4RR2A

Crystal structure of human primase
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
415
structure length
389
Chain Sequence
METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLKKSD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the human primase.
pubmed doi rcsb
molecule keywords DNA primase small subunit
molecule tags Transferase
source organism Homo sapiens
total genus 131
structure length 389
sequence length 415
chains with identical sequence C
ec nomenclature ec 2.7.7.-:
pdb deposition date 2014-11-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 4rr2A00
4LIKA 2FAOA 4BPWA 4BPUA 4LILA 4MHQA 4LIMA 1ZT2A 4BPXA 5EXRA 4RR2A 2FARA 2FAQA 4MM2A
chains in the Genus database with same CATH superfamily
2ATZA 1V34A 4LIKA 2FAOA 4BPWA 4BPUA 1V33A 1G71A 4LILA 4LIMA 4MHQA 1ZT2A 4BPXA 5EXRA 4RR2A 2FARA 2FAQA 4MM2A
chains in the Genus database with same CATH topology
1V34A 4LIKA 2FAOA 4BPWA 4BPUA 1V33A 1G71A 4LILA 4LIMA 4MHQA 1ZT2A 4BPXA 5EXRA 4RR2A 2FARA 2FAQA 4MM2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LIK A;  2FAO A;  4BPW A;  4BPU A;  4LIL A;  4MHQ A;  4LIM A;  1ZT2 A;  4BPX A;  5EXR A;  4RR2 A;  2FAR A;  2FAQ A;  4MM2 A; 
#chains in the Genus database with same CATH topology
 2ATZ A;  1V34 A;  4LIK A;  2FAO A;  4BPW A;  4BPU A;  1V33 A;  1G71 A;  4LIL A;  4LIM A;  4MHQ A;  1ZT2 A;  4BPX A;  5EXR A;  4RR2 A;  2FAR A;  2FAQ A;  4MM2 A; 
#chains in the Genus database with same CATH homology
 1V34 A;  4LIK A;  2FAO A;  4BPW A;  4BPU A;  1V33 A;  1G71 A;  4LIL A;  4LIM A;  4MHQ A;  1ZT2 A;  4BPX A;  5EXR A;  4RR2 A;  2FAR A;  2FAQ A;  4MM2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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