4YVHA

Crystal structure of h. influenzae trmd in complex with sinefungin
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
Knots found
sequence length
248
structure length
240
Chain Sequence
SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.
pubmed doi rcsb
molecule tags Transferase
source organism Haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd)
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 74
structure length 240
sequence length 248
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2015-03-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4yvhA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4yvhA01
3KNUA 1X7PA 4YQIA 4YQ1A 3E5YA 1V6ZA 3IEFA 4YQOA 4YQ3A 4YVIA 1Z85A 2V3KA 2Z0YA 4YVHA 4YQ5A 3AIAA 4YVJA 4H3YA 3L8UA 3QUVA 4YQKA 3N4JA 2HA8A 4YQ6A 4KGNA 3OINA 2QMMA 2CX8A 4J3CA 4YVGA 5GMCA 4CNDA 4RG1A 1X7OA 3OIJA 4H3ZA 3AXZA 4YQPA 3OIIA 1MXIA 3KW2A 1UALA 4L69A 1P9PA 3NK6A 4JALA 4YQSA 5D9FA 4YQLA 2EGWA 5GM8A 1IPAA 2QWVA 3GYQA 4XBOA 1UAJA 2YY8A 1UAKA 4CNFA 1VHKA 2EGVA 4CNGA 4FAKA 1K3RA 3ILKA 1V2XA 4YQ4A 3BBEA 1VH0A 4YQJA 1NXZA 1UAMA 4YQNA 3AI9X 2V3JA 4YQ8A 4YQ0A 3KTYA 2O3AA 4MCBA 3N4KA 3BBDA 4YPXA 1GZ0A 4E8BA 4YQ9A 2I6DA 5GMBA 1OY5A 3IC6A 3BBHA 4YQRA 4PZKA 1ZJRA 3NK7A 4YQQA 4YQAA 3KY7A 4X3LA 3DCMX 4YQCA 4YQGA 4MCCA 4CNEA 1NS5A 4YPZA 4YPYA 1O6DA 4YQDA 4YQBA 4IG6A 5CO4A 3O7BA 3ONPA 4YPWA 4YVKA 4KDZA 4YQ2A 5FAIA 1VHYA 1J85A 4JAKA 4X3MA 4YQ7A 4YQTA 4MCDA 1TO0A
chains in the Genus database with same CATH superfamily
3KNUA 1X7PA 4YQIA 4YQ1A 3E5YA 1V6ZA 3IEFA 4YQOA 4YQ3A 4YVIA 3KORA 1Z85A 2V3KA 2Z0YA 1WRTR 4YVHA 4YQ5A 3AIAA 1MI7R 4YVJA 4H3YA 3L8UA 3QUVA 4YQKA 4JWFA 3N4JA 2HA8A 4YQ6A 4KGNA 3OINA 2QMMA 2CX8A 3FRWA 4J3CA 4YVGA 5GMCA 4CNDA 4RG1A 1X7OA 2XDIA 3OIJA 4H3ZA 3AXZA 4YQPA 3OIIA 1MXIA 3KW2A 1UALA 4L69A 1P9PA 3NK6A 4JALA 4YQSA 5D9FA 1CO0A 4YQLA 2EGWA 5GM8A 1IPAA 2QWVA 3GYQA 4XBOA 1UAJA 2YY8A 1UAKA 4CNFA 1TROA 1VHKA 2EGVA 4CNGA 4FAKA 1K3RA 3ILKA 1V2XA 4YQ4A 3BBEA 1VH0A 4YQJA 1NXZA 1UAMA 1ZT9A 4YQNA 1WRSR 4JWHA 3AI9X 2V3JA 4YQ8A 4YQ0A 3KTYA 2O3AA 4MCBA 3N4KA 4FMWA 3BBDA 4YPXA 1GZ0A 4E8BA 4YQ9A 2I6DA 5GMBA 1OY5A 3IC6A 3BBHA 4YQRA 4PZKA 1ZJRA 3NK7A 1WRPR 4YQQA 4YQAA 3SSWN 3KY7A 4X3LA 3DCMX 4YQCA 4YQGA 4MCCA 4CNEA 1TRRA 1NS5A 4YPZA 4YPYA 1O6DA 2OZ9R 4YQDA 4YQBA 4IG6A 5CO4A 3O7BA 3ONPA 3G1CA 4YPWA 4YVKA 4KDZA 4YQ2A 5FAIA 1RCSA 3WRPA 1VHYA 1J85A 4JAKA 1JHGA 4JWGA 3SSXN 4X3MA 4YQ7A 4YQTA 4JWJA 4MCDA 1TO0A
