The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
50
|
sequence length |
165
|
structure length |
165
|
Chain Sequence |
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| molecule tags |
Isomerase/immunosuppressant
|
| molecule keywords |
PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
|
| publication title |
The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-Cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis with Cyclophilin A.
pubmed doi rcsb |
| source organism |
Homo sapiens
|
| total genus |
50
|
| structure length |
165
|
| sequence length |
165
|
| ec nomenclature |
ec
5.2.1.8: Peptidylprolyl isomerase. |
| pdb deposition date | 1995-09-20 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00160 | Pro_isomerase | Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Beta Barrel | Cyclophilin | Cyclophilin-like |
#chains in the Genus database with same CATH superfamily 1VAI A; 2HE9 A; 1V9T A; 1W8L A; 4N1M A; 2QER A; 2OK3 A; 5DUD A; 1BCK A; 2GW2 A; 1OCA A; 5F66 A; 1A33 A; 2FU0 A; 3T1U A; 2X2D B; 4S1E A; 3O7T A; 5KV4 A; 1CWJ A; 2BIU X; 2BIT X; 5JHE A; 1CWF A; 5KUR A; 2HQ6 A; 3VA7 A; 2IGW A; 5A0E A; 1MZW A; 4N1O A; 1CWI A; 4I9Y A; 4N1P A; 4JJM A; 5KV7 A; 3ICH A; 3ODI A; 2X2C K; 4S1J A; 4YUM A; 5CCN A; 2C3B A; 1A58 A; 3RCF A; 5CCQ A; 4TOT A; 1YND A; 3RCL A; 4YUH A; 2X83 B; 3RCK X; 1CWC A; 2NUL A; 4E1Q A; 3K0N A; 2CMT A; 5KUN A; 1ZKF A; 3MML B; 1CWL A; 5KV0 A; 5KUL A; 3UCH A; 4N1N A; 3BO7 A; 2OSE A; 1AWQ A; 2PLU A; 4J59 A; 4XNC A; 1M9D A; 4JCP A; 5KUO A; 3K0O A; 1M9F A; 5LUD A; 2CYH A; 1AK4 A; 3RFY A; 3RCG A; 1C5F A; 4ZSD A; 2PHC B; 5KUZ A; 2CK1 A; 1E3B A; 1MF8 C; 1M9E A; 1QNG A; 2R99 A; 2RMA A; 2X7K A; 1CWM A; 3JB9 d; 1CWH A; 5CCR A; 4HY7 A; 4O8I A; 1CWB A; 3BT8 A; 1M9X A; 3R57 A; 1DYW A; 2MS4 A; 1CWA A; 2POE A; 2WFI A; 5CBT A; 2ALF A; 1H0P A; 2WFJ A; 5KV5 A; 2Z6W A; 1MIK A; 1M63 C; 3ICI A; 1AWS A; 4DGB A; 4YUG A; 3CYS A; 1IST A; 1XQ7 A; 2MC9 A; 3QYU A; 1RMH A; 3R56 A; 4J5E X; 4N1R A; 3RDA X; 4YUO A; 4YUP A; 1AWV A; 1QOI A; 1IIP A; 2HQJ A; 2A2N A; 1AWU A; 1CYN A; 2B71 A; 3K0Q A; 1VBS A; 1VDN A; 5CBU A; 5KUQ A; 3CYH A; 4J5C X; 4N1Q A; 4DGE A; 4YUI A; 1FGL A; 3RDD A; 1W74 A; 4DGA A; 4J5A X; 2ZP2 A; 1E8K A; 3S6M A; 4CYH A; 3R59 A; 3BKP A; 5CBV A; 2P0O A; 3PMP A; 4FRU A; 2K7N A; 4ZSC A; 3R54 A; 3ORE A; 4IPZ A; 5CCS X; 2X25 B; 5KV6 A; 4N1S A; 1VBT A; 5KV2 A; 4YUK A; 1CWO A; 5CYH A; 4EYV A; 3R4G A; 4YUJ A; 1AWR A; 1XO7 A; 1W8V A; 1CLH A; 3K0P A; 1ZKC A; 3OPF A; 1XWN A; 2WLW A; 3RDC A; 1QNH A; 2CFE A; 4DGC A; 4DGD A; 1NMK A; 1M9C A; 5KUV A; 4R3F A; 3K2C A; 3K0M A; 2ESL A; 3R49 A; 3RDB A; 5KUU A; 4J5B A; 2OJU A; 3RD9 X; 5CBW A; 4YUN A; 1LOP A; 1XYH A; 2RMB A; 5KV3 A; 2RMC A; 5KV1 A; 1ZMF A; 2XGY B; 2HAQ A; 1AWT A; 1IHG A; 2POY A; 1Z81 A; 2N0T A; 4J58 A; 2MZU A; 2X2A A; 3OEP A; 2MVZ A; 4FRV A; 4R3E A; 4O8H A; 1W8M A; 4YUL A; 3K0R A; 1M9Y A; 4J5D X; 1CWK A; 2CPL A; 1J2A A; 3ODL A; 2RS4 A; 5KUW A; 3RCI X; 5KUS A; 1X7F A; 2IGV A; 3MML A; 4LQW A; 3EOV A; #chains in the Genus database with same CATH topology 1VAI A; 2HE9 A; 1V9T A; 1W8L A; 4N1M A; 2QER A; 2OK3 A; 5DUD A; 1BCK A; 2GW2 A; 1OCA A; 5F66 A; 1A33 A; 2FU0 A; 3T1U A; 2X2D B; 4S1E A; 3O7T A; 5KV4 A; 1CWJ A; 2BIU X; 2BIT X; 5JHE A; 1CWF A; 2NNZ A; 2HQ6 A; 5KUR A; 3VA7 A; 2IGW A; 5A0E A; 1MZW A; 4N1O A; 1CWI A; 4I9Y A; 4N1P A; 4JJM A; 5KV7 A; 3ICH A; 3ODI A; 2X2C K; 4S1J A; 4YUM A; 5CCN A; 2C3B A; 1A58 A; 3RCF A; 5CCQ A; 4TOT A; 1ZX8 A; 1YND A; 3RCL A; 4YUH A; 2X83 B; 3RCK X; 1CWC A; 2NUL A; 4E1Q A; 3K0N A; 2CMT A; 5KUN A; 1ZKF A; 3MML B; 1CWL A; 5KV0 A; 5KUL A; 3UCH A; 4N1N A; 3BO7 A; 2OSE A; 1AWQ A; 2PLU A; 4J59 A; 4XNC A; 1M9D A; 4JCP A; 3X27 A; 5KUO A; 3K0O A; 1M9F A; 5LUD A; 2CYH A; 1AK4 A; 3RFY A; 3RCG A; 1C5F A; 4ZSD A; 2PHC B; 5KUZ A; 2CK1 A; 1E3B A; 1MF8 C; 1M9E A; 1QNG A; 2R99 A; 2RMA A; 2X7K A; 1CWM A; 3JB9 d; 1CWH A; 5CCR A; 4HY7 A; 4O8I A; 1CWB A; 3BT8 A; 1M9X A; 3R57 A; 1DYW A; 2MS4 A; 1CWA A; 2POE A; 2WFI A; 5CBT A; 2ALF A; 1H0P A; 2WFJ A; 5KV5 A; 2Z6W A; 1MIK A; 1M63 C; 3ICI A; 1AWS A; 4DGB A; 4YUG A; 3CYS A; 1IST A; 1XQ7 A; 2MC9 A; 3QYU A; 1RMH A; 3R56 A; 4J5E X; 4N1R A; 3RDA X; 4YUO A; 4YUP A; 1AWV A; 1QOI A; 1IIP A; 2HQJ A; 2A2N A; 1AWU A; 1CYN A; 2B71 A; 3K0Q A; 1VBS A; 1VDN A; 5CBU A; 5KUQ A; 3CYH A; 4J5C X; 4N1Q A; 4DGE A; 4YUI A; 1FGL A; 3RDD A; 1W74 A; 4DGA A; 4J5A X; 2ZP2 A; 1E8K A; 3S6M A; 4CYH A; 3R59 A; 3BKP A; 5CBV A; 2P0O A; 3PMP A; 4FRU A; 2K7N A; 4ZSC A; 3R54 A; 3ORE A; 4IPZ A; 5CCS X; 2KA0 A; 2X25 B; 5KV6 A; 4N1S A; 1VBT A; 5KV2 A; 4YUK A; 1CWO A; 5CYH A; 4EYV A; 3R4G A; 4YUJ A; 1AWR A; 1XO7 A; 1W8V A; 1CLH A; 3K0P A; 1ZKC A; 3OPF A; 1XWN A; 2WLW A; 3RDC A; 1QNH A; 2CFE A; 4DGC A; 4DGD A; 1NMK A; 1M9C A; 5KUV A; 4R3F A; 3K2C A; 3K0M A; 2ESL A; 3R49 A; 3RDB A; 5KUU A; 3KOP A; 4J5B A; 2OJU A; 3RD9 X; 5CBW A; 4YUN A; 1LOP A; 1XYH A; 2RMB A; 5KV3 A; 2RMC A; 5KV1 A; 1ZMF A; 2XGY B; 2HAQ A; 1AWT A; 1IHG A; 2POY A; 1Z81 A; 2N0T A; 4J58 A; 2MZU A; 2X2A A; 3OEP A; 2MVZ A; 4FRV A; 4R3E A; 4O8H A; 1W8M A; 4YUL A; 3K0R A; 1M9Y A; 4J5D X; 1CWK A; 2CPL A; 1J2A A; 3ODL A; 2RS4 A; 5KUW A; 3RCI X; 5KUS A; 1X7F A; 2IGV A; 3MML A; 4LQW A; 3EOV A; #chains in the Genus database with same CATH homology 1VAI A; 2HE9 A; 1V9T A; 1W8L A; 4N1M A; 2QER A; 2OK3 A; 5DUD A; 1BCK A; 2GW2 A; 1OCA A; 5F66 A; 1A33 A; 2FU0 A; 3T1U A; 2X2D B; 4S1E A; 3O7T A; 5KV4 A; 1CWJ A; 2BIU X; 2BIT X; 5JHE A; 1CWF A; 5KUR A; 2HQ6 A; 3VA7 A; 2IGW A; 5A0E A; 1MZW A; 4N1O A; 1CWI A; 4I9Y A; 4N1P A; 4JJM A; 5KV7 A; 3ICH A; 3ODI A; 2X2C K; 4S1J A; 4YUM A; 5CCN A; 2C3B A; 1A58 A; 3RCF A; 5CCQ A; 4TOT A; 1YND A; 3RCL A; 4YUH A; 2X83 B; 3RCK X; 1CWC A; 2NUL A; 4E1Q A; 3K0N A; 2CMT A; 5KUN A; 1ZKF A; 3MML B; 1CWL A; 5KV0 A; 5KUL A; 3UCH A; 4N1N A; 3BO7 A; 2OSE A; 1AWQ A; 2PLU A; 4J59 A; 4XNC A; 1M9D A; 4JCP A; 5KUO A; 3K0O A; 1M9F A; 5LUD A; 2CYH A; 1AK4 A; 3RFY A; 3RCG A; 1C5F A; 4ZSD A; 2PHC B; 5KUZ A; 2CK1 A; 1E3B A; 1MF8 C; 1M9E A; 1QNG A; 2R99 A; 2RMA A; 2X7K A; 1CWM A; 3JB9 d; 1CWH A; 5CCR A; 4HY7 A; 4O8I A; 1CWB A; 3BT8 A; 1M9X A; 3R57 A; 1DYW A; 2MS4 A; 1CWA A; 2POE A; 2WFI A; 5CBT A; 2ALF A; 1H0P A; 2WFJ A; 5KV5 A; 2Z6W A; 1MIK A; 1M63 C; 3ICI A; 1AWS A; 4DGB A; 4YUG A; 3CYS A; 1IST A; 1XQ7 A; 2MC9 A; 3QYU A; 1RMH A; 3R56 A; 4J5E X; 4N1R A; 3RDA X; 4YUO A; 4YUP A; 1AWV A; 1QOI A; 1IIP A; 2HQJ A; 2A2N A; 1AWU A; 1CYN A; 2B71 A; 3K0Q A; 1VBS A; 1VDN A; 5CBU A; 5KUQ A; 3CYH A; 4J5C X; 4N1Q A; 4DGE A; 4YUI A; 1FGL A; 3RDD A; 1W74 A; 4DGA A; 4J5A X; 2ZP2 A; 1E8K A; 3S6M A; 4CYH A; 3R59 A; 3BKP A; 5CBV A; 2P0O A; 3PMP A; 4FRU A; 2K7N A; 4ZSC A; 3R54 A; 3ORE A; 4IPZ A; 5CCS X; 2X25 B; 5KV6 A; 4N1S A; 1VBT A; 5KV2 A; 4YUK A; 1CWO A; 5CYH A; 4EYV A; 3R4G A; 4YUJ A; 1AWR A; 1XO7 A; 1W8V A; 1CLH A; 3K0P A; 1ZKC A; 3OPF A; 1XWN A; 2WLW A; 3RDC A; 1QNH A; 2CFE A; 4DGC A; 4DGD A; 1NMK A; 1M9C A; 5KUV A; 4R3F A; 3K2C A; 3K0M A; 2ESL A; 3R49 A; 3RDB A; 5KUU A; 4J5B A; 2OJU A; 3RD9 X; 5CBW A; 4YUN A; 1LOP A; 1XYH A; 2RMB A; 5KV3 A; 2RMC A; 5KV1 A; 1ZMF A; 2XGY B; 2HAQ A; 1AWT A; 1IHG A; 2POY A; 1Z81 A; 2N0T A; 4J58 A; 2MZU A; 2X2A A; 3OEP A; 2MVZ A; 4FRV A; 4R3E A; 4O8H A; 1W8M A; 4YUL A; 3K0R A; 1M9Y A; 4J5D X; 1CWK A; 2CPL A; 1J2A A; 3ODL A; 2RS4 A; 5KUW A; 3RCI X; 5KUS A; 1X7F A; 2IGV A; 3MML A; 4LQW A; 3EOV A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
