3G6ED

Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
165
structure length
140
Chain Sequence
FHEMREPRIEKVVVHMGIGHANAEDILGEITGQMPVRTKAKRTVGEFDIREGDPIGAKVTLRDEMAEEFLQTALPLAELATSQFDDTGNFSFGLDVTVNLVRPGYRVAKRDKASRSIPTKHRLNPADAVAFIESTYDVEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 15
structure length 140
sequence length 165
ec nomenclature
pdb deposition date 2009-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00281 Ribosomal_L5 Ribosomal protein L5
D PF00673 Ribosomal_L5_C ribosomal L5P family C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1440.10 Alpha Beta 2-Layer Sandwich 50s Ribosomal Protein L5; Chain: A, 50s Ribosomal Protein L5; Chain: A, 3g6eD00
1N8RF 1MJIA 3CCJD 5HL7D 1W2BD 3CCED 3G4SD 5GAGF 2ZJRD 1VQ4D 4WF9D 1VQKD 3CD6D 1YJND 3PIOD 1Q86F 3PIPD 2OTLD 3CF5D 5GAEF 1VQ5D 5GADF 1K73F 3CC7D 4WFAD 4UY8F 1K8AF 4IO9D 2PZZA 2QEXD 1JJ2D 4WCED 5DM6D 3CXCD 3CC4D 1VQPD 1YJ9D 3I56D 3OW2D 1VQLD 4WFBD 2ZJPD 1VQMD 2OTJD 2QA4D 1VQ7D 3CCMD 3CCRD 3CPWD 1Q7YF 1KC8F 1K9MF 1YJWD 3CCVD 2NWUA 3J7ZF 3DLLD 4U67D 1KQSD 3G71D 5JVGD 3G6ED 1S72D 3CCSD 1IQ4A 3I55D 2OGKA 1QVGD 4IOCD 3CCUD 3C9GA 5H1SH 3CC2D 1YITD 4WFND 3CCQD 2ZJQD 1VQ9D 2WNYA 1VQ6D 5GAHF 1VQOD 5DM7D 1YHQD 1QVFD 1KD1F 4IOAD 1VQND 1YI2D 1Q81F 3D7AA 1Q82F 2NRQA 1YIJD 5MLCG 3CCLD 3CMED 1NJIF 1VQ8D 5JVHD 3CMAD 1M1KF 1M90F
chains in the Genus database with same CATH superfamily
1N8RF 1MJIA 3CCJD 5HL7D 1W2BD 3CCED 3G4SD 5GAGF 2ZJRD 1VQ4D 4WF9D 1VQKD 3CD6D 1YJND 3PIOD 1Q86F 3PIPD 2OTLD 3CF5D 5GAEF 1VQ5D 5GADF 1K73F 3CC7D 4WFAD 4UY8F 1K8AF 4IO9D 2PZZA 2QEXD 1JJ2D 4WCED 5DM6D 3CXCD 3CC4D 1VQPD 1YJ9D 3I56D 3OW2D 1VQLD 4WFBD 2ZJPD 1VQMD 2OTJD 2QA4D 1VQ7D 3CCMD 3CCRD 3CPWD 1Q7YF 1KC8F 1K9MF 1YJWD 3CCVD 2NWUA 3J7ZF 3DLLD 4U67D 1KQSD 3G71D 5JVGD 3G6ED 1S72D 3CCSD 1IQ4A 3I55D 2OGKA 1QVGD 4IOCD 3CCUD 3C9GA 5H1SH 3CC2D 1YITD 4WFND 3CCQD 2ZJQD 1VQ9D 2WNYA 1VQ6D 5GAHF 1VQOD 5DM7D 1YHQD 1QVFD 1KD1F 4IOAD 1VQND 1YI2D 1Q81F 3D7AA 1Q82F 2NRQA 1YIJD 5MLCG 3CCLD 3CMED 1NJIF 1VQ8D 5JVHD 3CMAD 1M1KF 1M90F
chains in the Genus database with same CATH topology
1N8RF 1MJIA 3CCJD 5HL7D 1W2BD 3CCED 3G4SD 5GAGF 2ZJRD 1VQ4D 4WF9D 1VQKD 3CD6D 1YJND 3PIOD 1Q86F 3PIPD 2OTLD 3CF5D 5GAEF 1VQ5D 5GADF 1K73F 3CC7D 4WFAD 4UY8F 1K8AF 4IO9D 2PZZA 2QEXD 1JJ2D 4WCED 5DM6D 3CXCD 3CC4D 1VQPD 1YJ9D 3I56D 3OW2D 1VQLD 4WFBD 2ZJPD 1VQMD 2OTJD 2QA4D 1VQ7D 3CCMD 3CCRD 3CPWD 1Q7YF 1KC8F 1K9MF 1YJWD 3CCVD 2NWUA 3J7ZF 3DLLD 4U67D 1KQSD 3G71D 5JVGD 3G6ED 1S72D 3CCSD 1IQ4A 3I55D 2OGKA 1QVGD 4IOCD 3CCUD 3C9GA 5H1SH 3CC2D 1YITD 4WFND 3CCQD 2ZJQD 1VQ9D 2WNYA 1VQ6D 5GAHF 1VQOD 5DM7D 1YHQD 1QVFD 1KD1F 4IOAD 1VQND 1YI2D 1Q81F 3D7AA 1Q82F 2NRQA 1YIJD 5MLCG 3CCLD 3CMED 1NJIF 1VQ8D 5JVHD 3CMAD 1M1KF 1M90F