chains in the Genus database with same CATH topology
3KNUA 1X7PA 4YQIA 4YQ1A 3E5YA 1V6ZA 3IEFA 4YQOA 4YQ3A 4YVIA 1Z85A 2V3KA 2Z0YA 4YVHA 4YQ5A 3AIAA 4YVJA 4H3YA 3L8UA 3QUVA 4YQKA 4JWFA 3N4JA 2HA8A 4YQ6A 4KGNA 3OINA 2QMMA 2CX8A 4J3CA 4YVGA 5GMCA 4CNDA 4RG1A 1X7OA 3OIJA 4H3ZA 3AXZA 4YQPA 3OIIA 1MXIA 3KW2A 1UALA 4L69A 1P9PA 3NK6A 4JALA 4YQSA 5D9FA 4YQLA 2EGWA 5GM8A 1IPAA 2QWVA 3GYQA 4XBOA 1UAJA 2YY8A 1UAKA 4CNFA 1VHKA 2EGVA 4CNGA 4FAKA 1K3RA 3ILKA 1V2XA 4YQ4A 3BBEA 1VH0A 4YQJA 1NXZA 1UAMA 4YQNA 4JWHA 3AI9X 2V3JA 4YQ8A 4YQ0A 3KTYA 2O3AA 4MCBA 3N4KA 4FMWA 3BBDA 4YPXA 1GZ0A 4E8BA 4YQ9A 2I6DA 5GMBA 1OY5A 3IC6A 3BBHA 4YQRA 4PZKA 1ZJRA 3NK7A 4YQQA 4YQAA 3KY7A 4X3LA 3DCMX 4YQCA 4YQGA 4MCCA 4CNEA 1NS5A 4YPZA 4YPYA 1O6DA 4YQDA 4YQBA 4IG6A 5CO4A 3O7BA 3ONPA 4YPWA 4YVKA 4KDZA 4YQ2A 5FAIA 1VHYA 1J85A 4JAKA 4JWGA 4X3MA 4YQ7A 4YQTA 4JWJA 4MCDA 1TO0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KNU A;  1X7P A;  4YQI A;  4YQ1 A;  3E5Y A;  1V6Z A;  3IEF A;  4YQO A;  4YQ3 A;  4YVI A;  1Z85 A;  2V3K A;  2Z0Y A;  4YVH A;  4YQ5 A;  3AIA A;  4YVJ A;  4H3Y A;  3L8U A;  3QUV A;  4YQK A;  3N4J A;  2HA8 A;  4YQ6 A;  4KGN A;  3OIN A;  2QMM A;  2CX8 A;  4J3C A;  4YVG A;  5GMC A;  4CND A;  4RG1 A;  1X7O A;  3OIJ A;  4H3Z A;  3AXZ A;  4YQP A;  3OII A;  1MXI A;  3KW2 A;  1UAL A;  4L69 A;  1P9P A;  3NK6 A;  4JAL A;  4YQS A;  5D9F A;  4YQL A;  2EGW A;  5GM8 A;  1IPA A;  2QWV A;  3GYQ A;  4XBO A;  1UAJ A;  2YY8 A;  1UAK A;  4CNF A;  1VHK A;  2EGV A;  4CNG A;  4FAK A;  1K3R A;  3ILK A;  1V2X A;  4YQ4 A;  3BBE A;  1VH0 A;  4YQJ A;  1NXZ A;  1UAM A;  4YQN A;  3AI9 X;  2V3J A;  4YQ8 A;  4YQ0 A;  3KTY A;  2O3A A;  4MCB A;  3N4K A;  3BBD A;  4YPX A;  1GZ0 A;  4E8B A;  4YQ9 A;  2I6D A;  5GMB A;  1OY5 A;  3IC6 A;  3BBH A;  4YQR A;  4PZK A;  1ZJR A;  3NK7 A;  4YQQ A;  4YQA A;  3KY7 A;  4X3L A;  3DCM X;  4YQC A;  4YQG A;  4MCC A;  4CNE A;  1NS5 A;  4YPZ A;  4YPY A;  1O6D A;  4YQD A;  4YQB A;  4IG6 A;  5CO4 A;  3O7B A;  3ONP A;  4YPW A;  4YVK A;  4KDZ A;  4YQ2 A;  5FAI A;  1VHY A;  1J85 A;  4JAK A;  4X3M A;  4YQ7 A;  4YQT A;  4MCD A;  1TO0 A; 
#chains in the Genus database with same CATH topology
