4MCDA

Hintrmd in complex with 5-phenylthieno[2,3-d]pyrimidin-4(3h)-one
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
Knots found
sequence length
246
structure length
237
Chain Sequence
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae rd kw20
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 69
structure length 237
sequence length 246
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mcdA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mcdA01
2EGWA 3GYQA 1OY5A 1VH0A 4CNEA 3ILKA 4YVHA 1X7OA 1J85A 3N4KA 4YVIA 1UAKA 3NK6A 2EGVA 4H3ZA 1VHKA 4YQ9A 3KW2A 3OINA 4CNDA 4J3CA 4YPYA 3KNUA 4YPZA 4YQLA 5GMBA 2V3KA 2HA8A 4YPXA 3O7BA 3E5YA 1P9PA 4YVGA 5GM8A 3DCMX 1TO0A 3L8UA 4YPWA 4YQRA 2CX8A 4YQ5A 4YQ3A 3OIIA 4X3MA 4L69A 5FAIA 2I6DA 4YQ8A 4YQQA 4YQ2A 4YQ6A 1V2XA 3KY7A 2QWVA 4YQAA 4RG1A 4PZKA 5D9FA 3AI9X 5GMCA 1Z85A 4CNGA 1UALA 5CO4A 3OIJA 4YQOA 4YQ1A 1NS5A 4YQDA 4YQPA 2QMMA 4JALA 4KGNA 4YQKA 1VHYA 4YQIA 3IEFA 1GZ0A 4YQGA 1UAJA 3IC6A 1MXIA 4YQTA 1X7PA 2O3AA 1NXZA 4KDZA 4YVJA 4YQNA 4YQ4A 3AIAA 4XBOA 3ONPA 4FAKA 2V3JA 1ZJRA 4YQSA 2YY8A 3BBEA 4CNFA 4E8BA 3KTYA 4YQJA 4X3LA 4JAKA 3QUVA 2Z0YA 4MCBA 1IPAA 1UAMA 3AXZA 4YVKA 1O6DA 3NK7A 1K3RA 4YQ7A 4H3YA 4YQCA 3N4JA 4IG6A 4YQBA 4MCDA 4YQ0A 1V6ZA 4MCCA 3BBDA 3BBHA
chains in the Genus database with same CATH superfamily
2EGWA 3GYQA 1OY5A 1VH0A 4CNEA 4JWFA 3ILKA 4YVHA 1TROA 1X7OA 1ZT9A 1J85A 1RCSA 1JHGA 4YVIA 3N4KA 1UAKA 4JWHA 3NK6A 2EGVA 4H3ZA 1VHKA 4YQ9A 3SSXN 3KW2A 3OINA 1CO0A 4CNDA 4J3CA 4YPYA 3KNUA 4YPZA 4YQLA 5GMBA 2V3KA 2HA8A 4YPXA 3O7BA 3E5YA 1WRSR 1P9PA 4YVGA 5GM8A 3DCMX 4JWJA 3KORA 1TO0A 3L8UA 4YPWA 4YQRA 2CX8A 4YQ5A 4YQ3A 3OIIA 4X3MA 4L69A 5FAIA 2I6DA 4YQ8A 4YQQA 4YQ2A 3G1CA 4YQ6A 1V2XA 3KY7A 2QWVA 4YQAA 1WRPR 4RG1A 4PZKA 5D9FA 2XDIA 3AI9X 1Z85A 5GMCA 4CNGA 1UALA 5CO4A 3OIJA 4YQOA 4YQ1A 1MI7R 1NS5A 4YQDA 4YQPA 2QMMA 3WRPA 4JALA 4KGNA 4YQKA 1VHYA 4YQIA 3IEFA 1GZ0A 4YQGA 1UAJA 3IC6A 1MXIA 4YQTA 2OZ9R 3SSWN 1X7PA 2O3AA 1NXZA 4KDZA 4YVJA 4YQNA 1WRTR 4YQ4A 3AIAA 4XBOA 3ONPA 4FAKA 2V3JA 1ZJRA 4YQSA 1TRRA 2YY8A 3BBEA 4CNFA 4E8BA 3KTYA 4YQJA 4FMWA 4X3LA 4JAKA 3QUVA 2Z0YA 4MCBA 3FRWA 1UAMA 3AXZA 4YVKA 1IPAA 1O6DA 3NK7A 4JWGA 1K3RA 4YQ7A 4H3YA 4YQCA 3N4JA 4IG6A 4YQBA 4MCDA 4YQ0A 1V6ZA 4MCCA 3BBDA 3BBHA
chains in the Genus database with same CATH topology
