L69A 1MXIA 2CX8A 4YQKA 4YQRA 2QMMA 4YQ9A 3G1CA 3SSWN 2HA8A 4YQ0A 1VHYA 4JWJA 3FRWA 3AXZA 1V2XA 3N4KA 3OINA 4YQBA 4MCBA 3KW2A 4RG1A 4H3ZA 1VH0A 1Z85A 1JHGA 1UAJA 3GYQA 4YPXA 4YVGA 1TRRA 4CNFA 3IC6A 3E5YA 4YVIA
chains in the Genus database with same CATH topology
4X3MA 3KNUA 1V6ZA 5GMBA 4MCCA 5D9FA 2EGWA 3QUVA 4YVHA 4IG6A 1P9PA 5FAIA 4YQLA 4YQJA 4YQTA 4YQ8A 4YPZA 2I6DA 1X7PA 4JALA 4KDZA 3DCMX 4JWGA 3OIJA 4E8BA 4CNGA 4CNDA 1NS5A 4YPWA 2YY8A 3NK6A 1X7OA 4H3YA 4YQSA 4JAKA 2O3AA 1GZ0A 1UAKA 4YQ6A 4FMWA 4YVJA 1UAMA 2V3KA 4YVKA 4YPYA 4YQIA 4YQ5A 1IPAA 4YQGA 1OY5A 3BBEA 5CO4A 4JWFA 4J3CA 4X3LA 3OIIA 4YQ7A 3IEFA 3L8UA 4YQDA 4XBOA 4YQQA 4MCDA 4YQ1A 4YQ4A 2V3JA 5GM8A 4YQAA 4JWHA 3ONPA 3BBDA 2QWVA 4PZKA 3AIAA 4YQ2A 3NK7A 4YQ3A 1ZJRA 3O7BA 4CNEA 4YQOA 1J85A 5GMCA 1K3RA 4KGNA 3KY7A 3KTYA 1NXZA 1O6DA 3N4JA 2EGVA 4YQCA 3ILKA 4YQPA 1VHKA 3AI9X 4YQNA 2Z0YA 3BBHA 1UALA 1TO0A 4FAKA 4L69A 1MXIA 2CX8A 4YQKA 4YQRA 2QMMA 4YQ9A 2HA8A 4YQ0A 1VHYA 4JWJA 3AXZA 1V2XA 3N4KA 3OINA 4YQBA 4MCBA 3KW2A 4RG1A 4H3ZA 1VH0A 1Z85A 1UAJA 3GYQA 4YPXA 4YVGA 4CNFA 3IC6A 3E5YA 4YVIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X3M A;  3KNU A;  1V6Z A;  5GMB A;  4MCC A;  5D9F A;  2EGW A;  3QUV A;  4YVH A;  4IG6 A;  1P9P A;  5FAI A;  4YQL A;  4YQJ A;  4YQT A;  4YQ8 A;  4YPZ A;  2I6D A;  1X7P A;  4JAL A;  4KDZ A;  3DCM X;  3OIJ A;  4E8B A;  4CNG A;  4CND A;  1NS5 A;  4YPW A;  2YY8 A;  3NK6 A;  1X7O A;  4H3Y A;  4YQS A;  4JAK A;  2O3A A;  1GZ0 A;  1UAK A;  4YQ6 A;  4YVJ A;  1UAM A;  2V3K A;  4YVK A;  4YPY A;  4YQI A;  4YQ5 A;  1IPA A;  4YQG A;  1OY5 A;  3BBE A;  5CO4 A;  4J3C A;  4X3L A;  3OII A;  4YQ7 A;  3IEF A;  3L8U A;  4YQD A;  4XBO A;  4YQQ A;  4MCD A;  4YQ1 A;  4YQ4 A;  2V3J A;  5GM8 A;  4YQA A;  3ONP A;  3BBD A;  2QWV A;  4PZK A;  3AIA A;  4YQ2 A;  3NK7 A;  4YQ3 A;  1ZJR A;  3O7B A;  4CNE A;  4YQO A;  1J85 A;  5GMC A;  1K3R A;  4KGN A;  3KY7 A;  3KTY A;  1NXZ A;  1O6D A;  3N4J A;  2EGV A;  4YQC A;  3ILK A;  4YQP A;  1VHK A;  3AI9 X;  4YQN A;  2Z0Y A;  3BBH A;  1UAL A;  1TO0 A;  4FAK A;  4L69 A;  1MXI A;  2CX8 A;  4YQK A;  4YQR A;  2QMM A;  4YQ9 A;  2HA8 A;  4YQ0 A;  1VHY A;  3AXZ A;  1V2X A;  3N4K A;  3OIN A;  4YQB A;  4MCB A;  3KW2 A;  4RG1 A;  4H3Z A;  1VH0 A;  1Z85 A;  1UAJ A;  3GYQ A;  4YPX A;  4YVG A;  4CNF A;  3IC6 A;  3E5Y A;  4YVI A; 
#chains in the Genus database with same CATH topology
