1YI2D

Crystal structure of erythromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
165
structure length
140
Chain Sequence
FHEMREPRIEKVVVHMGIGHANAEDILGEITGQMPVRTKAKRTVGEFDIREGDPIGAKVTLRDEMAEEFLQTALPLAELATSQFDDTGNFSFGLDVTVNLVRPGYRVAKRDKASRSIPTKHRLNPADAVAFIESTYDVEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 22
structure length 140
sequence length 165
ec nomenclature
pdb deposition date 2005-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00281 Ribosomal_L5 Ribosomal protein L5
D PF00673 Ribosomal_L5_C ribosomal L5P family C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1440.10 Alpha Beta 2-Layer Sandwich 50s Ribosomal Protein L5; Chain: A, 50s Ribosomal Protein L5; Chain: A, 1yi2D00
3G4SD 3D7AA 2OGKA 5GAEF 3CC7D 1VQ6D 1NJIF 3DLLD 1S72D 4WFAD 3PIPD 1YIJD 3CMAD 1W2BD 4IOCD 3G6ED 5HL7D 1YI2D 1Q86F 3CCRD 1VQMD 5H1SH 3PIOD 1KC8F 1VQLD 3CCJD 3I56D 3CPWD 1VQ7D 3CC4D 3OW2D 2WNYA 1VQKD 1YITD 3CCSD 1VQ9D 1YJWD 1M1KF 3CCED 3CMED 1JJ2D 1VQOD 1K73F 1MJIA 3CCLD 2ZJRD 2QEXD 2PZZA 4WF9D 1K9MF 3CD6D 1QVFD 1VQPD 1K8AF 3G71D 5GAGF 1M90F 3CXCD 4UY8F 1VQND 4WCED 3J7ZF 3CCUD 3I55D 5DM6D 3CF5D 2ZJPD 2QA4D 1N8RF 1Q82F 1YJND 2NWUA 1VQ8D 2NRQA 4WFBD 1QVGD 1Q7YF 1Q81F 1VQ5D 5MLCG 3CCMD 3C9GA 5GADF 4WFND 3CCVD 2ZJQD 1KQSD 1IQ4A 4IO9D 1VQ4D 4IOAD 4U67D 2OTJD 1YHQD 5GAHF 3CC2D 1YJ9D 5JVGD 3CCQD 2OTLD 5DM7D 5JVHD 1KD1F
chains in the Genus database with same CATH superfamily
3G4SD 3D7AA 2OGKA 5GAEF 3CC7D 1VQ6D 1NJIF 3DLLD 1S72D 4WFAD 3PIPD 1YIJD 3CMAD 1W2BD 4IOCD 3G6ED 5HL7D 1YI2D 1Q86F 3CCRD 1VQMD 5H1SH 3PIOD 1KC8F 1VQLD 3CCJD 3I56D 3CPWD 1VQ7D 3CC4D 3OW2D 2WNYA 1VQKD 1YITD 3CCSD 1VQ9D 1YJWD 1M1KF 3CCED 3CMED 1JJ2D 1VQOD 1K73F 1MJIA 3CCLD 2ZJRD 2QEXD 2PZZA 4WF9D 1K9MF 3CD6D 1QVFD 1VQPD 1K8AF 3G71D 5GAGF 1M90F 3CXCD 4UY8F 1VQND 4WCED 3J7ZF 3CCUD 3I55D 5DM6D 3CF5D 2ZJPD 2QA4D 1N8RF 1Q82F 1YJND 2NWUA 1VQ8D 2NRQA 4WFBD 1QVGD 1Q7YF 1Q81F 1VQ5D 5MLCG 3CCMD 3C9GA 5GADF 4WFND 3CCVD 2ZJQD 1KQSD 1IQ4A 4IO9D 1VQ4D 4IOAD 4U67D 2OTJD 1YHQD 5GAHF 3CC2D 1YJ9D 5JVGD 3CCQD 2OTLD 5DM7D 5JVHD 1KD1F
chains in the Genus database with same CATH topology
3G4SD 3D7AA 2OGKA 5GAEF 3CC7D 1VQ6D 1NJIF 3DLLD 1S72D 4WFAD 3PIPD 1YIJD 3CMAD 1W2BD 4IOCD 3G6ED 5HL7D 1YI2D 1Q86F 3CCRD 1VQMD 5H1SH 3PIOD 1KC8F 1VQLD 3CCJD 3I56D 3CPWD 1VQ7D 3CC4D 3OW2D 2WNYA 1VQKD 1YITD 3CCSD 1VQ9D 1YJWD 1M1KF 3CCED 3CMED 1JJ2D 1VQOD 1K73F 1MJIA 3CCLD 2ZJRD 2QEXD 2PZZA 4WF9D 1K9MF 3CD6D 1QVFD 1VQPD 1K8AF 3G71D 5GAGF 1M90F 3CXCD 4UY8F 1VQND 4WCED 3J7ZF 3CCUD 3I55D 5DM6D 3CF5D 2ZJPD 2QA4D 1N8RF 1Q82F 1YJND 2NWUA 1VQ8D 2NRQA 4WFBD 1QVGD 1Q7YF 1Q81F 1VQ5D 5MLCG 3CCMD 3C9GA 5GADF 4WFND 3CCVD 2ZJQD 1KQSD 1IQ4A 4IO9D 1VQ4D 4IOAD 4U67D 2OTJD 1YHQD 5GAHF 3CC2D 1YJ9D 5JVGD 3CCQD 2OTLD 5DM7D 5JVHD 1KD1F