 3KNU A;  1X7P A;  4YQI A;  4YQ1 A;  3E5Y A;  1V6Z A;  3IEF A;  4YQO A;  4YQ3 A;  4YVI A;  3KOR A;  1Z85 A;  2V3K A;  2Z0Y A;  1WRT R;  4YVH A;  4YQ5 A;  3AIA A;  1MI7 R;  4YVJ A;  4H3Y A;  3L8U A;  3QUV A;  4YQK A;  4JWF A;  3N4J A;  2HA8 A;  4YQ6 A;  4KGN A;  3OIN A;  2QMM A;  2CX8 A;  3FRW A;  4J3C A;  4YVG A;  5GMC A;  4CND A;  4RG1 A;  1X7O A;  2XDI A;  3OIJ A;  4H3Z A;  3AXZ A;  4YQP A;  3OII A;  1MXI A;  3KW2 A;  1UAL A;  4L69 A;  1P9P A;  3NK6 A;  4JAL A;  4YQS A;  5D9F A;  1CO0 A;  4YQL A;  2EGW A;  5GM8 A;  1IPA A;  2QWV A;  3GYQ A;  4XBO A;  1UAJ A;  2YY8 A;  1UAK A;  4CNF A;  1TRO A;  1VHK A;  2EGV A;  4CNG A;  4FAK A;  1K3R A;  3ILK A;  1V2X A;  4YQ4 A;  3BBE A;  1VH0 A;  4YQJ A;  1NXZ A;  1UAM A;  1ZT9 A;  4YQN A;  1WRS R;  4JWH A;  3AI9 X;  2V3J A;  4YQ8 A;  4YQ0 A;  3KTY A;  2O3A A;  4MCB A;  3N4K A;  4FMW A;  3BBD A;  4YPX A;  1GZ0 A;  4E8B A;  4YQ9 A;  2I6D A;  5GMB A;  1OY5 A;  3IC6 A;  3BBH A;  4YQR A;  4PZK A;  1ZJR A;  3NK7 A;  1WRP R;  4YQQ A;  4YQA A;  3SSW N;  3KY7 A;  4X3L A;  3DCM X;  4YQC A;  4YQG A;  4MCC A;  4CNE A;  1TRR A;  1NS5 A;  4YPZ A;  4YPY A;  1O6D A;  2OZ9 R;  4YQD A;  4YQB A;  4IG6 A;  5CO4 A;  3O7B A;  3ONP A;  3G1C A;  4YPW A;  4YVK A;  4KDZ A;  4YQ2 A;  5FAI A;  1RCS A;  3WRP A;  1VHY A;  1J85 A;  4JAK A;  1JHG A;  4JWG A;  3SSX N;  4X3M A;  4YQ7 A;  4YQT A;  4JWJ A;  4MCD A;  1TO0 A; 
#chains in the Genus database with same CATH homology
 3KNU A;  1X7P A;  4YQI A;  4YQ1 A;  3E5Y A;  1V6Z A;  3IEF A;  4YQO A;  4YQ3 A;  4YVI A;  1Z85 A;  2V3K A;  2Z0Y A;  4YVH A;  4YQ5 A;  3AIA A;  4YVJ A;  4H3Y A;  3L8U A;  3QUV A;  4YQK A;  4JWF A;  3N4J A;  2HA8 A;  4YQ6 A;  4KGN A;  3OIN A;  2QMM A;  2CX8 A;  4J3C A;  4YVG A;  5GMC A;  4CND A;  4RG1 A;  1X7O A;  3OIJ A;  4H3Z A;  3AXZ A;  4YQP A;  3OII A;  1MXI A;  3KW2 A;  1UAL A;  4L69 A;  1P9P A;  3NK6 A;  4JAL A;  4YQS A;  5D9F A;  4YQL A;  2EGW A;  5GM8 A;  1IPA A;  2QWV A;  3GYQ A;  4XBO A;  1UAJ A;  2YY8 A;  1UAK A;  4CNF A;  1VHK A;  2EGV A;  4CNG A;  4FAK A;  1K3R A;  3ILK A;  1V2X A;  4YQ4 A;  3BBE A;  1VH0 A;  4YQJ A;  1NXZ A;  1UAM A;  4YQN A;  4JWH A;  3AI9 X;  2V3J A;  4YQ8 A;  4YQ0 A;  3KTY A;  2O3A A;  4MCB A;  3N4K A;  4FMW A;  3BBD A;  4YPX A;  1GZ0 A;  4E8B A;  4YQ9 A;  2I6D A;  5GMB A;  1OY5 A;  3IC6 A;  3BBH A;  4YQR A;  4PZK A;  1ZJR A;  3NK7 A;  4YQQ A;  4YQA A;  3KY7 A;  4X3L A;  3DCM X;  4YQC A;  4YQG A;  4MCC A;  4CNE A;  1NS5 A;  4YPZ A;  4YPY A;  1O6D A;  4YQD A;  4YQB A;  4IG6 A;  5CO4 A;  3O7B A;  3ONP A;  4YPW A;  4YVK A;  4KDZ A;  4YQ2 A;  5FAI A;  1VHY A;  1J85 A;  4JAK A;  4JWG A;  4X3M A;  4YQ7 A;  4YQT A;  4JWJ A;  4MCD A;  1TO0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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