4YPXA

Crystal structure of trmd, a m1g37 trna methyltransferase with sam-competitive compounds
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
Knots found
sequence length
249
structure length
239
Chain Sequence
RGSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds
rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd)
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 74
structure length 239
sequence length 249
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4ypxA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4ypxA01
4YQ6A 4YQ4A 4H3ZA 4YQIA 4H3YA 3ILKA 3AXZA 2EGVA 2YY8A 4X3MA 4YQ5A 4YQAA 4YVJA 3E5YA 3OINA 4PZKA 3N4KA 1ZJRA 4YVGA 4YQTA 2QWVA 3KY7A 4KDZA 3QUVA 4YQOA 4YQPA 2HA8A 2V3JA 5FAIA 4YQ3A 3IC6A 3GYQA 5CO4A 2CX8A 2EGWA 3BBEA 4J3CA 1NS5A 3KTYA 4KGNA 4CNDA 4YQ9A 4YQ0A 1GZ0A 1UAJA 3N4JA 1Z85A 4JAKA 1VHYA 4RG1A 4E8BA 1VHKA 1OY5A 4X3LA 1NXZA 4YVKA 4MCBA 3BBDA 4YQQA 1O6DA 3AI9X 4FAKA 3AIAA 4YQ7A 1V6ZA 4YQGA 2Z0YA 3IEFA 4YQLA 4L69A 4YQRA 3O7BA 4YQCA 2V3KA 1MXIA 1X7OA 4YQSA 4YVIA 1V2XA 4YQKA 1TO0A 4YPXA 5GMBA 4IG6A 4YQBA 1J85A 4YQ8A 4YQDA 4YQ2A 3L8UA 4YVHA 4YPZA 4CNGA 1P9PA 2O3AA 3NK6A 3NK7A 4YQJA 5D9FA 3DCMX 3OIIA 1VH0A 4YQ1A 1K3RA 2I6DA 3KNUA 4CNFA 3BBHA 3OIJA 1UAMA 3ONPA 4YPWA 3KW2A 4YQNA 4MCCA 1UALA 5GMCA 2QMMA 1X7PA 4YPYA 4XBOA 1UAKA 4JALA 5GM8A 4MCDA 4CNEA 1IPAA
chains in the Genus database with same CATH superfamily
4YQ6A 4YQ4A 4H3ZA 4YQIA 4H3YA 1JHGA 4JWHA 3ILKA 3AXZA 2EGVA 2YY8A 4X3MA 4YQ5A 4YQAA 4YVJA 3E5YA 3OINA 4PZKA 3N4KA 1ZJRA 1MI7R 4YVGA 4YQTA 2QWVA 3KY7A 4JWGA 4KDZA 3QUVA 4YQOA 4YQPA 2HA8A 2V3JA 5FAIA 4YQ3A 3IC6A 3GYQA 5CO4A 2CX8A 2EGWA 3BBEA 4J3CA 1NS5A 3KTYA 4KGNA 4CNDA 4YQ9A 4YQ0A 1TRRA 1GZ0A 1UAJA 3N4JA 1Z85A 4JAKA 1VHYA 4RG1A 4E8BA 1VHKA 1OY5A 4X3LA 1NXZA 4YVKA 2XDIA 4MCBA 3BBDA 4YQQA 1O6DA 3AI9X 4FAKA 3AIAA 4YQ7A 1WRPR 1V6ZA 4JWFA 4YQGA 2Z0YA 3IEFA 4YQLA 4L69A 4YQRA 3O7BA 4YQCA 2V3KA 1TROA 1MXIA 1X7OA 4YQSA 4YVIA 3SSWN 1V2XA 1WRTR 3FRWA 4YQKA 1TO0A 4YPXA 5GMBA 4IG6A 4YQBA 1J85A 1ZT9A 4YQ8A 4YQDA 4YQ2A 3L8UA 4YVHA 4YPZA 4CNGA 3G1CA 1P9PA 2O3AA 3NK6A 3NK7A 4YQJA 3SSXN 5D9FA 3DCMX 3OIIA 1VH0A 4FMWA 4YQ1A 1K3RA 2I6DA 3KNUA 4CNFA 3BBHA 3OIJA 1UAMA 3ONPA 3KORA 4YPWA 3KW2A 4YQNA 1CO0A 4MCCA 1UALA 5GMCA 1RCSA 2QMMA 1X7PA 4YPYA 4XBOA 3WRPA 1UAKA 4JALA 4JWJA 1WRSR 5GM8A 4MCDA 2OZ9R 4CNEA 1IPAA
chains in the Genus database with same CATH topology
