4YVKA

Crystal structure of h. influenzae trmd in complex with sinefungin and trna variant (g36c)
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
Knots found
sequence length
248
structure length
239
Chain Sequence
SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.
pubmed doi rcsb
molecule tags Transferase/rna
source organism Haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd)
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 68
structure length 239
sequence length 248
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2015-03-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4yvkA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4yvkA01
1GZ0A 4YQAA 2EGVA 2HA8A 1P9PA 3AIAA 4MCBA 4YPZA 4CNEA 3E5YA 4J3CA 4JALA 5GMBA 4MCDA 1VHKA 4X3MA 4YPWA 4YQJA 1VHYA 4JAKA 3N4KA 3BBHA 1IPAA 4KGNA 3L8UA 3O7BA 2Z0YA 3DCMX 3KW2A 4YQ2A 4YVKA 4YPXA 5CO4A 4YQGA 4YQ0A 4CNFA 4IG6A 1ZJRA 3AXZA 4YQ6A 4CNGA 3BBEA 4YVGA 4MCCA 2V3JA 1MXIA 2YY8A 1Z85A 4X3LA 4H3ZA 2QWVA 4RG1A 5FAIA 3BBDA 5GM8A 1VH0A 2CX8A 4YVIA 4YQ3A 4YQTA 3ONPA 3IC6A 4L69A 4YQKA 4CNDA 4YQCA 1V2XA 3ILKA 4E8BA 1X7PA 4YQBA 4YQNA 1NS5A 4PZKA 4YQ1A 4YQ5A 3KTYA 2V3KA 4YQ9A 1UAMA 4YQ8A 1UAKA 1X7OA 3NK6A 4YVJA 4YQSA 4FAKA 3NK7A 2I6DA 4YQOA 5GMCA 1UAJA 4XBOA 3OINA 1O6DA 3KNUA 4KDZA 3AI9X 3OIJA 3GYQA 5D9FA 4YQ7A 3OIIA 1UALA 2O3AA 4H3YA 4YPYA 4YVHA 4YQRA 1J85A 1OY5A 2QMMA 1NXZA 4YQPA 3IEFA 1TO0A 1V6ZA 4YQDA 4YQIA 1K3RA 3QUVA 4YQ4A 3KY7A 3N4JA 2EGWA 4YQLA 4YQQA
chains in the Genus database with same CATH superfamily
1GZ0A 4YQAA 2EGVA 2HA8A 1P9PA 3AIAA 4MCBA 4YPZA 4CNEA 3E5YA 4J3CA 4JALA 5GMBA 4MCDA 4JWJA 1VHKA 4X3MA 4YPWA 4YQJA 1VHYA 4JAKA 3N4KA 3BBHA 1IPAA 4KGNA 1TROA 1TRRA 1CO0A 3L8UA 3O7BA 1ZT9A 2Z0YA 3DCMX 3KW2A 4YQ2A 4YVKA 4YPXA 5CO4A 4YQGA 3SSWN 1WRSR 4YQ0A 4JWFA 4CNFA 4IG6A 1ZJRA 3AXZA 4YQ6A 4CNGA 3BBEA 3SSXN 4YVGA 3FRWA 4MCCA 2V3JA 1MXIA 2YY8A 1Z85A 4X3LA 4H3ZA 2QWVA 4RG1A 5FAIA 1WRPR 4FMWA 3BBDA 5GM8A 4JWHA 1VH0A 2CX8A 4YVIA 2XDIA 4YQ3A 4YQTA 3ONPA 1RCSA 3IC6A 4L69A 4YQKA 4CNDA 4YQCA 1JHGA 1V2XA 3ILKA 4E8BA 1X7PA 4YQBA 4YQNA 1NS5A 4PZKA 4YQ1A 4YQ5A 3KTYA 2V3KA 4YQ9A 1UAMA 4YQ8A 1UAKA 1X7OA 3NK6A 4YVJA 4YQSA 4FAKA 3WRPA 3NK7A 2I6DA 4YQOA 5GMCA 1MI7R 1UAJA 4XBOA 3OINA 1O6DA 3KNUA 4KDZA 3AI9X 3OIJA 3GYQA 5D9FA 4YQ7A 3OIIA 1UALA 2O3AA 4H3YA 4YPYA 4YVHA 4YQRA 4JWGA 1J85A 1OY5A 2QMMA 2OZ9R 1NXZA 4YQPA 3IEFA 3KORA 1TO0A 1V6ZA 4YQDA 4YQIA 1WRTR 1K3RA 3G1CA 3QUVA 4YQ4A 3KY7A 3N4JA 2EGWA 4YQLA 4YQQA
