4BPXA

Crystal structure of human primase in complex with the primase- binding motif of dna polymerase alpha
Total Genus 121
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
406
structure length
381
Chain Sequence
TFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA PRIMASE SMALL SUBUNIT
total genus 121
structure length 381
sequence length 406
chains with identical sequence C
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 4bpxA00
4MM2A 2FARA 4RR2A 2FAOA 4LILA 1ZT2A 4BPUA 4MHQA 4LIMA 5EXRA 4BPXA 4BPWA 4LIKA 2FAQA
chains in the Genus database with same CATH superfamily
4MM2A 2FARA 4RR2A 2FAOA 1V34A 4LILA 1ZT2A 1V33A 2ATZA 1G71A 4MHQA 4LIMA 5EXRA 4BPUA 4BPXA 4BPWA 4LIKA 2FAQA
chains in the Genus database with same CATH topology
4MM2A 2FARA 4RR2A 2FAOA 1V34A 4LILA 1ZT2A 1V33A 1G71A 4MHQA 4LIMA 5EXRA 4BPUA 4BPXA 4BPWA 4LIKA 2FAQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MM2 A;  2FAR A;  4RR2 A;  2FAO A;  4LIL A;  1ZT2 A;  4BPU A;  4MHQ A;  4LIM A;  5EXR A;  4BPX A;  4BPW A;  4LIK A;  2FAQ A; 
#chains in the Genus database with same CATH topology
 4MM2 A;  2FAR A;  4RR2 A;  2FAO A;  1V34 A;  4LIL A;  1ZT2 A;  1V33 A;  2ATZ A;  1G71 A;  4MHQ A;  4LIM A;  5EXR A;  4BPU A;  4BPX A;  4BPW A;  4LIK A;  2FAQ A; 
#chains in the Genus database with same CATH homology
 4MM2 A;  2FAR A;  4RR2 A;  2FAO A;  1V34 A;  4LIL A;  1ZT2 A;  1V33 A;  1G71 A;  4MHQ A;  4LIM A;  5EXR A;  4BPU A;  4BPX A;  4BPW A;  4LIK A;  2FAQ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...