4BPUA

Crystal structure of human primase in heterodimeric form, comprising pris and truncated pril lacking the c-terminal fe-s domain.
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
405
structure length
380
Chain Sequence
FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA PRIMASE SMALL SUBUNIT
total genus 125
structure length 380
sequence length 405
chains with identical sequence C
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 4bpuA00
4BPXA 4LIMA 1ZT2A 4MHQA 4MM2A 2FARA 4LILA 2FAOA 4LIKA 4RR2A 4BPUA 5EXRA 2FAQA 4BPWA
chains in the Genus database with same CATH superfamily
4BPXA 4LIMA 1ZT2A 4MHQA 4MM2A 1V33A 2FARA 4LILA 2FAOA 1G71A 1V34A 4LIKA 4RR2A 4BPUA 2ATZA 5EXRA 2FAQA 4BPWA
chains in the Genus database with same CATH topology
4BPXA 4LIMA 1ZT2A 4MHQA 4MM2A 1V33A 2FARA 4LILA 2FAOA 1G71A 1V34A 4LIKA 4RR2A 4BPUA 5EXRA 2FAQA 4BPWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BPX A;  4LIM A;  1ZT2 A;  4MHQ A;  4MM2 A;  2FAR A;  4LIL A;  2FAO A;  4LIK A;  4RR2 A;  4BPU A;  5EXR A;  2FAQ A;  4BPW A; 
#chains in the Genus database with same CATH topology
 4BPX A;  4LIM A;  1ZT2 A;  4MHQ A;  4MM2 A;  1V33 A;  2FAR A;  4LIL A;  2FAO A;  1G71 A;  1V34 A;  4LIK A;  4RR2 A;  4BPU A;  2ATZ A;  5EXR A;  2FAQ A;  4BPW A; 
#chains in the Genus database with same CATH homology
 4BPX A;  4LIM A;  1ZT2 A;  4MHQ A;  4MM2 A;  1V33 A;  2FAR A;  4LIL A;  2FAO A;  1G71 A;  1V34 A;  4LIK A;  4RR2 A;  4BPU A;  5EXR A;  2FAQ A;  4BPW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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