2EGWA 3GYQA 1OY5A 1VH0A 4CNEA 4JWFA 3ILKA 4YVHA 1X7OA 1J85A 3N4KA 4YVIA 1UAKA 4JWHA 3NK6A 2EGVA 4H3ZA 1VHKA 4YQ9A 3KW2A 3OINA 4CNDA 4J3CA 4YPYA 3KNUA 4YPZA 4YQLA 5GMBA 2V3KA 2HA8A 4YPXA 3O7BA 3E5YA 1P9PA 4YVGA 5GM8A 3DCMX 4JWJA 1TO0A 3L8UA 4YPWA 4YQRA 2CX8A 4YQ5A 4YQ3A 3OIIA 4X3MA 4L69A 5FAIA 2I6DA 4YQ8A 4YQQA 4YQ2A 4YQ6A 1V2XA 3KY7A 2QWVA 4YQAA 4RG1A 4PZKA 5D9FA 3AI9X 5GMCA 1Z85A 4CNGA 1UALA 5CO4A 3OIJA 4YQOA 4YQ1A 1NS5A 4YQDA 4YQPA 2QMMA 4JALA 4KGNA 4YQKA 1VHYA 4YQIA 3IEFA 1GZ0A 4YQGA 1UAJA 3IC6A 1MXIA 4YQTA 1X7PA 2O3AA 1NXZA 4KDZA 4YVJA 4YQNA 4YQ4A 3AIAA 4XBOA 3ONPA 4FAKA 2V3JA 1ZJRA 4YQSA 2YY8A 3BBEA 4CNFA 4E8BA 3KTYA 4YQJA 4FMWA 4X3LA 4JAKA 3QUVA 2Z0YA 4MCBA 1IPAA 1UAMA 3AXZA 4YVKA 1O6DA 3NK7A 4JWGA 1K3RA 4YQ7A 4H3YA 4YQCA 3N4JA 4IG6A 4YQBA 4MCDA 4YQ0A 1V6ZA 4MCCA 3BBDA 3BBHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EGW A;  3GYQ A;  1OY5 A;  1VH0 A;  4CNE A;  3ILK A;  4YVH A;  1X7O A;  1J85 A;  3N4K A;  4YVI A;  1UAK A;  3NK6 A;  2EGV A;  4H3Z A;  1VHK A;  4YQ9 A;  3KW2 A;  3OIN A;  4CND A;  4J3C A;  4YPY A;  3KNU A;  4YPZ A;  4YQL A;  5GMB A;  2V3K A;  2HA8 A;  4YPX A;  3O7B A;  3E5Y A;  1P9P A;  4YVG A;  5GM8 A;  3DCM X;  1TO0 A;  3L8U A;  4YPW A;  4YQR A;  2CX8 A;  4YQ5 A;  4YQ3 A;  3OII A;  4X3M A;  4L69 A;  5FAI A;  2I6D A;  4YQ8 A;  4YQQ A;  4YQ2 A;  4YQ6 A;  1V2X A;  3KY7 A;  2QWV A;  4YQA A;  4RG1 A;  4PZK A;  5D9F A;  3AI9 X;  5GMC A;  1Z85 A;  4CNG A;  1UAL A;  5CO4 A;  3OIJ A;  4YQO A;  4YQ1 A;  1NS5 A;  4YQD A;  4YQP A;  2QMM A;  4JAL A;  4KGN A;  4YQK A;  1VHY A;  4YQI A;  3IEF A;  1GZ0 A;  4YQG A;  1UAJ A;  3IC6 A;  1MXI A;  4YQT A;  1X7P A;  2O3A A;  1NXZ A;  4KDZ A;  4YVJ A;  4YQN A;  4YQ4 A;  3AIA A;  4XBO A;  3ONP A;  4FAK A;  2V3J A;  1ZJR A;  4YQS A;  2YY8 A;  3BBE A;  4CNF A;  4E8B A;  3KTY A;  4YQJ A;  4X3L A;  4JAK A;  3QUV A;  2Z0Y A;  4MCB A;  1IPA A;  1UAM A;  3AXZ A;  4YVK A;  1O6D A;  3NK7 A;  1K3R A;  4YQ7 A;  4H3Y A;  4YQC A;  3N4J A;  4IG6 A;  4YQB A;  4MCD A;  4YQ0 A;  1V6Z A;  4MCC A;  3BBD A;  3BBH A; 
#chains in the Genus database with same CATH topology
 2EGW A;  3GYQ A;  1OY5 A;  1VH0 A;  4CNE A;  4JWF A;  3ILK A;  4YVH A;  1TRO A;  1X7O A;  1ZT9 A;  1J85 A;  1RCS A;  1JHG A;  4YVI A;  3N4K A;  1UAK A;  4JWH A;  3NK6 A;  2EGV A;  4H3Z A;  1VHK A;  4YQ9 A;  3SSX N;  3KW2 A;  3OIN A;  1CO0 A;  4CND A;  4J3C A;  4YPY A;  3KNU A;  4YPZ A;  4YQL A;  5GMB A;  2V3K A;  2HA8 A;  4YPX A;  3O7B A;  3E5Y A;  1WRS R;  1P9P A;  