1YHQD

Crystal structure of azithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
165
structure length
140
Chain Sequence
FHEMREPRIEKVVVHMGIGHANAEDILGEITGQMPVRTKAKRTVGEFDIREGDPIGAKVTLRDEMAEEFLQTALPLAELATSQFDDTGNFSFGLDVTVNLVRPGYRVAKRDKASRSIPTKHRLNPADAVAFIESTYDVEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 18
structure length 140
sequence length 165
ec nomenclature
pdb deposition date 2005-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00281 Ribosomal_L5 Ribosomal protein L5
D PF00673 Ribosomal_L5_C ribosomal L5P family C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1440.10 Alpha Beta 2-Layer Sandwich 50s Ribosomal Protein L5; Chain: A, 50s Ribosomal Protein L5; Chain: A, 1yhqD00
5DM7D 4IO9D 1YIJD 1YHQD 3CC4D 1VQOD 3CCQD 1VQPD 2OTJD 5GAEF 2QEXD 1VQLD 5JVHD 3CMAD 4UY8F 4WCED 3G4SD 1QVFD 1VQ4D 1IQ4A 3CCED 3CMED 1S72D 5H1SH 2ZJRD 3CCMD 3G6ED 1YJND 1K8AF 1K73F 3CCUD 1Q86F 1VQ9D 1YJWD 3CD6D 2OGKA 3I55D 3CCSD 1VQ6D 3CC7D 3PIOD 4WFAD 4IOCD 1VQ5D 2NRQA 1QVGD 4IOAD 5GAHF 5GAGF 2WNYA 3CCJD 5JVGD 3C9GA 5HL7D 3DLLD 2NWUA 1VQND 5DM6D 1KQSD 1VQMD 1M90F 3G71D 3OW2D 1W2BD 3PIPD 3J7ZF 1YJ9D 3D7AA 3CXCD 1YITD 1KC8F 3CC2D 1VQKD 3I56D 3CCVD 1M1KF 2ZJPD 1N8RF 4U67D 1VQ7D 4WF9D 1JJ2D 3CPWD 3CF5D 1NJIF 1Q7YF 1K9MF 2PZZA 1YI2D 1Q81F 3CCLD 4WFND 2OTLD 2QA4D 1VQ8D 4WFBD 1Q82F 5MLCG 1MJIA 5GADF 2ZJQD 3CCRD 1KD1F
chains in the Genus database with same CATH superfamily
5DM7D 4IO9D 1YIJD 1YHQD 3CC4D 1VQOD 3CCQD 1VQPD 2OTJD 5GAEF 2QEXD 1VQLD 5JVHD 3CMAD 4UY8F 4WCED 3G4SD 1QVFD 1VQ4D 1IQ4A 3CCED 3CMED 1S72D 5H1SH 2ZJRD 3CCMD 3G6ED 1YJND 1K8AF 1K73F 3CCUD 1Q86F 1VQ9D 1YJWD 3CD6D 2OGKA 3I55D 3CCSD 1VQ6D 3CC7D 3PIOD 4WFAD 4IOCD 1VQ5D 2NRQA 1QVGD 4IOAD 5GAHF 5GAGF 2WNYA 3CCJD 5JVGD 3C9GA 5HL7D 3DLLD 2NWUA 1VQND 5DM6D 1KQSD 1VQMD 1M90F 3G71D 3OW2D 1W2BD 3PIPD 3J7ZF 1YJ9D 3D7AA 3CXCD 1YITD 1KC8F 3CC2D 1VQKD 3I56D 3CCVD 1M1KF 2ZJPD 1N8RF 4U67D 1VQ7D 4WF9D 1JJ2D 3CPWD 3CF5D 1NJIF 1Q7YF 1K9MF 2PZZA 1YI2D 1Q81F 3CCLD 4WFND 2OTLD 2QA4D 1VQ8D 4WFBD 1Q82F 5MLCG 1MJIA 5GADF 2ZJQD 3CCRD 1KD1F
chains in the Genus database with same CATH topology
5DM7D 4IO9D 1YIJD 1YHQD 3CC4D 1VQOD 3CCQD 1VQPD 2OTJD 5GAEF 2QEXD 1VQLD 5JVHD 3CMAD 4UY8F 4WCED 3G4SD 1QVFD 1VQ4D 1IQ4A 3CCED 3CMED 1S72D 5H1SH 2ZJRD 3CCMD 3G6ED 1YJND 1K8AF 1K73F 3CCUD 1Q86F 1VQ9D 1YJWD 3CD6D 2OGKA 3I55D 3CCSD 1VQ6D 3CC7D 3PIOD 4WFAD 4IOCD 1VQ5D 2NRQA 1QVGD 4IOAD 5GAHF 5GAGF 2WNYA 3CCJD 5JVGD 3C9GA 5HL7D 3DLLD 2NWUA 1VQND 5DM6D 1KQSD 1VQMD 1M90F 3G71D 3OW2D 1W2BD 3PIPD 3J7ZF 1YJ9D 3D7AA 3CXCD 1YITD 1KC8F 3CC2D 1VQKD 3I56D 3CCVD 1M1KF 2ZJPD 1N8RF 4U67D 1VQ7D 4WF9D 1JJ2D 3CPWD 3CF5D 1NJIF 1Q7YF 1K9MF 2PZZA 1YI2D 1Q81F 3CCLD 4WFND 2OTLD 2QA4D 1VQ8D 4WFBD 1Q82F 5MLCG 1MJIA 5GADF 2ZJQD 3CCRD 1KD1F