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N8R F;  1MJI A;  3CCJ D;  5HL7 D;  1W2B D;  3CCE D;  3G4S D;  5GAG F;  2ZJR D;  1VQ4 D;  4WF9 D;  1VQK D;  3CD6 D;  1YJN D;  3PIO D;  1Q86 F;  3PIP D;  2OTL D;  3CF5 D;  5GAE F;  1VQ5 D;  5GAD F;  1K73 F;  3CC7 D;  4WFA D;  4UY8 F;  1K8A F;  4IO9 D;  2PZZ A;  2QEX D;  1JJ2 D;  4WCE D;  5DM6 D;  3CXC D;  3CC4 D;  1VQP D;  1YJ9 D;  3I56 D;  3OW2 D;  1VQL D;  4WFB D;  2ZJP D;  1VQM D;  2OTJ D;  2QA4 D;  1VQ7 D;  3CCM D;  3CCR D;  3CPW D;  1Q7Y F;  1KC8 F;  1K9M F;  1YJW D;  3CCV D;  2NWU A;  3J7Z F;  3DLL D;  4U67 D;  1KQS D;  3G71 D;  5JVG D;  3G6E D;  1S72 D;  3CCS D;  1IQ4 A;  3I55 D;  2OGK A;  1QVG D;  4IOC D;  3CCU D;  3C9G A;  5H1S H;  3CC2 D;  1YIT D;  4WFN D;  3CCQ D;  2ZJQ D;  1VQ9 D;  2WNY A;  1VQ6 D;  5GAH F;  1VQO D;  5DM7 D;  1YHQ D;  1QVF D;  1KD1 F;  4IOA D;  1VQN D;  1YI2 D;  1Q81 F;  3D7A A;  1Q82 F;  2NRQ A;  1YIJ D;  5MLC G;  3CCL D;  3CME D;  1NJI F;  1VQ8 D;  5JVH D;  3CMA D;  1M1K F;  1M90 F; 
#chains in the Genus database with same CATH topology
 1N8R F;  1MJI A;  3CCJ D;  5HL7 D;  1W2B D;  3CCE D;  3G4S D;  5GAG F;  2ZJR D;  1VQ4 D;  4WF9 D;  1VQK D;  3CD6 D;  1YJN D;  3PIO D;  1Q86 F;  3PIP D;  2OTL D;  3CF5 D;  5GAE F;  1VQ5 D;  5GAD F;  1K73 F;  3CC7 D;  4WFA D;  4UY8 F;  1K8A F;  4IO9 D;  2PZZ A;  2QEX D;  1JJ2 D;  4WCE D;  5DM6 D;  3CXC D;  3CC4 D;  1VQP D;  1YJ9 D;  3I56 D;  3OW2 D;  1VQL D;  4WFB D;  2ZJP D;  1VQM D;  2OTJ D;  2QA4 D;  1VQ7 D;  3CCM D;  3CCR D;  3CPW D;  1Q7Y F;  1KC8 F;  1K9M F;  1YJW D;  3CCV D;  2NWU A;  3J7Z F;  3DLL D;  4U67 D;  1KQS D;  3G71 D;  5JVG D;  3G6E D;  1S72 D;  3CCS D;  1IQ4 A;  3I55 D;  2OGK A;  1QVG D;  4IOC D;  3CCU D;  3C9G A;  5H1S H;  3CC2 D;  1YIT D;  4WFN D;  3CCQ D;  2ZJQ D;  1VQ9 D;  2WNY A;  1VQ6 D;  5GAH F;  1VQO D;  5DM7 D;  1YHQ D;  1QVF D;  1KD1 F;  4IOA D;  1VQN D;  1YI2 D;  1Q81 F;  3D7A A;  1Q82 F;  2NRQ A;  1YIJ D;  5MLC G;  3CCL D;  3CME D;  1NJI F;  1VQ8 D;  5JVH D;  3CMA D;  1M1K F;  1M90 F; 
#chains in the Genus database with same CATH homology
 1N8R F;  1MJI A;  3CCJ D;  5HL7 D;  1W2B D;  3CCE D;  3G4S D;  5GAG F;  2ZJR D;  1VQ4 D;  4WF9 D;  1VQK D;  3CD6 D;  1YJN D;  3PIO D;  1Q86 F;  3PIP D;  2OTL D;  3CF5 D;  5GAE F;  1VQ5 D;  5GAD F;  1K73 F;  3CC7 D;  4WFA D;  4UY8 F;  1K8A F;  4IO9 D;  2PZZ A;  2QEX D;  1JJ2 D;  4WCE D;  5DM6 D;  3CXC D;  3CC4 D;  1VQP D;  1YJ9 D;  3I56 D;  3OW2 D;  1VQL D;  4WFB D;  2ZJP D;  1VQM D;  2OTJ D;  2QA4 D;  1VQ7 D;  3CCM D;  3CCR D;  3CPW D;  1Q7Y F;  1KC8 F;  1K9M F;  1YJW D;  3CCV D;  2NWU A;  3J7Z F;  3DLL D;  4U67 D;  1KQS D;  3G71 D;  5JVG D;  3G6E D;  1S72 D;  3CCS D;  1IQ4 A;  3I55 D;  2OGK A;  1QVG D;  4IOC D;  3CCU D;  3C9G A;  5H1S H;  3CC2 D;  1YIT D;  4WFN D;  3CCQ D;  2ZJQ D;  1VQ9 D;  2WNY A;  1VQ6 D;  5GAH F;  1VQO D;  5DM7 D;  1YHQ D;  1QVF D;  1KD1 F;  4IOA D;  1VQN D;  1YI2 D;  1Q81 F;  3D7A A;  1Q82 F;  2NRQ A;  1YIJ D;  5MLC G;  3CCL D;  3CME D;  1NJI F;  1VQ8 D;  5JVH D;  3CMA D;  1M1K F;  1M90 F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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