 4X3M A;  2XDI A;  3KNU A;  1V6Z A;  5GMB A;  1ZT9 A;  4MCC A;  5D9F A;  2EGW A;  3QUV A;  4YVH A;  4IG6 A;  1P9P A;  1WRP R;  5FAI A;  4YQL A;  1WRT R;  4YQJ A;  4YQT A;  3SSX N;  4YQ8 A;  4YPZ A;  2I6D A;  1X7P A;  3WRP A;  4JAL A;  4KDZ A;  3DCM X;  4JWG A;  3OIJ A;  4E8B A;  4CNG A;  4CND A;  1NS5 A;  4YPW A;  2YY8 A;  3NK6 A;  1X7O A;  4H3Y A;  4YQS A;  4JAK A;  2O3A A;  1GZ0 A;  1UAK A;  4YQ6 A;  4FMW A;  4YVJ A;  1UAM A;  2V3K A;  4YVK A;  1RCS A;  4YPY A;  4YQI A;  4YQ5 A;  1IPA A;  4YQG A;  1OY5 A;  3BBE A;  5CO4 A;  4JWF A;  4J3C A;  4X3L A;  3OII A;  4YQ7 A;  3IEF A;  3L8U A;  4YQD A;  4XBO A;  4YQQ A;  4MCD A;  1WRS R;  4YQ1 A;  1TRO A;  4YQ4 A;  2V3J A;  5GM8 A;  4YQA A;  4JWH A;  3ONP A;  2OZ9 R;  3BBD A;  2QWV A;  4PZK A;  3AIA A;  1MI7 R;  4YQ2 A;  3NK7 A;  4YQ3 A;  1ZJR A;  3O7B A;  4CNE A;  4YQO A;  3KOR A;  1J85 A;  5GMC A;  1K3R A;  4KGN A;  3KY7 A;  1CO0 A;  3KTY A;  1NXZ A;  1O6D A;  3N4J A;  2EGV A;  4YQC A;  3ILK A;  4YQP A;  1VHK A;  3AI9 X;  4YQN A;  2Z0Y A;  3BBH A;  1UAL A;  1TO0 A;  4FAK A;  4L69 A;  1MXI A;  2CX8 A;  4YQK A;  4YQR A;  2QMM A;  4YQ9 A;  3G1C A;  3SSW N;  2HA8 A;  4YQ0 A;  1VHY A;  4JWJ A;  3FRW A;  3AXZ A;  1V2X A;  3N4K A;  3OIN A;  4YQB A;  4MCB A;  3KW2 A;  4RG1 A;  4H3Z A;  1VH0 A;  1Z85 A;  1JHG A;  1UAJ A;  3GYQ A;  4YPX A;  4YVG A;  1TRR A;  4CNF A;  3IC6 A;  3E5Y A;  4YVI A; 
#chains in the Genus database with same CATH homology
 4X3M A;  3KNU A;  1V6Z A;  5GMB A;  4MCC A;  5D9F A;  2EGW A;  3QUV A;  4YVH A;  4IG6 A;  1P9P A;  5FAI A;  4YQL A;  4YQJ A;  4YQT A;  4YQ8 A;  4YPZ A;  2I6D A;  1X7P A;  4JAL A;  4KDZ A;  3DCM X;  4JWG A;  3OIJ A;  4E8B A;  4CNG A;  4CND A;  1NS5 A;  4YPW A;  2YY8 A;  3NK6 A;  1X7O A;  4H3Y A;  4YQS A;  4JAK A;  2O3A A;  1GZ0 A;  1UAK A;  4YQ6 A;  4FMW A;  4YVJ A;  1UAM A;  2V3K A;  4YVK A;  4YPY A;  4YQI A;  4YQ5 A;  1IPA A;  4YQG A;  1OY5 A;  3BBE A;  5CO4 A;  4JWF A;  4J3C A;  4X3L A;  3OII A;  4YQ7 A;  3IEF A;  3L8U A;  4YQD A;  4XBO A;  4YQQ A;  4MCD A;  4YQ1 A;  4YQ4 A;  2V3J A;  5GM8 A;  4YQA A;  4JWH A;  3ONP A;  3BBD A;  2QWV A;  4PZK A;  3AIA A;  4YQ2 A;  3NK7 A;  4YQ3 A;  1ZJR A;  3O7B A;  4CNE A;  4YQO A;  1J85 A;  5GMC A;  1K3R A;  4KGN A;  3KY7 A;  3KTY A;  1NXZ A;  1O6D A;  3N4J A;  2EGV A;  4YQC A;  3ILK A;  4YQP A;  1VHK A;  3AI9 X;  4YQN A;  2Z0Y A;  3BBH A;  1UAL A;  1TO0 A;  4FAK A;  4L69 A;  1MXI A;  2CX8 A;  4YQK A;  4YQR A;  2QMM A;  4YQ9 A;  2HA8 A;  4YQ0 A;  1VHY A;  4JWJ A;  3AXZ A;  1V2X A;  3N4K A;  3OIN A;  4YQB A;  4MCB A;  3KW2 A;  4RG1 A;  4H3Z A;  1VH0 A;  1Z85 A;  1UAJ A;  3GYQ A;  4YPX A;  4YVG A;  4CNF A;  3IC6 A;  3E5Y A;  4YVI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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