|
96
|
389
|
3uqpA |
Crystal structure of bace1 with its inhibitor |
|
96
|
388
|
3u6aA |
Rational design and synthesis of aminopiperazinones as beta secretase (bace) inhibitors |
|
88
|
323
|
1apwE |
Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine-and difluorostatone-containing peptides |
|
85
|
323
|
1aptE |
Crystallographic analysis of a pepstatin analogue binding to the aspartyl proteinase penicillopepsin at 1.8 angstroms resolution |
|
88
|
339
|
5sxnA |
Structure-based design of a new series of n-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors |
|
83
|
339
|
5nfgA |
Structure of recombinant cardosin b from cynara cardunculus |
|
92
|
390
|
5mxdA |
Bace-1 in complex with ligand 32397778 |
|
85
|
339
|
5n70A |
Crystal structure of mature cathepsin d from the tick ixodes ricinus (ircd1) in complex with the n-terminal octapeptide of the propeptid |
|
60
|
375
|
5mktA |
Crystal structure of mouse prorenin |
|
83
|
330
|
5mb3A |
Fragment 333 at a concentration of 50mm in complex with endothiapepsin |
|
83
|
330
|
5mb6A |
Cocktail experiment d: fragments 308 and 333 at 50mm concentration |
|
101
|
393
|
5mcqA |
Crystal structure of bace-1 in complex with active site and exosite binding peptide inhibitor |
|
103
|
393
|
5mcoA |
Crystal structure of bace-1 in complex with active site inhibitor grl-8234 and exosite peptide |
|
83
|
330
|
5mb7A |
Cocktail experiment b: fragments 224 and 236 at 50mm concentration |
|
84
|
330
|
5mb0A |
Cocktail experiment a: fragments 63, 267, and 291 in complex with endothiapepsin |
|
81
|
377
|
5mlgA |
Crystal structure of rat prorenin |
|
101
|
390
|
5mbwA |
Crystal structure of bace-1 in complex with pep#3 |
|
85
|
330
|
5lwrA |
Endothiapepsin in complex with a derivative of fragment 177 |
|
84
|
330
|
5lwsA |
Endothiapepsin in complex with fragment 177 and a derivative thereof |
|
89
|
336
|
5koqA |
Discovery of tak-272: a novel, potent and orally active renin in-hibitor |
|
91
|
337
|
5kotA |
Discovery of tak-272: a novel, potent and orally active renin in-hibitor |
|
86
|
337
|
5kosA |
Discovery of tak-272: a novel, potent and orally active renin in-hibitor |
|
90
|
387
|
5kr8A |
(4~{s},6~{s})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) bound to bace1 |
|
92
|
375
|
5jodA |
Structure of proplasmepsin iv from plasmodium falciparum |
|
90
|
387
|
5ie1A |
Crystal structure of bace1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-n-(3,3-dimethylbutyl)propanamide |
|
74
|
323
|
5i70A |
Crystal structure of plasmepsin iv |
|
100
|
389
|
5i3xA |
Crystal structure of bace1 in complex with aminoquinoline inhibitor 6 |
|
94
|
387
|
5i3yA |
Crystal structure of bace1 in complex with aminoquinoline inhibitor 9 |
|
92
|
388
|
5i3wA |
Crystal structure of bace1 in complex with 2-aminooxazoline-3-azaxanthene inhibitor 2 |
|
104
|
390
|
5hu0A |
Bace1 in complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5-oxo-4-phenylimidazolidin-2-iminium |
|
107
|
391
|
5htzA |
Bace1 in complex with (s)-5-(3-chloro-5-(5-(prop-1-yn-1-yl)pyridin-3-yl)thiophen-2-yl)-2,5-dimethyl-1,2,4-thiadiazinan-3-iminium 1,1-dioxide |
|
102
|
391
|
5hu1A |
Bace1 in complex with (r)-n-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide |
|
102
|
390
|
5ezxA |
Crystal structure of bace-1 in complex with {(1r,2r)-2-[(r)-2-amino-4-(4-difluoromethoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-cyclopropyl}-(5-chloro-pyridin-3-yl)-methanone |
|
105
|
390
|
6fgyA |
Crystal structure of human bace-1 in complex with amino-1,4-oxazine compound 4 |
|
103
|
388
|
6eqmA |
Crystal structure of human bace-1 in complex with cnp520 |
|
95
|
387
|
6ej3A |
Bace1 compound 23 |
|
99
|
409
|
6ej2A |
Bace1 compound 28 |
|
100
|
389
|
6dhcA |
X-ray structure of bace1 in complex with a bicyclic isoxazoline carboxamide as the p3 ligand |
|
111
|
426
|
6c4gA |
Plasmepsin v from plasmodium vivax bound to a transition state mimetic (wehi-601) |
|
95
|
388
|
6c2iA |
Structure of bace-1 (beta-secretase) in complex with : n-(3-((1r,5s,6r)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide |
|
106
|
393
|
6bfdA |
Bace crystal structure with hydroxy pyrrolidine inhibitor |
|
105
|
393
|
6bfwA |
Bace crystal structure with hydroxy morpholine inhibitor |
|
106
|
393
|
6bfeA |
Bace crystal structure with hydroxy pyrrolidine inhibitor |
|
105
|
389
|
6bfxA |
Bace crystal structure with hydroxy pyrrolidine inhibitor |
|
88
|
325
|
6aprE |
Structures of complexes of rhizopuspepsin with pepstatin and other statine-containing inhibitors |
|
92
|
327
|
5yieA |
Crystal structure of kni-10742 bound plasmepsin ii (pmii) from plasmodium falciparum |
|
98
|
389
|
5ygxA |
Structure of bace1 in complex with n-(3-((4r,5r,6s)-2-amino-6-(1,1-difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide |
|
93
|
328
|
5yiaA |
Crystal structure of kni-10343 bound plasmepsin ii (pmii) from plasmodium falciparum |
|
94
|
328
|
5yicA |
Crystal structure of kni-10333 bound plasmepsin ii (pmii) from plasmodium falciparum |
|
98
|
392
|
5ygyA |
Crystal structure of bace1 in complex with (s)-n-(3-(2-amino-6-(fluoromethyl)-4 -methyl-4h-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide |