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DM7 D;  4IO9 D;  1YIJ D;  1YHQ D;  3CC4 D;  1VQO D;  3CCQ D;  1VQP D;  2OTJ D;  5GAE F;  2QEX D;  1VQL D;  5JVH D;  3CMA D;  4UY8 F;  4WCE D;  3G4S D;  1QVF D;  1VQ4 D;  1IQ4 A;  3CCE D;  3CME D;  1S72 D;  5H1S H;  2ZJR D;  3CCM D;  3G6E D;  1YJN D;  1K8A F;  1K73 F;  3CCU D;  1Q86 F;  1VQ9 D;  1YJW D;  3CD6 D;  2OGK A;  3I55 D;  3CCS D;  1VQ6 D;  3CC7 D;  3PIO D;  4WFA D;  4IOC D;  1VQ5 D;  2NRQ A;  1QVG D;  4IOA D;  5GAH F;  5GAG F;  2WNY A;  3CCJ D;  5JVG D;  3C9G A;  5HL7 D;  3DLL D;  2NWU A;  1VQN D;  5DM6 D;  1KQS D;  1VQM D;  1M90 F;  3G71 D;  3OW2 D;  1W2B D;  3PIP D;  3J7Z F;  1YJ9 D;  3D7A A;  3CXC D;  1YIT D;  1KC8 F;  3CC2 D;  1VQK D;  3I56 D;  3CCV D;  1M1K F;  2ZJP D;  1N8R F;  4U67 D;  1VQ7 D;  4WF9 D;  1JJ2 D;  3CPW D;  3CF5 D;  1NJI F;  1Q7Y F;  1K9M F;  2PZZ A;  1YI2 D;  1Q81 F;  3CCL D;  4WFN D;  2OTL D;  2QA4 D;  1VQ8 D;  4WFB D;  1Q82 F;  5MLC G;  1MJI A;  5GAD F;  2ZJQ D;  3CCR D;  1KD1 F; 
#chains in the Genus database with same CATH topology
 5DM7 D;  4IO9 D;  1YIJ D;  1YHQ D;  3CC4 D;  1VQO D;  3CCQ D;  1VQP D;  2OTJ D;  5GAE F;  2QEX D;  1VQL D;  5JVH D;  3CMA D;  4UY8 F;  4WCE D;  3G4S D;  1QVF D;  1VQ4 D;  1IQ4 A;  3CCE D;  3CME D;  1S72 D;  5H1S H;  2ZJR D;  3CCM D;  3G6E D;  1YJN D;  1K8A F;  1K73 F;  3CCU D;  1Q86 F;  1VQ9 D;  1YJW D;  3CD6 D;  2OGK A;  3I55 D;  3CCS D;  1VQ6 D;  3CC7 D;  3PIO D;  4WFA D;  4IOC D;  1VQ5 D;  2NRQ A;  1QVG D;  4IOA D;  5GAH F;  5GAG F;  2WNY A;  3CCJ D;  5JVG D;  3C9G A;  5HL7 D;  3DLL D;  2NWU A;  1VQN D;  5DM6 D;  1KQS D;  1VQM D;  1M90 F;  3G71 D;  3OW2 D;  1W2B D;  3PIP D;  3J7Z F;  1YJ9 D;  3D7A A;  3CXC D;  1YIT D;  1KC8 F;  3CC2 D;  1VQK D;  3I56 D;  3CCV D;  1M1K F;  2ZJP D;  1N8R F;  4U67 D;  1VQ7 D;  4WF9 D;  1JJ2 D;  3CPW D;  3CF5 D;  1NJI F;  1Q7Y F;  1K9M F;  2PZZ A;  1YI2 D;  1Q81 F;  3CCL D;  4WFN D;  2OTL D;  2QA4 D;  1VQ8 D;  4WFB D;  1Q82 F;  5MLC G;  1MJI A;  5GAD F;  2ZJQ D;  3CCR D;  1KD1 F; 
#chains in the Genus database with same CATH homology
 5DM7 D;  4IO9 D;  1YIJ D;  1YHQ D;  3CC4 D;  1VQO D;  3CCQ D;  1VQP D;  2OTJ D;  5GAE F;  2QEX D;  1VQL D;  5JVH D;  3CMA D;  4UY8 F;  4WCE D;  3G4S D;  1QVF D;  1VQ4 D;  1IQ4 A;  3CCE D;  3CME D;  1S72 D;  5H1S H;  2ZJR D;  3CCM D;  3G6E D;  1YJN D;  1K8A F;  1K73 F;  3CCU D;  1Q86 F;  1VQ9 D;  1YJW D;  3CD6 D;  2OGK A;  3I55 D;  3CCS D;  1VQ6 D;  3CC7 D;  3PIO D;  4WFA D;  4IOC D;  1VQ5 D;  2NRQ A;  1QVG D;  4IOA D;  5GAH F;  5GAG F;  2WNY A;  3CCJ D;  5JVG D;  3C9G A;  5HL7 D;  3DLL D;  2NWU A;  1VQN D;  5DM6 D;  1KQS D;  1VQM D;  1M90 F;  3G71 D;  3OW2 D;  1W2B D;  3PIP D;  3J7Z F;  1YJ9 D;  3D7A A;  3CXC D;  1YIT D;  1KC8 F;  3CC2 D;  1VQK D;  3I56 D;  3CCV D;  1M1K F;  2ZJP D;  1N8R F;  4U67 D;  1VQ7 D;  4WF9 D;  1JJ2 D;  3CPW D;  3CF5 D;  1NJI F;  1Q7Y F;  1K9M F;  2PZZ A;  1YI2 D;  1Q81 F;  3CCL D;  4WFN D;  2OTL D;  2QA4 D;  1VQ8 D;  4WFB D;  1Q82 F;  5MLC G;  1MJI A;  5GAD F;  2ZJQ D;  3CCR D;  1KD1 F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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