|
100
|
403
|
4i0fA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
15
|
99
|
4j55A |
Crystal structure of multidrug resistant hiv-1 protease clinical isolate pr20 with the potent antiviral inhibitor grl-02031 |
|
95
|
389
|
4ivsA |
Crystal structure of bace1 with its inhibitor |
|
101
|
403
|
4i0jA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors |
|
97
|
388
|
4i0hA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors. |
|
100
|
390
|
4j1cA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((s)-2-amino-5,5-difluoro-4-fluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
101
|
390
|
4j17A |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((s)-2-amino-4-difluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
101
|
400
|
4i10A |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
96
|
390
|
4j1hA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6r)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
102
|
390
|
4j0vA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
94
|
399
|
4i1cA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
19
|
99
|
4jecA |
Joint neutron and x-ray structure of per-deuterated hiv-1 protease in complex with clinical inhibitor amprenavir |
|
16
|
99
|
4j5jA |
Crystal structure of multidrug resistant hiv-1 protease clinical isolate pr20 in complex with amprenavir |
|
104
|
403
|
4i11A |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates. |
|
99
|
403
|
4i0eA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
107
|
402
|
4jpeA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
95
|
390
|
4j1iA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r,6r)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
100
|
390
|
4j0tA |
Crystal structure of bace-1 in complex with 5-ethoxy-pyridine-2-carboxylic acid [3-((r)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
103
|
388
|
4i0iA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors |
|
105
|
402
|
4jpcA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
98
|
390
|
4j1fA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6s)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
103
|
390
|
4j1eA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6s)-2-amino-4-fluoromethyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
98
|
403
|
4i0gA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
15
|
99
|
4hvpA |
Structure of complex of synthetic hiv-1 protease with a substrate-based inhibitor at 2.3 angstroms resolution |
|
104
|
390
|
4h3jA |
Structure of bace bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6-phenyloctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl)benzonitrile |
|
19
|
99
|
4hlaA |
Crystal structure of wild type hiv-1 protease in complex with darunavir |
|
103
|
390
|
4h3fA |
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile |
|
20
|
99
|
4he9A |
Crystal structure of hiv-1 protease mutants i54m complexed with inhibitor grl-0519 |
|
20
|
99
|
4hegA |
Crystal structure of hiv-1 protease mutants r8q complexed with inhibitor grl-0519 |
|
104
|
390
|
4h3iA |
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(3-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile |
|
19
|
99
|
4hdfA |
Crystal structure of hiv-1 protease mutants v82a complexed with inhibitor grl-0519 |
|
19
|
99
|
4hdpA |
Crystal structure of hiv-1 protease mutants i50v complexed with inhibitor grl-0519 |
|
18
|
99
|
4hdbA |
Crystal structure of hiv-1 protease mutants d30n complexed with inhibitor grl-0519 |
|
106
|
390
|
4h3gA |
Structure of bace bound to 2-((7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-2-imino-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-6(2h)-yl)nicotinonitrile |
|
103
|
390
|
4ha5A |
Structure of bace bound to (s)-3-(5-(2-imino-1,4-dimethyl-6-oxohexahydropyrimidin-4-yl)thiophen-3-yl)benzonitrile |
|
17
|
99
|
4gzfA |
Multi-drug resistant hiv-1 protease 769 variant with reduced lrf peptide |
|
15
|
99
|
4gyeA |
Mdr 769 hiv-1 protease in complex with reduced p1f |
|
103
|
389
|
4h1eA |
Structure of bace-1 bound to (7ar)-6-benzoyl-7a-(4-(3-cyanophenyl)thiophen-2-yl)-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-2(3h)-iminium |
|
82
|
340
|
4gj5A |
Crystal structure of renin in complex with nvp-amq838 (compound 5) |
|
85
|
339
|
4gj6A |
Crystal structure of renin in complex with nvp-ayz832 (compound 6a) |
|
16
|
99
|
4gb2A |
Hiv-1 protease (mutant q7k l33i l63i) in complex with a bicyclic pyrrolidine inhibitor |
|
88
|
340
|
4gj8A |
Crystal structure of renin in complex with pkf909-724 (compound 3) |
|
82
|
340
|
4gjbA |
Crystal structure of renin in complex with nvp-bbv031 (compound 6) |
|
103
|
389
|
4gmiA |
Bace-1 in complex with hea-type macrocyclic inhibitor, mv078571 |
|
88
|
339
|
4gj7A |
Crystal structure of renin in complex with nvp-bca079 (compound 12a) |
|
103
|
387
|
4gidA |
Structure of beta-secretase complexed with inhibitor |
|
83
|
338
|
4gj9A |
Crystal structure of renin in complex with gp055321 (compound 4) |
|
89
|
340
|
4gjaA |
Crystal structure of renin in complex with nvp-ayl747 (compound 5) |
|
88
|
340
|
4gjcA |
Crystal structure of renin in complex with nvp-bch965 (compound 9) |
|
87
|
339
|
4gjdA |
Crystal structure of renin in complex with nvp-bgq311 (compound 12) |