4YQ6A 4YQ4A 4H3ZA 4YQIA 4H3YA 4JWHA 3ILKA 3AXZA 2EGVA 2YY8A 4X3MA 4YQ5A 4YQAA 4YVJA 3E5YA 3OINA 4PZKA 3N4KA 1ZJRA 4YVGA 4YQTA 2QWVA 3KY7A 4JWGA 4KDZA 3QUVA 4YQOA 4YQPA 2HA8A 2V3JA 5FAIA 4YQ3A 3IC6A 3GYQA 5CO4A 2CX8A 2EGWA 3BBEA 4J3CA 1NS5A 3KTYA 4KGNA 4CNDA 4YQ9A 4YQ0A 1GZ0A 1UAJA 3N4JA 1Z85A 4JAKA 1VHYA 4RG1A 4E8BA 1VHKA 1OY5A 4X3LA 1NXZA 4YVKA 4MCBA 3BBDA 4YQQA 1O6DA 3AI9X 4FAKA 3AIAA 4YQ7A 1V6ZA 4JWFA 4YQGA 2Z0YA 3IEFA 4YQLA 4L69A 4YQRA 3O7BA 4YQCA 2V3KA 1MXIA 1X7OA 4YQSA 4YVIA 1V2XA 4YQKA 1TO0A 4YPXA 5GMBA 4IG6A 4YQBA 1J85A 4YQ8A 4YQDA 4YQ2A 3L8UA 4YVHA 4YPZA 4CNGA 1P9PA 2O3AA 3NK6A 3NK7A 4YQJA 5D9FA 3DCMX 3OIIA 1VH0A 4FMWA 4YQ1A 1K3RA 2I6DA 3KNUA 4CNFA 3BBHA 3OIJA 1UAMA 3ONPA 4YPWA 3KW2A 4YQNA 4MCCA 1UALA 5GMCA 2QMMA 1X7PA 4YPYA 4XBOA 4JWJA 1UAKA 4JALA 5GM8A 4MCDA 4CNEA 1IPAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YQ6 A;  4YQ4 A;  4H3Z A;  4YQI A;  4H3Y A;  3ILK A;  3AXZ A;  2EGV A;  2YY8 A;  4X3M A;  4YQ5 A;  4YQA A;  4YVJ A;  3E5Y A;  3OIN A;  4PZK A;  3N4K A;  1ZJR A;  4YVG A;  4YQT A;  2QWV A;  3KY7 A;  4KDZ A;  3QUV A;  4YQO A;  4YQP A;  2HA8 A;  2V3J A;  5FAI A;  4YQ3 A;  3IC6 A;  3GYQ A;  5CO4 A;  2CX8 A;  2EGW A;  3BBE A;  4J3C A;  1NS5 A;  3KTY A;  4KGN A;  4CND A;  4YQ9 A;  4YQ0 A;  1GZ0 A;  1UAJ A;  3N4J A;  1Z85 A;  4JAK A;  1VHY A;  4RG1 A;  4E8B A;  1VHK A;  1OY5 A;  4X3L A;  1NXZ A;  4YVK A;  4MCB A;  3BBD A;  4YQQ A;  1O6D A;  3AI9 X;  4FAK A;  3AIA A;  4YQ7 A;  1V6Z A;  4YQG A;  2Z0Y A;  3IEF A;  4YQL A;  4L69 A;  4YQR A;  3O7B A;  4YQC A;  2V3K A;  1MXI A;  1X7O A;  4YQS A;  4YVI A;  1V2X A;  4YQK A;  1TO0 A;  4YPX A;  5GMB A;  4IG6 A;  4YQB A;  1J85 A;  4YQ8 A;  4YQD A;  4YQ2 A;  3L8U A;  4YVH A;  4YPZ A;  4CNG A;  1P9P A;  2O3A A;  3NK6 A;  3NK7 A;  4YQJ A;  5D9F A;  3DCM X;  3OII A;  1VH0 A;  4YQ1 A;  1K3R A;  2I6D A;  3KNU A;  4CNF A;  3BBH A;  3OIJ A;  1UAM A;  3ONP A;  4YPW A;  3KW2 A;  4YQN A;  4MCC A;  1UAL A;  5GMC A;  2QMM A;  1X7P A;  4YPY A;  4XBO A;  1UAK A;  4JAL A;  5GM8 A;  4MCD A;  4CNE A;  1IPA A; 
#chains in the Genus database with same CATH topology