chains in the Genus database with same CATH topology
1GZ0A 4YQAA 2EGVA 2HA8A 1P9PA 3AIAA 4MCBA 4YPZA 4CNEA 3E5YA 4J3CA 4JALA 5GMBA 4MCDA 4JWJA 1VHKA 4X3MA 4YPWA 4YQJA 1VHYA 4JAKA 3N4KA 3BBHA 1IPAA 4KGNA 3L8UA 3O7BA 2Z0YA 3DCMX 3KW2A 4YQ2A 4YVKA 4YPXA 5CO4A 4YQGA 4YQ0A 4JWFA 4CNFA 4IG6A 1ZJRA 3AXZA 4YQ6A 4CNGA 3BBEA 4YVGA 4MCCA 2V3JA 1MXIA 2YY8A 1Z85A 4X3LA 4H3ZA 2QWVA 4RG1A 5FAIA 4FMWA 3BBDA 5GM8A 4JWHA 1VH0A 2CX8A 4YVIA 4YQ3A 4YQTA 3ONPA 3IC6A 4L69A 4YQKA 4CNDA 4YQCA 1V2XA 3ILKA 4E8BA 1X7PA 4YQBA 4YQNA 1NS5A 4PZKA 4YQ1A 4YQ5A 3KTYA 2V3KA 4YQ9A 1UAMA 4YQ8A 1UAKA 1X7OA 3NK6A 4YVJA 4YQSA 4FAKA 3NK7A 2I6DA 4YQOA 5GMCA 1UAJA 4XBOA 3OINA 1O6DA 3KNUA 4KDZA 3AI9X 3OIJA 3GYQA 5D9FA 4YQ7A 3OIIA 1UALA 2O3AA 4H3YA 4YPYA 4YVHA 4YQRA 4JWGA 1J85A 1OY5A 2QMMA 1NXZA 4YQPA 3IEFA 1TO0A 1V6ZA 4YQDA 4YQIA 1K3RA 3QUVA 4YQ4A 3KY7A 3N4JA 2EGWA 4YQLA 4YQQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GZ0 A;  4YQA A;  2EGV A;  2HA8 A;  1P9P A;  3AIA A;  4MCB A;  4YPZ A;  4CNE A;  3E5Y A;  4J3C A;  4JAL A;  5GMB A;  4MCD A;  1VHK A;  4X3M A;  4YPW A;  4YQJ A;  1VHY A;  4JAK A;  3N4K A;  3BBH A;  1IPA A;  4KGN A;  3L8U A;  3O7B A;  2Z0Y A;  3DCM X;  3KW2 A;  4YQ2 A;  4YVK A;  4YPX A;  5CO4 A;  4YQG A;  4YQ0 A;  4CNF A;  4IG6 A;  1ZJR A;  3AXZ A;  4YQ6 A;  4CNG A;  3BBE A;  4YVG A;  4MCC A;  2V3J A;  1MXI A;  2YY8 A;  1Z85 A;  4X3L A;  4H3Z A;  2QWV A;  4RG1 A;  5FAI A;  3BBD A;  5GM8 A;  1VH0 A;  2CX8 A;  4YVI A;  4YQ3 A;  4YQT A;  3ONP A;  3IC6 A;  4L69 A;  4YQK A;  4CND A;  4YQC A;  1V2X A;  3ILK A;  4E8B A;  1X7P A;  4YQB A;  4YQN A;  1NS5 A;  4PZK A;  4YQ1 A;  4YQ5 A;  3KTY A;  2V3K A;  4YQ9 A;  1UAM A;  4YQ8 A;  1UAK A;  1X7O A;  3NK6 A;  4YVJ A;  4YQS A;  4FAK A;  3NK7 A;  2I6D A;  4YQO A;  5GMC A;  1UAJ A;  4XBO A;  3OIN A;  1O6D A;  3KNU A;  4KDZ A;  3AI9 X;  3OIJ A;  3GYQ A;  5D9F A;  4YQ7 A;  3OII A;  1UAL A;  2O3A A;  4H3Y A;  4YPY A;  4YVH A;  4YQR A;  1J85 A;  1OY5 A;  2QMM A;  1NXZ A;  4YQP A;  3IEF A;  1TO0 A;  1V6Z A;  4YQD A;  4YQI A;  1K3R A;  3QUV A;  4YQ4 A;  3KY7 A;  3N4J A;  2EGW A;  4YQL A;  4YQQ A; 
#chains in the Genus database with same CATH topology
