|
101
|
375
|
4b1cA |
New aminoimidazoles as bace-1 inhibitors: from rational design to ab- lowering in brain |
|
99
|
384
|
4b0qA |
Lead generation of bace1 inhibitors by coupling non-amidine new warheads to a known binding scaffold |
|
95
|
390
|
4bekA |
Crystal structure of bace-1 in complex with chemical ligand |
|
103
|
388
|
4b72A |
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab- lowering in brain |
|
102
|
388
|
4acuA |
Aminoimidazoles as bace-1 inhibitors. x-ray crystal structure of beta secretase complexed with compound 14 |
|
98
|
390
|
3zovA |
Crystal structure of bace-1 in complex with chemical ligand |
|
98
|
386
|
4acxA |
Aminoimidazoles as bace-1 inhibitors. x-ray crystal structure of beta secretase complexed with compound 23 |
|
91
|
387
|
3wb4A |
Crystal structure of beta secetase in complex with 2-amino-3,6-dimethyl-6-(2-phenylethyl)-3,4,5,6-tetrahydropyrimidin-4-one |
|
101
|
391
|
3zmgA |
Crystal structure of bace-1 in complex with chemical ligand |
|
92
|
387
|
3wb5A |
Crystal structure of beta secetase in complex with (6s)-2-amino-3,6-dimethyl-6-[(1r,2r)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin-4-one |
|
89
|
387
|
3vv8A |
Crystal structure of beta secetase in complex with 2-amino-3-methyl-6-((1s,2r)-2-(3'-methylbiphenyl-4-yl)cyclopropyl)pyrimidin-4(3h)-one |
|
91
|
389
|
3vv7A |
Crystal structure of beta secetase in complex with 2-amino-6-((1s,2r)-2-(3'-methoxybiphenyl-3-yl)cyclopropyl)-3-methylpyrimidin-4(3h)-one |
|
86
|
389
|
3vv6A |
Crystal structure of beta secetase in complex with 2-amino-3-methyl-6-((1s, 2r)-2-phenylcyclopropyl)pyrimidin-4(3h)-one |
|
99
|
388
|
3vg1A |
Crystal structure of human beta secretase in complex with nvp-bur436, derived from a soaking experiment |
|
101
|
388
|
3vf3A |
Crystal structure of human beta secretase in complex with nvp-bqq711 |
|
102
|
389
|
3veuA |
Crystal structure of human beta secretase in complex with nvp-avi326 |
|
96
|
389
|
3uflA |
Discovery of pyrrolidine-based b-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency |
|
100
|
400
|
3udkA |
Crystal structure of bace with compound 6 |
|
100
|
400
|
3udmA |
Crystal structure of bace with compound 8 |
|
102
|
400
|
3udhA |
Crystal structure of bace with compound 1 |
|
102
|
400
|
3udrA |
Crystal structure of bace with compound 14 |
|
100
|
400
|
3udnA |
Crystal structure of bace with compound 9 |
|
100
|
400
|
3udjA |
Crystal structure of bace with compound 5 |
|
93
|
391
|
3uqwA |
Crystal structure of bace1 with its inhibitor |
|
102
|
400
|
3udyA |
Crystal structure of bace with compound 11 |
|
102
|
400
|
3udpA |
Crystal structure of bace with compound 12 |
|
100
|
400
|
3udqA |
Crystal structure of bace with compound 13 |
|
89
|
392
|
3tplA |
Apo structure of bace1 |
|
96
|
391
|
3tpjA |
Apo structure of bace1 |
|
91
|
387
|
3tprA |
Crystal structure of bace1 complexed with an inhibitor |
|
102
|
390
|
3tppA |
Crystal structure of bace1 complexed with an inhibitor |
|
97
|
387
|
3skfA |
Crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with (2s)-2-((3s)-3-(acetylamino)-3-(butan-2-yl)-2-oxopyrrolidin-1-yl)-n-((2s,3r)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2-yl)-4-phenylbutanamide |
|
86
|
386
|
3skgA |
Crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-n-((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrahydro-3-isoquinolinyl)ethyl)-4-phenylbutanamide |
|
99
|
387
|
3s7mA |
Pyrazolyl and thienyl aminohydantoins as potent bace1 inhibitors |
|
102
|
387
|
3s7lA |
Pyrazolyl and thienyl aminohydantoins as potent bace1 inhibitors |
|
88
|
387
|
3s2oA |
Fragment based discovery and optimisation of bace-1 inhibitors |
|
90
|
387
|
3rviA |
Structure of bace-1 (beta-secretase) in complex with 2-((2-amino-6-o-tolylquinolin-3-yl)methyl)-n-(cyclohexylmethyl)pentanamide |
|
88
|
387
|
3ru1A |
Structure of bace-1 (beta-secretase) in complex with 3-(2-aminoquinolin-3-yl)-n-(cyclohexylmethyl)propanamide |
|
91
|
387
|
3rtmA |
Structure of bace-1 (beta-secretase) in complex with 3-(2-aminoquinolin-3-yl)-n-cyclohexyl-n-methylpropanamide |
|
88
|
387
|
3rsvA |
Structure of bace-1 (beta-secretase) in complex with (r)-3-(2-amino-6-o-tolylquinolin-3-yl)-n-((r)-2,2-dimethyltetrahydro-2h-pyran-4-yl)-2-methylpropanamide |
|
94
|
387
|
3rsxA |
Structure of bace-1 (beta-secretase) in complex with 6-(thiophen-3-yl)quinolin-2-amine |
|
90
|
387
|
3rthA |
Structure of bace-1 (beta-secretase) in complex with 6-(2-(3,3-dimethylbut-1-ynyl)phenyl)quinolin-2-amine |
|
92
|
387
|
3rtnA |
Structure of bace-1 (beta-secretase) in complex with 3-(2-amino-6-o-tolylquinolin-3-yl)-n-cyclohexylpropanamide |
|
100
|
387
|
5v0nA |
Bace1 in complex with inhibitor 5g |
|
91
|
389
|
5tolA |
Crystal structure of beta-site app-cleaving enzyme 1 complexed with n-(3-((4as,7as)-2-amino-4,4a,5,6-tetrahydro-7ah-furo[2,3-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-bromo-2-pyridinecarboxamide |
|
100
|
389
|
5t1uA |
Aminomethyl-derived beta secretase (bace1) inhibitors: engaging gly230 without an anilide functionality |
|
103
|
389
|
5t1wA |
Aminomethyl-derived beta secretase (bace1) inhibitors: engaging gly230 without an anilide functionality |
|
93
|
387
|
5kqfA |
(4~{s},6~{s})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine (compound 12) bound to bace1 |
|
103
|
390
|
5hduA |
Bace-1 incomplex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
106
|
390
|
5he5A |
Bace-1 in complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylamino)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