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3G4S D;  3D7A A;  2OGK A;  5GAE F;  3CC7 D;  1VQ6 D;  1NJI F;  3DLL D;  1S72 D;  4WFA D;  3PIP D;  1YIJ D;  3CMA D;  1W2B D;  4IOC D;  3G6E D;  5HL7 D;  1YI2 D;  1Q86 F;  3CCR D;  1VQM D;  5H1S H;  3PIO D;  1KC8 F;  1VQL D;  3CCJ D;  3I56 D;  3CPW D;  1VQ7 D;  3CC4 D;  3OW2 D;  2WNY A;  1VQK D;  1YIT D;  3CCS D;  1VQ9 D;  1YJW D;  1M1K F;  3CCE D;  3CME D;  1JJ2 D;  1VQO D;  1K73 F;  1MJI A;  3CCL D;  2ZJR D;  2QEX D;  2PZZ A;  4WF9 D;  1K9M F;  3CD6 D;  1QVF D;  1VQP D;  1K8A F;  3G71 D;  5GAG F;  1M90 F;  3CXC D;  4UY8 F;  1VQN D;  4WCE D;  3J7Z F;  3CCU D;  3I55 D;  5DM6 D;  3CF5 D;  2ZJP D;  2QA4 D;  1N8R F;  1Q82 F;  1YJN D;  2NWU A;  1VQ8 D;  2NRQ A;  4WFB D;  1QVG D;  1Q7Y F;  1Q81 F;  1VQ5 D;  5MLC G;  3CCM D;  3C9G A;  5GAD F;  4WFN D;  3CCV D;  2ZJQ D;  1KQS D;  1IQ4 A;  4IO9 D;  1VQ4 D;  4IOA D;  4U67 D;  2OTJ D;  1YHQ D;  5GAH F;  3CC2 D;  1YJ9 D;  5JVG D;  3CCQ D;  2OTL D;  5DM7 D;  5JVH D;  1KD1 F; 
#chains in the Genus database with same CATH topology
 3G4S D;  3D7A A;  2OGK A;  5GAE F;  3CC7 D;  1VQ6 D;  1NJI F;  3DLL D;  1S72 D;  4WFA D;  3PIP D;  1YIJ D;  3CMA D;  1W2B D;  4IOC D;  3G6E D;  5HL7 D;  1YI2 D;  1Q86 F;  3CCR D;  1VQM D;  5H1S H;  3PIO D;  1KC8 F;  1VQL D;  3CCJ D;  3I56 D;  3CPW D;  1VQ7 D;  3CC4 D;  3OW2 D;  2WNY A;  1VQK D;  1YIT D;  3CCS D;  1VQ9 D;  1YJW D;  1M1K F;  3CCE D;  3CME D;  1JJ2 D;  1VQO D;  1K73 F;  1MJI A;  3CCL D;  2ZJR D;  2QEX D;  2PZZ A;  4WF9 D;  1K9M F;  3CD6 D;  1QVF D;  1VQP D;  1K8A F;  3G71 D;  5GAG F;  1M90 F;  3CXC D;  4UY8 F;  1VQN D;  4WCE D;  3J7Z F;  3CCU D;  3I55 D;  5DM6 D;  3CF5 D;  2ZJP D;  2QA4 D;  1N8R F;  1Q82 F;  1YJN D;  2NWU A;  1VQ8 D;  2NRQ A;  4WFB D;  1QVG D;  1Q7Y F;  1Q81 F;  1VQ5 D;  5MLC G;  3CCM D;  3C9G A;  5GAD F;  4WFN D;  3CCV D;  2ZJQ D;  1KQS D;  1IQ4 A;  4IO9 D;  1VQ4 D;  4IOA D;  4U67 D;  2OTJ D;  1YHQ D;  5GAH F;  3CC2 D;  1YJ9 D;  5JVG D;  3CCQ D;  2OTL D;  5DM7 D;  5JVH D;  1KD1 F; 
#chains in the Genus database with same CATH homology
 3G4S D;  3D7A A;  2OGK A;  5GAE F;  3CC7 D;  1VQ6 D;  1NJI F;  3DLL D;  1S72 D;  4WFA D;  3PIP D;  1YIJ D;  3CMA D;  1W2B D;  4IOC D;  3G6E D;  5HL7 D;  1YI2 D;  1Q86 F;  3CCR D;  1VQM D;  5H1S H;  3PIO D;  1KC8 F;  1VQL D;  3CCJ D;  3I56 D;  3CPW D;  1VQ7 D;  3CC4 D;  3OW2 D;  2WNY A;  1VQK D;  1YIT D;  3CCS D;  1VQ9 D;  1YJW D;  1M1K F;  3CCE D;  3CME D;  1JJ2 D;  1VQO D;  1K73 F;  1MJI A;  3CCL D;  2ZJR D;  2QEX D;  2PZZ A;  4WF9 D;  1K9M F;  3CD6 D;  1QVF D;  1VQP D;  1K8A F;  3G71 D;  5GAG F;  1M90 F;  3CXC D;  4UY8 F;  1VQN D;  4WCE D;  3J7Z F;  3CCU D;  3I55 D;  5DM6 D;  3CF5 D;  2ZJP D;  2QA4 D;  1N8R F;  1Q82 F;  1YJN D;  2NWU A;  1VQ8 D;  2NRQ A;  4WFB D;  1QVG D;  1Q7Y F;  1Q81 F;  1VQ5 D;  5MLC G;  3CCM D;  3C9G A;  5GAD F;  4WFN D;  3CCV D;  2ZJQ D;  1KQS D;  1IQ4 A;  4IO9 D;  1VQ4 D;  4IOA D;  4U67 D;  2OTJ D;  1YHQ D;  5GAH F;  3CC2 D;  1YJ9 D;  5JVG D;  3CCQ D;  2OTL D;  5DM7 D;  5JVH D;  1KD1 F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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