4BPWA

Crystal structure of human primase bound to utp
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
407
structure length
382
Chain Sequence
FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKGEL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
molecule keywords DNA PRIMASE SMALL SUBUNIT
molecule tags Transferase
source organism Homo sapiens
total genus 120
structure length 382
sequence length 407
chains with identical sequence C
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 4bpwA00
1ZT2A 4RR2A 4LIKA 4MHQA 2FARA 2FAOA 4BPXA 5EXRA 2FAQA 4BPUA 4LILA 4BPWA 4MM2A 4LIMA
chains in the Genus database with same CATH superfamily
2FAQA 1ZT2A 4RR2A 4LIKA 4MHQA 2ATZA 1V34A 2FAOA 4BPXA 1V33A 5EXRA 2FARA 4BPUA 1G71A 4LILA 4BPWA 4MM2A 4LIMA
chains in the Genus database with same CATH topology
2FAQA 1ZT2A 4RR2A 4LIKA 4MHQA 1V34A 2FAOA 4BPXA 1V33A 5EXRA 2FARA 4BPUA 1G71A 4LILA 4BPWA 4MM2A 4LIMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZT2 A;  4RR2 A;  4LIK A;  4MHQ A;  2FAR A;  2FAO A;  4BPX A;  5EXR A;  2FAQ A;  4BPU A;  4LIL A;  4BPW A;  4MM2 A;  4LIM A; 
#chains in the Genus database with same CATH topology
 2FAQ A;  1ZT2 A;  4RR2 A;  4LIK A;  4MHQ A;  2ATZ A;  1V34 A;  2FAO A;  4BPX A;  1V33 A;  5EXR A;  2FAR A;  4BPU A;  1G71 A;  4LIL A;  4BPW A;  4MM2 A;  4LIM A; 
#chains in the Genus database with same CATH homology
 2FAQ A;  1ZT2 A;  4RR2 A;  4LIK A;  4MHQ A;  1V34 A;  2FAO A;  4BPX A;  1V33 A;  5EXR A;  2FAR A;  4BPU A;  1G71 A;  4LIL A;  4BPW A;  4MM2 A;  4LIM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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