 4YQ6 A;  4YQ4 A;  4H3Z A;  4YQI A;  4H3Y A;  1JHG A;  4JWH A;  3ILK A;  3AXZ A;  2EGV A;  2YY8 A;  4X3M A;  4YQ5 A;  4YQA A;  4YVJ A;  3E5Y A;  3OIN A;  4PZK A;  3N4K A;  1ZJR A;  1MI7 R;  4YVG A;  4YQT A;  2QWV A;  3KY7 A;  4JWG A;  4KDZ A;  3QUV A;  4YQO A;  4YQP A;  2HA8 A;  2V3J A;  5FAI A;  4YQ3 A;  3IC6 A;  3GYQ A;  5CO4 A;  2CX8 A;  2EGW A;  3BBE A;  4J3C A;  1NS5 A;  3KTY A;  4KGN A;  4CND A;  4YQ9 A;  4YQ0 A;  1TRR A;  1GZ0 A;  1UAJ A;  3N4J A;  1Z85 A;  4JAK A;  1VHY A;  4RG1 A;  4E8B A;  1VHK A;  1OY5 A;  4X3L A;  1NXZ A;  4YVK A;  2XDI A;  4MCB A;  3BBD A;  4YQQ A;  1O6D A;  3AI9 X;  4FAK A;  3AIA A;  4YQ7 A;  1WRP R;  1V6Z A;  4JWF A;  4YQG A;  2Z0Y A;  3IEF A;  4YQL A;  4L69 A;  4YQR A;  3O7B A;  4YQC A;  2V3K A;  1TRO A;  1MXI A;  1X7O A;  4YQS A;  4YVI A;  3SSW N;  1V2X A;  1WRT R;  3FRW A;  4YQK A;  1TO0 A;  4YPX A;  5GMB A;  4IG6 A;  4YQB A;  1J85 A;  1ZT9 A;  4YQ8 A;  4YQD A;  4YQ2 A;  3L8U A;  4YVH A;  4YPZ A;  4CNG A;  3G1C A;  1P9P A;  2O3A A;  3NK6 A;  3NK7 A;  4YQJ A;  3SSX N;  5D9F A;  3DCM X;  3OII A;  1VH0 A;  4FMW A;  4YQ1 A;  1K3R A;  2I6D A;  3KNU A;  4CNF A;  3BBH A;  3OIJ A;  1UAM A;  3ONP A;  3KOR A;  4YPW A;  3KW2 A;  4YQN A;  1CO0 A;  4MCC A;  1UAL A;  5GMC A;  1RCS A;  2QMM A;  1X7P A;  4YPY A;  4XBO A;  3WRP A;  1UAK A;  4JAL A;  4JWJ A;  1WRS R;  5GM8 A;  4MCD A;  2OZ9 R;  4CNE A;  1IPA A; 
#chains in the Genus database with same CATH homology
 4YQ6 A;  4YQ4 A;  4H3Z A;  4YQI A;  4H3Y A;  4JWH A;  3ILK A;  3AXZ A;  2EGV A;  2YY8 A;  4X3M A;  4YQ5 A;  4YQA A;  4YVJ A;  3E5Y A;  3OIN A;  4PZK A;  3N4K A;  1ZJR A;  4YVG A;  4YQT A;  2QWV A;  3KY7 A;  4JWG A;  4KDZ A;  3QUV A;  4YQO A;  4YQP A;  2HA8 A;  2V3J A;  5FAI A;  4YQ3 A;  3IC6 A;  3GYQ A;  5CO4 A;  2CX8 A;  2EGW A;  3BBE A;  4J3C A;  1NS5 A;  3KTY A;  4KGN A;  4CND A;  4YQ9 A;  4YQ0 A;  1GZ0 A;  1UAJ A;  3N4J A;  1Z85 A;  4JAK A;  1VHY A;  4RG1 A;  4E8B A;  1VHK A;  1OY5 A;  4X3L A;  1NXZ A;  4YVK A;  4MCB A;  3BBD A;  4YQQ A;  1O6D A;  3AI9 X;  4FAK A;  3AIA A;  4YQ7 A;  1V6Z A;  4JWF A;  4YQG A;  2Z0Y A;  3IEF A;  4YQL A;  4L69 A;  4YQR A;  3O7B A;  4YQC A;  2V3K A;  1MXI A;  1X7O A;  4YQS A;  4YVI A;  1V2X A;  4YQK A;  1TO0 A;  4YPX A;  5GMB A;  4IG6 A;  4YQB A;  1J85 A;  4YQ8 A;  4YQD A;  4YQ2 A;  3L8U A;  4YVH A;  4YPZ A;  4CNG A;  1P9P A;  2O3A A;  3NK6 A;  3NK7 A;  4YQJ A;  5D9F A;  3DCM X;  3OII A;  1VH0 A;  4FMW A;  4YQ1 A;  1K3R A;  2I6D A;  3KNU A;  4CNF A;  3BBH A;  3OIJ A;  1UAM A;  3ONP A;  4YPW A;  3KW2 A;  4YQN A;  4MCC A;  1UAL A;  5GMC A;  2QMM A;  1X7P A;  4YPY A;  4XBO A;  4JWJ A;  1UAK A;  4JAL A;  5GM8 A;  4MCD A;  4CNE A;  1IPA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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