 1GZ0 A;  4YQA A;  2EGV A;  2HA8 A;  1P9P A;  3AIA A;  4MCB A;  4YPZ A;  4CNE A;  3E5Y A;  4J3C A;  4JAL A;  5GMB A;  4MCD A;  4JWJ A;  1VHK A;  4X3M A;  4YPW A;  4YQJ A;  1VHY A;  4JAK A;  3N4K A;  3BBH A;  1IPA A;  4KGN A;  1TRO A;  1TRR A;  1CO0 A;  3L8U A;  3O7B A;  1ZT9 A;  2Z0Y A;  3DCM X;  3KW2 A;  4YQ2 A;  4YVK A;  4YPX A;  5CO4 A;  4YQG A;  3SSW N;  1WRS R;  4YQ0 A;  4JWF A;  4CNF A;  4IG6 A;  1ZJR A;  3AXZ A;  4YQ6 A;  4CNG A;  3BBE A;  3SSX N;  4YVG A;  3FRW A;  4MCC A;  2V3J A;  1MXI A;  2YY8 A;  1Z85 A;  4X3L A;  4H3Z A;  2QWV A;  4RG1 A;  5FAI A;  1WRP R;  4FMW A;  3BBD A;  5GM8 A;  4JWH A;  1VH0 A;  2CX8 A;  4YVI A;  2XDI A;  4YQ3 A;  4YQT A;  3ONP A;  1RCS A;  3IC6 A;  4L69 A;  4YQK A;  4CND A;  4YQC A;  1JHG A;  1V2X A;  3ILK A;  4E8B A;  1X7P A;  4YQB A;  4YQN A;  1NS5 A;  4PZK A;  4YQ1 A;  4YQ5 A;  3KTY A;  2V3K A;  4YQ9 A;  1UAM A;  4YQ8 A;  1UAK A;  1X7O A;  3NK6 A;  4YVJ A;  4YQS A;  4FAK A;  3WRP A;  3NK7 A;  2I6D A;  4YQO A;  5GMC A;  1MI7 R;  1UAJ A;  4XBO A;  3OIN A;  1O6D A;  3KNU A;  4KDZ A;  3AI9 X;  3OIJ A;  3GYQ A;  5D9F A;  4YQ7 A;  3OII A;  1UAL A;  2O3A A;  4H3Y A;  4YPY A;  4YVH A;  4YQR A;  4JWG A;  1J85 A;  1OY5 A;  2QMM A;  2OZ9 R;  1NXZ A;  4YQP A;  3IEF A;  3KOR A;  1TO0 A;  1V6Z A;  4YQD A;  4YQI A;  1WRT R;  1K3R A;  3G1C A;  3QUV A;  4YQ4 A;  3KY7 A;  3N4J A;  2EGW A;  4YQL A;  4YQQ A; 
#chains in the Genus database with same CATH homology
 1GZ0 A;  4YQA A;  2EGV A;  2HA8 A;  1P9P A;  3AIA A;  4MCB A;  4YPZ A;  4CNE A;  3E5Y A;  4J3C A;  4JAL A;  5GMB A;  4MCD A;  4JWJ A;  1VHK A;  4X3M A;  4YPW A;  4YQJ A;  1VHY A;  4JAK A;  3N4K A;  3BBH A;  1IPA A;  4KGN A;  3L8U A;  3O7B A;  2Z0Y A;  3DCM X;  3KW2 A;  4YQ2 A;  4YVK A;  4YPX A;  5CO4 A;  4YQG A;  4YQ0 A;  4JWF A;  4CNF A;  4IG6 A;  1ZJR A;  3AXZ A;  4YQ6 A;  4CNG A;  3BBE A;  4YVG A;  4MCC A;  2V3J A;  1MXI A;  2YY8 A;  1Z85 A;  4X3L A;  4H3Z A;  2QWV A;  4RG1 A;  5FAI A;  4FMW A;  3BBD A;  5GM8 A;  4JWH A;  1VH0 A;  2CX8 A;  4YVI A;  4YQ3 A;  4YQT A;  3ONP A;  3IC6 A;  4L69 A;  4YQK A;  4CND A;  4YQC A;  1V2X A;  3ILK A;  4E8B A;  1X7P A;  4YQB A;  4YQN A;  1NS5 A;  4PZK A;  4YQ1 A;  4YQ5 A;  3KTY A;  2V3K A;  4YQ9 A;  1UAM A;  4YQ8 A;  1UAK A;  1X7O A;  3NK6 A;  4YVJ A;  4YQS A;  4FAK A;  3NK7 A;  2I6D A;  4YQO A;  5GMC A;  1UAJ A;  4XBO A;  3OIN A;  1O6D A;  3KNU A;  4KDZ A;  3AI9 X;  3OIJ A;  3GYQ A;  5D9F A;  4YQ7 A;  3OII A;  1UAL A;  2O3A A;  4H3Y A;  4YPY A;  4YVH A;  4YQR A;  4JWG A;  1J85 A;  1OY5 A;  2QMM A;  1NXZ A;  4YQP A;  3IEF A;  1TO0 A;  1V6Z A;  4YQD A;  4YQI A;  1K3R A;  3QUV A;  4YQ4 A;  3KY7 A;  3N4J A;  2EGW A;  4YQL A;  4YQQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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