3G4SD

Co-crystal structure of tiamulin bound to the large ribosomal subunit
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
165
structure length
140
Chain Sequence
FHEMREPRIEKVVVHMGIGHANAEDILGEITGQMPVRTKAKRTVGEFDIREGDPIGAKVTLRDEMAEEFLQTALPLAELATSQFDDTGNFSFGLDVTVNLVRPGYRVAKRDKASRSIPTKHRLNPADAVAFIESTYDVEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 13
structure length 140
sequence length 165
ec nomenclature
pdb deposition date 2009-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00281 Ribosomal_L5 Ribosomal protein L5
D PF00673 Ribosomal_L5_C ribosomal L5P family C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1440.10 Alpha Beta 2-Layer Sandwich 50s Ribosomal Protein L5; Chain: A, 50s Ribosomal Protein L5; Chain: A, 3g4sD00
1YJ9D 1IQ4A 5HL7D 2WNYA 1YI2D 3C9GA 2QEXD 5GAEF 3CXCD 3CPWD 1Q82F 5GADF 3CCSD 3CCJD 1KC8F 3CC2D 1K9MF 4WCED 1VQ8D 1YIJD 5DM6D 1VQLD 5GAGF 3CMED 1KD1F 3CCUD 3D7AA 3I55D 1VQOD 2OTLD 3CCLD 1M90F 3I56D 1VQ9D 2QA4D 1VQ5D 1JJ2D 1W2BD 1VQ4D 1Q86F 1Q81F 1YITD 3CC7D 3G4SD 1Q7YF 4IO9D 1VQND 1VQ7D 4WFAD 2ZJPD 2ZJQD 5DM7D 1S72D 1KQSD 1YJND 4UY8F 4WF9D 1N8RF 4IOCD 3J7ZF 3CCED 3CF5D 3CD6D 5MLCG 3OW2D 2OGKA 1VQ6D 5GAHF 4U67D 3CCVD 1QVFD 3G71D 1K73F 4IOAD 3CCQD 1VQMD 3CMAD 3DLLD 2OTJD 3PIOD 1NJIF 4WFBD 3CCMD 3CCRD 2NRQA 1VQKD 5H1SH 1YJWD 3CC4D 5JVGD 2NWUA 3PIPD 1VQPD 1YHQD 1QVGD 3G6ED 1K8AF 1M1KF 5JVHD 1MJIA 2ZJRD 2PZZA 4WFND
chains in the Genus database with same CATH superfamily
1YJ9D 1IQ4A 5HL7D 2WNYA 1YI2D 3C9GA 2QEXD 5GAEF 3CXCD 3CPWD 1Q82F 5GADF 3CCSD 3CCJD 1KC8F 3CC2D 1K9MF 4WCED 1VQ8D 1YIJD 5DM6D 1VQLD 5GAGF 3CMED 1KD1F 3CCUD 3D7AA 3I55D 1VQOD 2OTLD 3CCLD 1M90F 3I56D 1VQ9D 2QA4D 1VQ5D 1JJ2D 1W2BD 1VQ4D 1Q86F 1Q81F 1YITD 3CC7D 3G4SD 1Q7YF 4IO9D 1VQND 1VQ7D 4WFAD 2ZJPD 2ZJQD 5DM7D 1S72D 1KQSD 1YJND 4UY8F 4WF9D 1N8RF 4IOCD 3J7ZF 3CCED 3CF5D 3CD6D 5MLCG 3OW2D 2OGKA 1VQ6D 5GAHF 4U67D 3CCVD 1QVFD 3G71D 1K73F 4IOAD 3CCQD 1VQMD 3CMAD 3DLLD 2OTJD 3PIOD 1NJIF 4WFBD 3CCMD 3CCRD 2NRQA 1VQKD 5H1SH 1YJWD 3CC4D 5JVGD 2NWUA 3PIPD 1VQPD 1YHQD 1QVGD 3G6ED 1K8AF 1M1KF 5JVHD 1MJIA 2ZJRD 2PZZA 4WFND
chains in the Genus database with same CATH topology
1YJ9D 1IQ4A 5HL7D 2WNYA 1YI2D 3C9GA 2QEXD 5GAEF 3CXCD 3CPWD 1Q82F 5GADF 3CCSD 3CCJD 1KC8F 3CC2D 1K9MF 4WCED 1VQ8D 1YIJD 5DM6D 1VQLD 5GAGF 3CMED 1KD1F 3CCUD 3D7AA 3I55D 1VQOD 2OTLD 3CCLD 1M90F 3I56D 1VQ9D 2QA4D 1VQ5D 1JJ2D 1W2BD 1VQ4D 1Q86F 1Q81F 1YITD 3CC7D 3G4SD 1Q7YF 4IO9D 1VQND 1VQ7D 4WFAD 2ZJPD 2ZJQD 5DM7D 1S72D 1KQSD 1YJND 4UY8F 4WF9D 1N8RF 4IOCD 3J7ZF 3CCED 3CF5D 3CD6D 5MLCG 3OW2D 2OGKA 1VQ6D 5GAHF 4U67D 3CCVD 1QVFD 3G71D 1K73F 4IOAD 3CCQD 1VQMD 3CMAD 3DLLD 2OTJD 3PIOD 1NJIF 4WFBD 3CCMD 3CCRD 2NRQA 1VQKD 5H1SH 1YJWD 3CC4D 5JVGD 2NWUA 3PIPD 1VQPD 1YHQD 1QVGD 3G6ED 1K8AF 1M1KF 5JVHD 1MJIA 2ZJRD 2PZZA 4WFND