4YVG A;  5GM8 A;  3DCM X;  4JWJ A;  3KOR A;  1TO0 A;  3L8U A;  4YPW A;  4YQR A;  2CX8 A;  4YQ5 A;  4YQ3 A;  3OII A;  4X3M A;  4L69 A;  5FAI A;  2I6D A;  4YQ8 A;  4YQQ A;  4YQ2 A;  3G1C A;  4YQ6 A;  1V2X A;  3KY7 A;  2QWV A;  4YQA A;  1WRP R;  4RG1 A;  4PZK A;  5D9F A;  2XDI A;  3AI9 X;  1Z85 A;  5GMC A;  4CNG A;  1UAL A;  5CO4 A;  3OIJ A;  4YQO A;  4YQ1 A;  1MI7 R;  1NS5 A;  4YQD A;  4YQP A;  2QMM A;  3WRP A;  4JAL A;  4KGN A;  4YQK A;  1VHY A;  4YQI A;  3IEF A;  1GZ0 A;  4YQG A;  1UAJ A;  3IC6 A;  1MXI A;  4YQT A;  2OZ9 R;  3SSW N;  1X7P A;  2O3A A;  1NXZ A;  4KDZ A;  4YVJ A;  4YQN A;  1WRT R;  4YQ4 A;  3AIA A;  4XBO A;  3ONP A;  4FAK A;  2V3J A;  1ZJR A;  4YQS A;  1TRR A;  2YY8 A;  3BBE A;  4CNF A;  4E8B A;  3KTY A;  4YQJ A;  4FMW A;  4X3L A;  4JAK A;  3QUV A;  2Z0Y A;  4MCB A;  3FRW A;  1UAM A;  3AXZ A;  4YVK A;  1IPA A;  1O6D A;  3NK7 A;  4JWG A;  1K3R A;  4YQ7 A;  4H3Y A;  4YQC A;  3N4J A;  4IG6 A;  4YQB A;  4MCD A;  4YQ0 A;  1V6Z A;  4MCC A;  3BBD A;  3BBH A; 
#chains in the Genus database with same CATH homology
 2EGW A;  3GYQ A;  1OY5 A;  1VH0 A;  4CNE A;  4JWF A;  3ILK A;  4YVH A;  1X7O A;  1J85 A;  3N4K A;  4YVI A;  1UAK A;  4JWH A;  3NK6 A;  2EGV A;  4H3Z A;  1VHK A;  4YQ9 A;  3KW2 A;  3OIN A;  4CND A;  4J3C A;  4YPY A;  3KNU A;  4YPZ A;  4YQL A;  5GMB A;  2V3K A;  2HA8 A;  4YPX A;  3O7B A;  3E5Y A;  1P9P A;  4YVG A;  5GM8 A;  3DCM X;  4JWJ A;  1TO0 A;  3L8U A;  4YPW A;  4YQR A;  2CX8 A;  4YQ5 A;  4YQ3 A;  3OII A;  4X3M A;  4L69 A;  5FAI A;  2I6D A;  4YQ8 A;  4YQQ A;  4YQ2 A;  4YQ6 A;  1V2X A;  3KY7 A;  2QWV A;  4YQA A;  4RG1 A;  4PZK A;  5D9F A;  3AI9 X;  5GMC A;  1Z85 A;  4CNG A;  1UAL A;  5CO4 A;  3OIJ A;  4YQO A;  4YQ1 A;  1NS5 A;  4YQD A;  4YQP A;  2QMM A;  4JAL A;  4KGN A;  4YQK A;  1VHY A;  4YQI A;  3IEF A;  1GZ0 A;  4YQG A;  1UAJ A;  3IC6 A;  1MXI A;  4YQT A;  1X7P A;  2O3A A;  1NXZ A;  4KDZ A;  4YVJ A;  4YQN A;  4YQ4 A;  3AIA A;  4XBO A;  3ONP A;  4FAK A;  2V3J A;  1ZJR A;  4YQS A;  2YY8 A;  3BBE A;  4CNF A;  4E8B A;  3KTY A;  4YQJ A;  4FMW A;  4X3L A;  4JAK A;  3QUV A;  2Z0Y A;  4MCB A;  1IPA A;  1UAM A;  3AXZ A;  4YVK A;  1O6D A;  3NK7 A;  4JWG A;  1K3R A;  4YQ7 A;  4H3Y A;  4YQC A;  3N4J A;  4IG6 A;  4YQB A;  4MCD A;  4YQ0 A;  1V6Z A;  4MCC A;  3BBD A;  3BBH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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