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YJ9 D;  1IQ4 A;  5HL7 D;  2WNY A;  1YI2 D;  3C9G A;  2QEX D;  5GAE F;  3CXC D;  3CPW D;  1Q82 F;  5GAD F;  3CCS D;  3CCJ D;  1KC8 F;  3CC2 D;  1K9M F;  4WCE D;  1VQ8 D;  1YIJ D;  5DM6 D;  1VQL D;  5GAG F;  3CME D;  1KD1 F;  3CCU D;  3D7A A;  3I55 D;  1VQO D;  2OTL D;  3CCL D;  1M90 F;  3I56 D;  1VQ9 D;  2QA4 D;  1VQ5 D;  1JJ2 D;  1W2B D;  1VQ4 D;  1Q86 F;  1Q81 F;  1YIT D;  3CC7 D;  3G4S D;  1Q7Y F;  4IO9 D;  1VQN D;  1VQ7 D;  4WFA D;  2ZJP D;  2ZJQ D;  5DM7 D;  1S72 D;  1KQS D;  1YJN D;  4UY8 F;  4WF9 D;  1N8R F;  4IOC D;  3J7Z F;  3CCE D;  3CF5 D;  3CD6 D;  5MLC G;  3OW2 D;  2OGK A;  1VQ6 D;  5GAH F;  4U67 D;  3CCV D;  1QVF D;  3G71 D;  1K73 F;  4IOA D;  3CCQ D;  1VQM D;  3CMA D;  3DLL D;  2OTJ D;  3PIO D;  1NJI F;  4WFB D;  3CCM D;  3CCR D;  2NRQ A;  1VQK D;  5H1S H;  1YJW D;  3CC4 D;  5JVG D;  2NWU A;  3PIP D;  1VQP D;  1YHQ D;  1QVG D;  3G6E D;  1K8A F;  1M1K F;  5JVH D;  1MJI A;  2ZJR D;  2PZZ A;  4WFN D; 
#chains in the Genus database with same CATH topology
 1YJ9 D;  1IQ4 A;  5HL7 D;  2WNY A;  1YI2 D;  3C9G A;  2QEX D;  5GAE F;  3CXC D;  3CPW D;  1Q82 F;  5GAD F;  3CCS D;  3CCJ D;  1KC8 F;  3CC2 D;  1K9M F;  4WCE D;  1VQ8 D;  1YIJ D;  5DM6 D;  1VQL D;  5GAG F;  3CME D;  1KD1 F;  3CCU D;  3D7A A;  3I55 D;  1VQO D;  2OTL D;  3CCL D;  1M90 F;  3I56 D;  1VQ9 D;  2QA4 D;  1VQ5 D;  1JJ2 D;  1W2B D;  1VQ4 D;  1Q86 F;  1Q81 F;  1YIT D;  3CC7 D;  3G4S D;  1Q7Y F;  4IO9 D;  1VQN D;  1VQ7 D;  4WFA D;  2ZJP D;  2ZJQ D;  5DM7 D;  1S72 D;  1KQS D;  1YJN D;  4UY8 F;  4WF9 D;  1N8R F;  4IOC D;  3J7Z F;  3CCE D;  3CF5 D;  3CD6 D;  5MLC G;  3OW2 D;  2OGK A;  1VQ6 D;  5GAH F;  4U67 D;  3CCV D;  1QVF D;  3G71 D;  1K73 F;  4IOA D;  3CCQ D;  1VQM D;  3CMA D;  3DLL D;  2OTJ D;  3PIO D;  1NJI F;  4WFB D;  3CCM D;  3CCR D;  2NRQ A;  1VQK D;  5H1S H;  1YJW D;  3CC4 D;  5JVG D;  2NWU A;  3PIP D;  1VQP D;  1YHQ D;  1QVG D;  3G6E D;  1K8A F;  1M1K F;  5JVH D;  1MJI A;  2ZJR D;  2PZZ A;  4WFN D; 
#chains in the Genus database with same CATH homology
 1YJ9 D;  1IQ4 A;  5HL7 D;  2WNY A;  1YI2 D;  3C9G A;  2QEX D;  5GAE F;  3CXC D;  3CPW D;  1Q82 F;  5GAD F;  3CCS D;  3CCJ D;  1KC8 F;  3CC2 D;  1K9M F;  4WCE D;  1VQ8 D;  1YIJ D;  5DM6 D;  1VQL D;  5GAG F;  3CME D;  1KD1 F;  3CCU D;  3D7A A;  3I55 D;  1VQO D;  2OTL D;  3CCL D;  1M90 F;  3I56 D;  1VQ9 D;  2QA4 D;  1VQ5 D;  1JJ2 D;  1W2B D;  1VQ4 D;  1Q86 F;  1Q81 F;  1YIT D;  3CC7 D;  3G4S D;  1Q7Y F;  4IO9 D;  1VQN D;  1VQ7 D;  4WFA D;  2ZJP D;  2ZJQ D;  5DM7 D;  1S72 D;  1KQS D;  1YJN D;  4UY8 F;  4WF9 D;  1N8R F;  4IOC D;  3J7Z F;  3CCE D;  3CF5 D;  3CD6 D;  5MLC G;  3OW2 D;  2OGK A;  1VQ6 D;  5GAH F;  4U67 D;  3CCV D;  1QVF D;  3G71 D;  1K73 F;  4IOA D;  3CCQ D;  1VQM D;  3CMA D;  3DLL D;  2OTJ D;  3PIO D;  1NJI F;  4WFB D;  3CCM D;  3CCR D;  2NRQ A;  1VQK D;  5H1S H;  1YJW D;  3CC4 D;  5JVG D;  2NWU A;  3PIP D;  1VQP D;  1YHQ D;  1QVG D;  3G6E D;  1K8A F;  1M1K F;  5JVH D;  1MJI A;  2ZJR D;  2PZZ A;  4WFN D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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